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BAG2


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Gene DB Home
Symbol:BAG2
Name(s):BCL2-associated athanogene 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:BAG-2, KIAA0576, MGC149462, dJ417I1.2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16207813 The activity of BAG-2 resembles that of the previously characterized Hsc70 cochaperone and CHIP inhibitor HspBP1.
16169850 BAG2 binds to the carboxyl terminus of Hsp70-interacting protein (CHIP) and provides a cochaperone-dependent regulatory mechanism for preventing unregulated ubiquitylation of misfolded proteins by CHIP
15271996 BAG2 was directly phosphorylated at serine 20 in vitro by MAPKAPK2 and MAPKAP2 is also required for phosphorylation of BAG2 in vivo.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDHeat shock 70 KD protein 1ABCL2-associated athanogene 2--Pubmed
HPRDheat shock 70kDa protein 1ABCL2 associated athanogene 2--Pubmed
HPRDHeat shock 70 kDa protein 8BCL2-associated athanogene 2--Pubmed
HPRDheat shock 70kDa protein 8 isoform 1BCL2 associated athanogene 2--Pubmed
HPRDBCL2-associated athanogene 2mitogen-activated protein kinase kinase kinase 7 interacting protein 2--Pubmed

Recent Publications on BAG2:

Pubmed Logo
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
Tau inclusions are a prominent feature of many neurodegenerative diseases...
17th April, 2009
Neuroscience Research Institute, University of California Santa Barbara, J Neurosci. 2009 Feb 18;29(7):2151-61.
DOI Direct Link
Proteome-wide identification of novel binding partners to the oncogenic fusion gene protein, NPM-ALK, using tandem affinity purification and mass spectrometry.
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), an oncogenic fusion...
20th February, 2009
Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada. Am J Pathol. 2009 Feb;174(2):361-70. Epub 2009 Jan 8.
DOI Direct Link
Induction of BAG2 protein during proteasome inhibitor-induced apoptosis in thyroid carcinoma cells.
BACKGROUND AND PURPOSE: Proteasome inhibitors exhibit cytotoxic against...
17th January, 2009
Department of Biochemistry & Molecular Biology, China Medical University, Br J Pharmacol. 2008 Nov;155(5):655-60. Epub 2008 Jul 28.
DOI Direct Link
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2.
Cochaperones are essential for Hsp70- and Hsc70-mediated folding of...
1st January, 2009
Department of Molecular Cardiology, Lerner Research Institute, NB50, 9500 Nat Struct Mol Biol. 2008 Dec;15(12):1309-17. Epub 2008 Nov 23.
DOI Direct Link
Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.
Epstein-Barr virus nuclear antigen 5 (EBNA5) is one of the first viral...
22nd August, 2008
Department of Clinical Chemistry and Transfusion Medicine, Institute of J Proteome Res. 2008 Jun;7(6):2309-19. Epub 2008 May 6.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
6399369 Multipotent neural stem cell cDNA libraries
6294346 Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
6094069 Semiconductor integrated circuit having controlled output resistance of an output buffer circuit
6087298 Exhaust gas treatment system

View more patents.

BAG2 results (if any) from reagent suppliers

Google CSE Logo
BAG2 antibody (ab752) | Abcam
Goat polyclonal to BAG2. BAG proteins compete with Hip for binding to the Hsc70/ Hsp70 ATPase domain and promote substrate release. All the BAG proteins have ...
http://www.abcam.com/bag2-antibody-ab752.html...

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Bag-2 (L-21) Antibody sc-130969
rabbit polyclonal IgG, 100µg/ml; recommended for detection of Bag-2 of m, r, ... Bag-2 (L-21): sc-130969. Western blot analysis of Bag-2 expression in ...
http://www.scbt.com/datasheet-130969-bag-2-l-21-antibody.htm...

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BAG2 antibodies: Cancer > Invasion/microenvironment > Apoptosis ...
BAG2 antibodies. ... BAG2 antibody [EPR3567]. Flow Cyt, ICC, IP, WB, IHC-P. Images. Rabbit monoclonal. Reacts with: Hu. ab80596 · BAG2 antibody [EPR3568]
...
http://www.abcam.com/index.html?t=8933&pt=1&c=4240&ei=&mu=ra...

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Bag-2 (A-12) Antibody sc-101216
mouse monoclonal IgG1, 100 µg/ml; raised against recombinant Bag-2 of human origin ... Western blot analysis of Bag-2 expression in HeLa whole cell lysate.
...
http://www.scbt.com/datasheet-101216-bag-2-a-12-antibody.htm...

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Polyclonal Antibody to BAG-3
BAG-1S , BAG-1M (RAP46/HAP46), and BAG-1L, BAG2, BAG3 (CAIR-1; Bis,), BAG4 (SODD ), ... BAG-2 [212 aa; 24 kDa (Arndt et al. 2005)], BAG-3 (575 aa, 74 kDa), ...
http://www.imgenex.com/tds/IMG-5676.pdf...

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Bag Antibody / Bag Antibodies
Bag-2 (A-12) Antibody, sc-101216, mouse IgG1, FL (h), WB, IP, ELISA, human. Bag- 2 (C-20) Antibody, sc-68948, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, ...
http://www.scbt.com/ko/table-bag.html...

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Bag3 antibody (ab5898) | Abcam
The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high ...
http://www.abcam.com/bag3-antibody-ab5898.html...

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