Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18214619 |
We believe that CD44s-mediated adhesion of malignant cells to other cells or to the extracellular matrix is responsible for the invasive features of biliary tract neoplasms, its aggressive progression, and its resistance to treatment. |
| 18092951 |
Significance of CD44 expression in transitional cell carcinoma of the bladder and explanaion for results on the relationship between CD44 expression and the biological behaviour of urothelial cells. |
| 18094716 |
The CD44 gene is silenced in NB4 acute promyelocytic leukemia cells by DNA methylation of a CpG island & underacetylation of histone H3 at the promoter. Brahma protein & phosphorylated RNA Pol II interact with the promoter region of CD44. |
| 16415175 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18162778 |
staining for TCL1, CD38, and CD44 are useful ancillary tests to identify B-cell tumors |
| 18193058 |
These findings establish that the HCELL glycoform of CD44 confers tropism to bone and unveil a readily translatable roadmap for programming cellular trafficking by chemical engineering of glycans on a distinct membrane glycoprotein. |
| 18199543 |
Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44. |
| 17945212 |
Results indicate that siRNA targeting a discrete sequence of human CD44 may provide a potential therapeutic option for colon cancer. |
| 17945213 |
These findings indicate that the secretion of soluble CD44 contributes to colon cancer growth in vitro, possibly as a decoy receptor. |
| 18155656 |
These are the first data to suggest a role for osteocytes and OPN in the recruitment of mesenchymal stem cells to aid in fracture repair. |
| 18064740 |
Methylation may predict biochemical recurrence in prostate cancer patients undergoing radical prostatectomy. |
| 17987038 |
Finding identify OPN and CD44v6 as predictive markers of recurrence or aggressiveness in laryngeal intraepithelial neoplasia, and overall, point out an important signalling complex in the evolution of laryngeal dysplasia. |
| 17849363 |
Pesence of many CD44 isoforms, which cannot be distinguished with commercially used antibodies, but may play a different role in pathogenesis and spread of neuroblastoma. |
| 17940137 |
Multisite v3 splicing enhancer is functional irrespective of flanking intron length and spatial organization within v3. |
| 17479111 |
novel mechanism of apoptosis induction in Crohn disease mediated by CD44v7 ligation |
| 17726647 |
Signals from the extracellular association CD44-ezrin-actin are an important modulator of Fas-mediated apoptosis. |
| 17911438 |
CD44 targeting by antibody, passively injected into DBA/1 mice with collagen-induced arthritis (CIA) and NOD mice with type I diabetes or actively generated by CD44 cDNA vaccination of SJL/j mice with autoimmune encephalomyelitis[review] |
| 17702746 |
CD44 is an important regulator of HGF/c-Met-mediated in vitro and in vivo barrier enhancement, a process with essential involvement of Tiam1, Rac1, dynamin 2, and cortactin. |
| 17975002 |
CD44v6-positive sorted lymphangioleiomyomatosis cells showed loss of heterozygosity at the TSC2 locus; binding of CD44v6 antibody resulted in loss of cell viability. |
| 17708612 |
Fuzheng Yiliu granules enhance the immune adhesion function of RBCs and reduce the number of CD44(+)-cells in esophageal carcinoma patients. |
| 17482182 |
In endometrium, l-selectin is found in greater abundance in interstitial space than in epithelium. |
| 17599831 |
CD44-induced cell migration is dependent on its complex formation with Lyn and its consequent regulation of AKT phosphorylation in colon cancer cells. |
| 17516109 |
Loss of CD44 expression in gastrointestinal stromal tumors was associated with disease progression. |
| 17657222 |
AML1-ETO and its splice variant AML1-ETO9a regulate the expression of the CD44 gene, linking the 8;21 translocation to the regulation of a cell adhesion molecule that is involved in the growth and maintenance of the acute myeloid leukemia blast/stem cells |
| 15048167 |
CD44 was mainly expressed by the endothelial cells of high endothelial venules, fibroblasts in stromal compartments and large mononuclear cells.Its expression suggest that it participates in trafficking of leukocytes,especially lymphocytes to the omentum. |
