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BAG3


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Gene DB Home
Symbol:BAG3
Name(s):BCL2-associated athanogene 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:BAG-3, BIS, CAIR-1, MGC104307
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18094623 HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy.
18006506 These results suggested that the HspB8-Bag3 complex might stimulate the degradation of Htt43Q by macroautophagy.
17996194 Taken together, our results suggest that BAG3 induction might represents as an unwanted molecular consequence of utilizing proteasome inhibitors to combat tumors.
17974966 High levels of BAG3 protein seen in some epithelial cancer cell lines may be relevant to mechanisms of tumor invasion and metastasis.
12706811 heavy metals and temperature regulate BAG3 gene expression.
12750378 findings suggest that heat shock protein-70 is a chaperone driving a multiprotein degradation complex and that the inhibitory co-chaperone CAIR-1 protein functions distal to client ubiquitination
17187345 These observations reveal a previously unrecognized cell response, that is, an increase in BAG3, elicited by HIV-1 infection, and may provide a new avenue for the suppression of HIV-1 gene expression.
17507989 The metabolic pathway of BAG3 was studied.
16859681 Results indicate that CAIR-1 may negatively regulate adhesion, focal adhesion assembly, signaling, and migration via its PXXP domain.
12700638 BAG3 protein has a role in apoptosis in B-chronic lymphocytic leukaemia cells

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBcl 2BCL2-associated athanogene 3--Pubmed
BIND-BCL2-associated athanogene 3Bcl-2 interacts with BAG-3. This interaction was modelled on a demonstrated interaction between Bcl-2 from an unspecified species and human BAG-3.-Pubmed
HPRDB-cell lymphoma protein 2 alpha isoformBCL2 associated athanogene 3--Pubmed
HPRDHeat shock 70 KD protein 1ABCL2-associated athanogene 3--Pubmed
HPRDheat shock 70kDa protein 1ABCL2 associated athanogene 3--Pubmed
HPRDHeat shock 70 kDa protein 8BCL2-associated athanogene 3--Pubmed
HPRDheat shock 70kDa protein 8 isoform 1BCL2 associated athanogene 3--Pubmed
HPRDPhospholipase C, gamma 1BCL2-associated athanogene 3--Pubmed
HPRDphospholipase C gamma 1 isoform aBCL2 associated athanogene 3--Pubmed

Recent Publications on BAG3:

Pubmed Logo
Identification of Novel Candidate Genes for Treatment Response to Risperidone and Susceptibility for Schizophrenia: Integrated Analysis Among Pharmacogenomics, Mouse Expression, and Genetic Case-Control Association Approaches.
BACKGROUND: Pharmacogenomic approaches based on genomewide sets of single...
24th October, 2009
MRC, Centre for Neuropsychiatric Genetics and Genomics, Department of Biol Psychiatry. 2009 Oct 21.
DOI Direct Link
Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction.
The molecular chaperone HspB8 is member of the B group of heat shock...
23rd October, 2009
Biochem J. 2009 Oct 21.
DOI Direct Link
Erythropoietin pre-treatment prevents cognitive impairments following status epilepticus in rats.
Selective neuronal loss is closely associated with cognitive impairments...
10th October, 2009
Department of Neurology, Xin Jiang Urumqi Military General Hospital, Brain Res. 2009 Jul 28;1282:57-66. Epub 2009 Jun 2.
DOI Direct Link
Transient expression of Bis protein in midline radial glia in developing rat brainstem and spinal cord.
Bis (Bcl-2 interacting death suppressor) has been reported to contribute...
3rd October, 2009
Department of Anatomy, College of Medicine, The Catholic University of Cell Tissue Res. 2009 Jul;337(1):27-36. Epub 2009 May 5.
DOI Direct Link
Autoregulation of co-chaperone BAG3 gene transcription.
The Bcl-2-associated athanogene, BAG, protein family through their BAG...
25th September, 2009
Department of Neuroscience, Center for Neurovirology, Temple University J Cell Biochem. 2009 Sep 23.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
5069872 Cutting tool
5351588 Hand shear
5411425 Floatation apparatus and methods
5787773 Hand shear

View more patents.

BAG3 results (if any) from reagent suppliers

Google CSE Logo
Bag3 antibody (ab5898) | Abcam
Goat polyclonal to Bag3. BAG proteins compete with Hip for binding to the Hsc70/ Hsp70 ATPase domain and promote substrate release. All the BAG proteins have ...
http://www.abcam.com/bag3-antibody-ab5898.html...

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Polyclonal Antibody to BAG-3
Increased BAG-3 expression has been described in pancretic cancer compared to normal pancreas, Detectible BAG-3 expression has ...
http://www.imgenex.com/tds/IMG-5676.pdf...

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Bag3 antibodies: Cancer > Invasion/microenvironment > Apoptosis ...
Bag3 antibodies. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab5898 · Bag3 antibody. Fast Track. Goat polyclonal ...
http://www.abcam.com/index.html?t=50285&pt=1&c=4240&ei=&mu=r...

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Bag Antibody / Bag Antibodies
Bag-3 (P-17) Antibody, sc-68954, goat IgG, Internal (h), WB, IF, ELISA, m, r, h ... Bag-3 shRNA Plasmid (h): sc-72602-SH. Bag-3 shRNA (h) ...
http://www.scbt.com/ko/table-bag.html...

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Search Results
別名: Anti-BAG3, Anti-BCL2-associated athanogene 3, Anti-BIS, Anti-CAIR1, Anti- MGC104307, Anti-BAG3, Anti-BCL2-associated athanogene 3, Anti-BIS, ...
http://www.sigmaaldrich.com/catalog/Lookup.do?D7=0&D10=&N17=...

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Bag-3 siRNA (m) sc-72603
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: Bag-3 ...
http://www.scbt.com/ko/datasheet-72603-bag-3-sirna-m.html...

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BAG2 antibody (ab752) | Abcam
The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high ...
http://www.abcam.com/bag2-antibody-ab752.html...

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