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CD44


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Symbol:CD44
Name(s):CD44 molecule (Indian blood group)
Type:protein-coding
Organism:Homo sapiens
Synonyms:CDW44, CSPG8, ECMR-III, HCELL, IN, LHR, MC56, MDU2, MDU3, MGC10468, MIC4, MUTCH-I, Pgp1
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18214619 We believe that CD44s-mediated adhesion of malignant cells to other cells or to the extracellular matrix is responsible for the invasive features of biliary tract neoplasms, its aggressive progression, and its resistance to treatment.
18092951 Significance of CD44 expression in transitional cell carcinoma of the bladder and explanaion for results on the relationship between CD44 expression and the biological behaviour of urothelial cells.
18094716 The CD44 gene is silenced in NB4 acute promyelocytic leukemia cells by DNA methylation of a CpG island & underacetylation of histone H3 at the promoter. Brahma protein & phosphorylated RNA Pol II interact with the promoter region of CD44.
16415175 Observational study of gene-disease association. (HuGE Navigator)
18162778 staining for TCL1, CD38, and CD44 are useful ancillary tests to identify B-cell tumors
18193058 These findings establish that the HCELL glycoform of CD44 confers tropism to bone and unveil a readily translatable roadmap for programming cellular trafficking by chemical engineering of glycans on a distinct membrane glycoprotein.
18199543 Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44.
17945212 Results indicate that siRNA targeting a discrete sequence of human CD44 may provide a potential therapeutic option for colon cancer.
17945213 These findings indicate that the secretion of soluble CD44 contributes to colon cancer growth in vitro, possibly as a decoy receptor.
18155656 These are the first data to suggest a role for osteocytes and OPN in the recruitment of mesenchymal stem cells to aid in fracture repair.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCD4 antigen precursorCD44 antigen--Pubmed
HPRDCD4 antigen precursorCD44 antigen--Pubmed
HPRDCD4 antigen precursorCD44 antigen isoform 1 precursor--Pubmed
BIND-Homo sapiens putative lung tumor suppressor mRNA, complete cds.EPB41L3 (DAL-1) interacts with an unspecified isoform of CD44.-Pubmed
HPRDCD44Homo sapiens protein 4.1 mRNA, complete cds.--Pubmed
HPRDCD44heparin-binding EGF-like growth factor--Pubmed
HPRDCD44fibroblast growth factor 2--Pubmed
HPRDCD44protein-tyrosine kinase fyn isoform a--Pubmed
HPRDCD44matrix metalloproteinase 7 preproprotein--Pubmed
HPRDCD44T-cell lymphoma invasion and metastasis 1--Pubmed

Recent Publications on CD44:

Pubmed Logo
ADAM10 Is the Constitutive Functional Sheddase of CD44 in Human Melanoma Cells.
CD44 proteins are cell surface receptors for hyaluronic acid (HA), a...
31st October, 2008
1Department of Dermatology, Venerology and Allergology, Leipzig University J Invest Dermatol. 2008 Oct 30.
DOI Direct Link
RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53.
The receptor for hyaluronan-mediated motility RHAMM exerts different...
31st October, 2008
Molecular Oncology, Department of Obstetrics and Gynecology, and Cell Cycle. 2008 Nov 17;7(21).
Heterogeneous in vitro effects of doxorubicin on gene expression in primary human liposarcoma cell lines.
ABSTRACT: BACKGROUND: Doxorubicin is considered one of the most potent...
31st October, 2008
BMC Cancer. 2008 Oct 29;8(1):313.
DOI Direct Link
Multiparameter Analysis of CHO A(L) Mutant Populations Sorted on CD59 Expression after Gamma Irradiation.
Ross, C. D. and Fox, M. H. Multiparameter Analysis of CHO A(L) Mutant...
31st October, 2008
Radiat Res. 2008 Nov;170(5):628-37.
DOI Direct Link
Environmental Contaminant Trichloroethylene Promotes Autoimmune Disease and Inhibits T-cell Apoptosis in MRL(+/+) Mice.
The ability of environmental contaminant trichloroethylene to alter immune...
30th October, 2008
Department of Microbiology and Immunology, University of Arkansas for J Immunotoxicol. 2006 Dec 1;3(4):263-7.
DOI Direct Link

View more research publications.