| 17679465 |
CD44 may have an important role in the development of malignancy and in the determination of biological features of keratoacanthoma and squamous cell carcinoma of the skin. |
| 17540049 |
CD44+ breast cancer cells are successful in overcoming an engraftment incompatibility that exists when injecting human cells into mouse adipose tissue |
| 17611661 |
Low expression of CD44s is related to tumour cell invasiveness and may be of clinical relevance as a prognostic factor. |
| 17611662 |
Data indicate a positive association of CD44 expression with the malignant activities of CNE-2L2 cells and suggest a possible therapeutic effect of direct introduction of siRNA to CD44 into tumors in some solid tumors with high expression of CD44 gene. |
| 17581168 |
Two novel CD44 antigens of high incidence have been identified: IN3 (INFI) and IN4 (INJA) in the IN (Indian) blood group system. Lack of IN3 and IN4 results from homozygosity for mutations encoding H85Q and T163R in CD44, respectively. |
| 17627000 |
SolCD44 is elevated in the majority of head and neck cancer |
| 14644158 |
RhoA induced clustering of MMP-9 was observed in advancing lamellipodia at the forefront of endothelial cells, where this proteinase colocalized with RhoA and CD44 |
| 15013310 |
CD44 expression in renal allografts correlates with renal function. |
| 15516973 |
Osteopontin protein-binding activity was inhibited by the CD44 blocking antibody. |
| 15641486 |
High CD44 expression is associated with colorectal carcinomas |
| 15652352 |
CD44-mediated hyaluronan binding in myeloid cells is regulated by phosphorylated ERM and the actin cytoskeleton. |
| 12223485 |
Data suggest that intramembranous processing of CD44 occurs by a presenilin-1-dependent gamma-secretase activity at two distinct sites. |
| 14981907 |
CD44 variant isoforms on 55 transitional cell carcinoma tissue specimens were examined and expression of CD44v5 was inversely related to tumor grade |
| 12909589 |
CD44 is important for bronchial epithelial cell binding to hyaluronic acid and that cytokines known to be expressed in inflammation can increase binding independently of the level of CD44 expression. |
| 16504370 |
results suggest that CD44 splicing variants might play a role in the invasion of trophoblast into maternal tissue in early pregnancy |
| 11716065 |
Hyaluronate receptors mediate glioma cell migration and proliferation. The expression of the HA-receptors, CD44, and RHAMM, is virtually ubiquitous amongst glioma cell lines, and glioma tumor specimens. |
| 12748184 |
CD44 interaction with p115RhoGEF and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3-kinase membrane localization, AKT signaling, and cytokine (M-CSF) production during HA-mediated breast cancer progression |
| 15943035 |
after the 10-year follow-up, expression of CD44v7-v8 was associated with poor prognosis for breast cancer patients |
| 11740562 |
cd44 dependent group A Streptococcus binding to keratinocytes induce cytoskeletal rearrangements |
| 12842543 |
CD44v5 expression is independently positively correlated with the agressiveness of thymic epithelial tumors. |
| 16998483 |
BCR-ABL-expressing leukemic stem cells depend to a greater extent on CD44 for homing and engraftment than do normal hematopoietic stem cells |
| 16998484 |
CD44 is a key regulator of acute myeloid leukemic stem cells |
| 17135256 |
CD44 variant isoform (CD44v) is a functional P-selectin ligand on colon carcinoma, providing a novel perspective on the enhanced metastatic potential associated with tumor CD44v overexpression and the role of selectins in metastasis. |
| 15923644 |
TNF-alpha-induced CD44 expression was regulated by AP-1 through the activation of the CaMK-II pathway, whereas LPS-induced CD44 transcription was regulated specifically by Egr-1 through JNK activation. |
| 16636662 |
CD44 ligation triggers a novel caspase-independent cell death pathway via calpain-dependent AIF release in erythroleukemia cells. |
| 12574156 |
CD44 interaction with the alpha 1(IV)1263-1277 region from basement membrane collagen is modulated by ligand glycosylation |
| 17332338 |
