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ADAMTS4
| Symbol: | ADAMTS4 | | Name(s): | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ADAMTS-2, ADAMTS-4, ADMP-1, KIAA0688 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17606262 |
ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of atherosclerotic plaques. |
| 18039650 |
after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9. |
| 18042673 |
Crystal structures of the two most active human aggrecanase isoforms, ADAMTS4 and ADAMTS5, each in complex with bound inhiitor. |
| 18050214 |
PKCzeta is involved in regulation of IL-1beta-induced NF-kappaB signaling in human osteoarthritis chondrocytes, which regulates downstream expression of ADAMTS-4 and NOS2 via NF-kappaB. |
| 17978660 |
In both nucleus pulposis and anulus fibrosus, ADAMTS4 was higher in discs with a higher level of degeneration. Aggrecan fragmentation profile analysis showed the involvement of aggrecanases and other proteases during disc degeneration. |
| 17470431 |
TIMP-3 inhibition of ADAMTS-4 is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4 |
| 11854269 |
has a specific cleavage site at the matrix metalloproteinase site in its interglobular domain |
| 17430884 |
ADAMTS-5 is a major aggrecanase in cartilage metabolism and pathology, with aggrecanase activity at least 1,000-fold greater than that of ADAMTS-4 under physiological conditions |
| 17265492 |
Our data suggest that both ADAMTS-4 and ADAMTS-5 contribute to the structural damage that characterizes human osteoarthritis. |
| 12202483 |
Autocatalytic cleavage reveals multiple glycosaminoglycan-binding sites | →View more information from publications. |
Recent Publications on ADAMTS4: |  |
Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes.
Here, we tested the matrilin-3-dependent induction of... | 21st October, 2009
| Institute for Clinical Chemistry, University of Cologne, Germany.
| FEBS Lett. 2009 Oct 17.
DOI Direct Link |
Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
We studied changes in chondrocyte gene expression, aggrecan degradation,... | 30th September, 2009
| Department of Biological Engineering, Massachusetts Institute of
| Arch Biochem Biophys. 2009 Sep;489(1-2):118-26. Epub 2009 Jul 14.
DOI Direct Link |
Proteolytic processing causes extensive heterogeneity of tissue matrilin forms.
The matrilins are a family of multidomain extracellular matrix proteins... | 29th September, 2009
| Center for Biochemistry, Medical Faculty, University of Cologne, Cologne,
| J Biol Chem. 2009 Aug 7;284(32):21545-56. Epub 2009 Jun 16.
DOI Direct Link |
Cell death-associated ADAMTS4 and versican degradation in vascular tissue.
High blood flow through baboon polytetrafluorethylene aorto-iliac grafts... | 16th September, 2009
| Center for Cardiovascular Biology, PO Box 358050, University of Washington
| J Histochem Cytochem. 2009 Sep;57(9):889-97. Epub 2009 Jun 8.
DOI Direct Link |
Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer.
BACKGROUND: Although contribution of matrix metalloproteinases in cancer... | 6th August, 2009
| Department of Molecular Biology and Biochemistry, Graduate School of
| Head Neck. 2009 Jun;31(6):793-801.
DOI Direct Link |
→View more research publications. |
ADAMTS4 results (if any) from reagent suppliers | 
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ADAMTS4 antibody - Propeptide domain (ab45038) | Abcam
Rabbit polyclonal to ADAMTS4 - Propeptide domain. A disintegrin like and metalloproteinase thrombospondin type 1 motif 4 (ADAMTS4 or aggrecanase 1) is a
...
http://www.abcam.com/adamts4-antibody-propeptide-domain-ab45...
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ADAMTS4 antibody, ADAMTS-4 Antibody, Rabbit Polyclonal Antibody
Buy quality rabbit ADAMTS4 antibody (interacts with human), anti-ADAMTS4, ADAMTS -4 antibody, rabbit polyclonal antibody, ADAMTS-4 Antibody, ...
http://www.genwaybio.com/product_info.php?products_id=10824...
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Peptide-affinity Purified Polyclonal Antibody to ADAMTS4 ...
ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular ...
http://www.imgenex.com/tds/IMG-71924.pdf...
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ADAMTS4 antibodies: Signal Transduction > Cytoskeleton / ECM ...
ADAMTS4 antibodies. ... ADAMTS4 antibody - Amino end of propeptide domain. WB. Rabbit polyclonal ... ADAMTS4 antibody - Propeptide domain ...
http://www.abcam.com/index.html?t=69711&pt=1&c=778&ei=&mu=ra...
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Anti-ADAMTS-4, C-terminal (A4976) - Data Sheet
role for ADAMTS-4 in aggrecan cleavage and cartilage destruction, especially in arthritis.2 ... retinoic acid suggests the possibility that ADAMTS-4 ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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ADAMTS Antibody / ADAMTS Antibodies
ADAMTS-4 (K-20) Antibody, sc-16533, goat IgG, internal (h), WB, IF, ELISA, m, r, h, cow ... ADAMTS-4 (Y-20) Antibody, sc-16534, goat IgG, C-terminus (h) ...
http://www.scbt.com/table-adamts.html...
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Antibodies to Extracellular Matrix Proteins
A4726, Anti-ADAMTS-4, Propeptide Region antibody produced in rabbit, (polyclonal ), affinity isolated antibody, human ... ADAMTS4(9507) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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