Sunday November 22 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

BAG4


Suggest Content
Advertise Here
Gene DB Home
Symbol:BAG4
Name(s):BCL2-associated athanogene 4
Type:protein-coding
Organism:Homo sapiens
Synonyms:BAG-4, SODD
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
14559896 BAG-4 functions as a negative regulator for apobec-1-mediated apoB mRNA editing
12706861 SODD/BAG-4 is not only a silencer of TNFR1 but also a modulator of CD95 activity, regulating the balance of both death-promoting and -depressing signals
17366557 results of analysis of the genome-wide scan data was a 20 cM region at 8p11-23 in which markers had LODs > or =1.0. Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 and BAG4.
17178857 Gene induces transformed phenotype when overexpressed in a cancer breast cell line.
12017295 Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells.
12875962 These data confirm that silencer of death domains (SODD) and death receptor 3 (DR3) are expressed in a regulated manner during renal transplant rejection, and identify DR3 as a potential inducible mediator of tubular inflammation and injury.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAPOBEC1BCL2-associated athanogene 4--Pubmed
HPRDapolipoprotein B mRNA editing enzyme isoform 1SODD--Pubmed
HPRDBcl 2BCL2-associated athanogene 4--Pubmed
BIND-BCL2-associated athanogene 4Bcl-2 interacts with BAG-4. This interaction was modelled on a demonstrated interaction between Bcl-2 from an unspecified species and human BAG-4.-Pubmed
HPRDB-cell lymphoma protein 2 alpha isoformSODD--Pubmed
HPRDHeat shock 70 KD protein 1ABCL2-associated athanogene 4--Pubmed
HPRDheat shock 70kDa protein 1ASODD--Pubmed
HPRDTumor necrosis factor receptor 1BCL2-associated athanogene 4--Pubmed
HPRDtumor necrosis factor receptor 1 precursorSODD--Pubmed
HPRDtumor necrosis factor receptor superfamily, member 25 isoform 2 precursorBCL2-associated athanogene 4--Pubmed

Recent Publications on BAG4:

Pubmed Logo
Identification of key regions and genes important in the pathogenesis of sezary syndrome by combining genomic and expression microarrays.
In this study, we used single nucleotide polymorphism and comparative...
22nd October, 2009
Istituto Dermopatico dell'Immacolata-Istituto di Ricovero e Cura a Cancer Res. 2009 Nov 1;69(21):8438-46. Epub 2009 Oct 20.
DOI Direct Link
Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma.
Cancer progression is associated with reduced apoptosis and increased...
2nd October, 2009
Section for Gynecologic Oncology, Division of Obstetrics and Gynecology, Int J Gynecol Pathol. 2009 May;28(3):211-21.
DOI Direct Link
Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer.
The 8p11-12 chromosome region is one of the regions most frequently...
19th September, 2008
UMR 144, Centre National de la Recherche Scientifique, Institut Curie, Cancer Res. 2008 Sep 1;68(17):7165-75.
DOI Direct Link
Expression of SODD and P65 in ALL of children and its relationship with chemotherapeutic drugs.
The expression of silence of death domains (SODD) and its clinical...
3rd July, 2008
Department of Pediatrics, Tongji Hospital, Tongji Medical College, J Huazhong Univ Sci Technolog Med Sci. 2007 Jun;27(3):326-9.
DOI Direct Link
BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer.
PURPOSE: We hypothesized that elevated expression in ovarian cancer of the...
1st February, 2008
Medical Oncology Branch,Center for Cancer Research, National Cancer Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6585-92.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6673908 Tumor necrosis factor receptor 2
5807852 Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
5728703 Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
5721236 Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
5719148 Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

View more patents.

BAG4 results (if any) from reagent suppliers

Google CSE Logo
SODD (H-300) Antibody sc-8980
Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, ... Overexpression of the 'silencer of death domain', SODD/BAG-4, modulates both ...
http://www.scbt.com/datasheet-8980-sodd-h-300-antibody.html...

Thumbshot
Polyclonal Antibody to BAG-3
2005)], BAG-3 (575 aa, 74 kDa), BAG-4 (456 aa; 60 kDa), BAG-5 ([442 aa; 51 kDa ( Kalia et al. 2004)], and BAG-6 (1129 aa; 150 kDa). IMG-5668 recognizes both ...
http://www.imgenex.com/tds/IMG-5676.pdf...

Thumbshot
Signal Transduction Antibodies :: Page 7
... XAV-8335, H, WB, Anti-β-Catenin. b-CATENIN [pS45] Antibody, XBP-4046, H, M, R, X, WB, b-CATENIN [pS45]. BAG4 Antibody, 46-977, H, E, WB, (IN) SODD ...
http://www.prosci-inc.com/shop/catalog1/Signal-Transduction-...

Thumbshot
Bag-1 (C-16) Antibody sc-939
Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for ...
http://www.scbt.com/datasheet-939-bag-1-c-16-antibody.html...

Thumbshot
Mouse TNF-α ELISA BMS607/2 BMS607/2TWO BMS607/2TEN
BAG4, Bcl2-associated athanogene 4) and association (TRADD = TNF-R1 associated death domain protein) and yielding the following biological activities: ...
http://www.bendermedsystems.com/bm_products/MAN/607-2.pdf...

Thumbshot
MicroFunnel™ ST Disposable Filter Funnels
(20 units total per box): 5 individually bagged funnels within an overpack bag; 4 overpack bags per box. ORDER NOW. ORDER NOW. Filter Funnel Manifolds ...
http://www.pall.com/laboratory_20046.asp...

Thumbshot
TNFRSF1A protein, TNFRI Human recombinant protein
Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and ... Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP
. ...
http://www.genwaybio.com/product_info.php?products_id=45158...

Thumbshot

Search Bioportfolio and other Life Science Sites for BAG4, or search for BAG4 on BioPortfolio's antibody search engine.
This page has been viewed 122 times
Recent Search Terms used to find this page:
Polyclonal goat Igg, N-19 BAG 4 | phospho-tnfr-S274 | SVR bag4 CRL-2387 | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.