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BCAR1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18095869 |
focal adhesion kinase positively regulates Caco-2 spreading on collagen IV via p130(Cas) phosphorylation |
| 15923424 |
Our studies suggested that pRb2/p130-complexes bind to the ER-alpha promoter and could be involved in the transcriptional regulation of the ER-alpha gene by altering chromatin structure and DNA methylation pattern. |
| 17982677 |
Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion. |
| 16040804 |
p130Cas and paxillin function as effectors of GD3-mediated signaling, leading to such malignant properties as rapid cell growth and invasion in melanoma cells |
| 15448007 |
BCAR1 has a role in progression of primary breast cancer |
| 16597701 |
Fibronectin rigidity response involves force-dependent Fyn phosphorylation of p130Cas with rigidity-dependent displacement. |
| 11820787 |
Binding of the adapter protein p130Cas to the C-terminal of Pyk2 in cultured human umbilical vein endothelial cells is phosphorylation-independent and is not affected by acute exposure to thrombin. |
| 12397603 |
phosphorylation of p130(Cas) can prevent cells from anoikis and contribute to tumor cell anchorage independence and metastasis |
| 12738793 |
Requirement of the p130CAS-Crk coupling for metastasis suppressor KAI1/CD82-mediated inhibition of cell migration in a metastatic prostate cancer cell line. |
| 11779709 |
Tyrosine phosphorylation of p130CAS regulates localization and downstream signaling with profound affects on cell movement. | →View more information from publications. |
Recent Publications on BCAR1: |  |
Breast carcinoma cells in primary tumors and effusions have different gene array profiles.
The detection of breast carcinoma cells in effusions is associated with... | 15th August, 2009
| Department of Pharmacology and Experimental Therapeutics, School of
| J Oncol. 2010;2010:969084. Epub 2009 Aug 11.
DOI Direct Link |
Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens.
PURPOSE: AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3)... | 21st July, 2009
| Department of Medicine, Boston Medical Center, Boston, MA 2118, USA.
| Mol Vis. 2009;15:685-99. Epub 2009 Apr 3.
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B-MYB is required for recovery from the DNA damage-induced G2 checkpoint in p53 mutant cells.
In response to DNA damage, several signaling pathways that arrest the cell... | 15th July, 2009
| Department of Physiological Chemistry I, Biocenter, University of
| Cancer Res. 2009 May 1;69(9):4073-80. Epub 2009 Apr 21.
DOI Direct Link |
Expression of a phosphorylated p130(Cas) substrate domain attenuates the phosphatidylinositol 3-kinase/Akt survival pathway in tamoxifen resistant breast cancer cells.
Elevated expression of p130(Cas)/BCAR1 (breast cancer anti estrogen... | 15th July, 2009
| Department of Biochemistry, Boston University School of Medicine,
| J Cell Biochem. 2009 May 15;107(2):364-75.
DOI Direct Link |
Propofol inhibits pressure-stimulated macrophage phagocytosis via the GABAA receptor and dysregulation of p130cas phosphorylation.
Surgical stress and anesthesia result in systemic immunosuppression.... | 10th July, 2009
| John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan, USA.
| Am J Physiol Cell Physiol. 2009 Jun;296(6):C1400-10. Epub 2009 Apr 8.
DOI Direct Link |
→View more research publications. |
BCAR1 results (if any) from reagent suppliers | 
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BCAR1 antibody [M144] (ab31831) | Abcam
Mouse monoclonal [M144] to BCAR1. BCAR1 has a unique structure that contains a Src homology (SH)3 domain followed by multiple YXXP motifs and a proline rich
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http://www.abcam.com/BCAR1-antibody-M144-ab31831.html...
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C0354 Anti-p130CAS antibody produced in rabbit IgG fraction of ...
immunoprecipitation: suitable using human ECV304 cell lysate. microarray: suitable. Gene Information, human ... BCAR1(9564). rat ... Bcar1(25414) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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p130 Cas/Sin (N-17) Antibody sc-859
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, BCAR1, 9564, 16q23.1, NM_014567 ...
http://www.scbt.com/datasheet-859-p130-cas-sin-n-17-antibody...
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GeneTex Inc. - Your source for monoclonal, polyclonal, primary ...
PAb, WB, 100 μl, USD $269.00, -. BCAR1 antibody (breast cancer anti-estrogen resistance 1), GTX100605, Rabbit PAb, WB, 100 μl, USD $269.00, - ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...
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CRK antibody, v-crk sarcoma virus CT10 oncogene homolog (avian ...
Interacts with BCAR1, CBL, CBLB, PXN and GAB1 via its SH2 domain upon stimulus- induced tyrosine phosphorylation. ...
http://www.genwaybio.com/product_info.php?products_id=60296...
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Signal Transduction(1419) - GeneTex Inc. - Your source for ...
BCAR1 antibody (breast cancer anti-estrogen resistance 1), GTX100605, Rabbit PAb , WB, 100 μl, USD $269.00, -. BMP15 antibody (bone morphogenetic protein 15) ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...
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NG2 antibody [132.38] (ab50009) | Abcam
NG2 also stimulates alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. ...
http://www.abcam.com/NG2-antibody-132-38-ab50009.html...
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