BioNews Results for CD44

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Stem Cell Research - New stem cell research study results from Korea University described
NewsRX:  Nov 2 2008 1:53AM Matching: cd44
Data on colon cancer published by researchers at Osaka University
Calibre Macro World:  Oct 30 2008 11:53PM Matching: cd44
Platelet-derived RANTES mediates hypercholesterolemia-induced superoxide production and endothelial dysfunctio
MDLinx:  Oct 29 2008 7:59AM Matching: cd44
Researchers grow new prostate from single stem cell
World Health Network:  Oct 28 2008 2:26PM Matching: cd44
Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosi
MDLinx:  Oct 27 2008 3:25PM Matching: cd44
Promote your company here: BioNewsCast - Press Release Distribution

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Clinical Trials:

Clinical Trials Logo
Methylation Status of CD44 Promoter Region in Primary Lung Cancer
Non-Small Cell Lung Cancer

Patents:

Patents logo
US Patent No.Title
7407751 Methods for the detection and prognosis of breast tumors
7419665 Monoclonal antibodies for detection of urinary trypsin inhibitors
7419826 Human schwannoma cell line
7421347 Identifying oligonucleotides for in vitro recombination
7422883 Map kinase integrin-binding domain

View more patents.

CD44 results (if any) from reagent suppliers

Google CSE Logo
CD44 Antibody #3578
Polyclonal antibodies are produced by immunizing rabbits with a synthetic peptide (KLH-coupled) surrounding Leu135 of human CD44. Antibodies are purified
by ...
http://www.cellsignal.com/products/3578.html...

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CD44 antibodies | Abcam
CD44 antibodies. ... CD44 antibody [5035-41.1D] (FITC). Flow Cyt. Mouse monoclonal .... CD44 antibody [MEM-263] (Phycoerythrin) - Extracellular domain
...
http://www.abcam.com/index.html?t=14&pt=1&c=3290...

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APC/Cy7 Anti-mouse/human CD44 Antibody - BioLegend
APC/Cy7 Anti-mouse/human CD44 Antibody - CD44 is a 80-95 kD glycoprotein, also known as Hermes, Pgp1, H-CAM, or HUTCH.
http://www.biolegend.com/apc-cy7-anti-mouse-human-cd44-antib...

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CD44 antibody [MEM-263] (ab9524) datasheet | Abcam
Mouse monoclonal [MEM-263] to CD44. CD44 is a type 1 transmembrane glycoprotein also known as Phagocytic Glycoprotein 1 (pgp 1) and HCAM.
http://www.abcam.com/index.html?datasheet=9524...

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C7923 Monoclonal Anti CD44 antibody produced in mouse clone A3D8 ...
C7923 Monoclonal Anti-CD44 antibody produced in mouse clone A3D8, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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CD44 antibody (ab41478) datasheet | Abcam
See below for CD44 antibody images, references, products related to ab41478 and other tools. ... Price and availability of products related to CD44 antibody ...
http://www.abcam.com/index.html?datasheet=41478...

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mouse CD44 antibody: Functional Grade - no azide, azide free anti ...
eBioscience technical data sheet for product 16-0441 Functional Grade Purified anti-mouse/human CD44 (Pgp-1, Ly-24) IM7 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_16/16-...

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CD44 antibody (ab24504) datasheet | Abcam
Protocols for CD44 antibody. Price and availability of products related to CD44 antibody ... Contact Abcam with a Technical Enquiry about CD44 antibody ...
http://www.abcam.com/index.html?datasheet=24504...

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PE-Cy5.5 anti-human/mouse CD44 antibody: Phycoerythrin-Cy5.5 (Cy5 ...
eBioscience technical data sheet for product 35-0441 PE-Cy5.5 anti-mouse/human CD44 (Pgp-1, Ly-24) IM7 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_35/35-...

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CD44 Antibody CD44 isoform RC
CD44 antibody can be stored at 4C for short term (weeks) and -20C for long term. ,
http://www.prosci-inc.com/shop/catalog1/CD44-Antibody-p-1723...

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