OPN-CD44(V) interaction promotes ECM-derived survival signal mediated through integrin activation, which may play an important role in the pathogenic development and progression of gastric cancer. |
| 15816636 |
CD44v6 expression is associated with deep stromal invasion in cervical carcinoma |
| 15123640 |
Data suggest that hyaluronan-CD44 interaction with Rac1-protein kinase N gamma plays a pivotal role in phospholipase C gamma1-regulated calcium signaling and cortactin-cytoskeleton function required for keratinocyte cell-cell adhesion and differentiation. |
| 17237445 |
increased CD44, ezrin, radixin, and moesin phosphorylation represents a key molecular abnormality that guides T cell adhesion and migration in SLE patients. |
| 12711360 |
Review. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis. |
| 15867228 |
CD44 expression may be a favorable prognostic factor in patients with node-negative invasive breast carcinoma. |
| 17383158 |
study describes disease-specific CD44 variant expressed on synovial fluid cells of rheumatoid arthritis patients |
| 12826680 |
CD44 alternative v9 exon contains a splicing enhancer responsive to the SR proteins 9G8, ASF/SF2, and SRp20 |
| 15060082 |
The ability of TSG-6 to modulate the interaction of hyaluronan with CD44 has important implications for CD44-mediated cell activity at sites of inflammation, where TSG-6 is expressed. |
| 17589956 |
TNM staging, preoperative CEA and CD44v6 were independent prognostic factors for rectal cancer patients with total mesorectal excision. |
| 12421945 |
CD44 induction in THP-1 monocytic cells is the result of the distinct involvement of c-Jun N-terminal kinase (JNK) in lipopolysaccharide-mediated signaling and may require JNK-dependent activation of Egr-1. |
| 12702150 |
role of CD44 variant isoform v10 in adhesion of lymphocytes to melanoma cells |
| 16868940 |
Overexpression of CD44v6 is associated with early-onset gastric carcinomas |
| 12411303 |
results show that genes such as interleukin-6 (IL-6), IL-1alpha, and beta(2)-adrenergic receptor (beta(2)-AR) were specifically up-regulated by CD44 ligation, suggesting a novel role for CD44 in immunoregulation and inflammation |
| 12226094 |
CD44 spontaneously released from normal bronchial epithelial cells can accumulate as an integral component of the matrix, where it may play a role in the organization of matrices and in anchoring growth factors and chemokines to the matrix |
| 12650924 |
Crosslinking of CD44 on osteoblastic cells with specific antibodies augmented the expression of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 |
| 14614016 |
high CD44 expression is associated with mucinous epithelial ovarian cancer |
| 15040016 |
Heparanase, CD44v6 and nm23 may play important roles in the invasive infiltration and lymph node metastasis in gastric carcinomas |
| 14534711 |
CD44 v6 has a role in metastatic potential of carcinoma cells increasing the migration capacity and participating in invasion via changes in adhesion to the extracellular ligands, but is not necessary to modify the clinical history of the metastases |
| 14534719 |
CD44v6 is upregulated in transformated colon cancer cells |
| 16219515 |
human cervical CD44 mRNA expression is induced by interleukin-1beta so hyaluronic acid in the cervical tissue is increased because of the expression of CD44 |
| 16208414 |
CD44 ligation by MAb induces activation of both initiator caspase-8 and -9 and effector caspase-3 and -7; but only inhibition of caspase-3/7 and caspase-8 reduces CD44 ligation-induced apoptosis |
| 15638368 |
CD44 variant 4 may influence the progression of colorectal cancer. |
| 12145287 |
CD44 interaction with the TGF-betaRI kinase promotes activation of multiple signaling pathways required for ankyrin-membrane interaction, tumor cell migration, and oncogenic events during HA and TGF-beta-mediated metastatic breast tumor progression |
| 12145196 |
CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. |
| 14504094 |
CD44-hyaluronic acid interactions may contribute to lymphocytotropism to skin in acute GVHD. |
| 14669354 |
Detection of PCNA and CD44mRNA expression in colorectal cancer may be useful for evaluating liver metastasis of cancer cells. |
| 15558018 |
The conserved binding ability of the Hemopexin domains suggests that CD44 may act as a core molecule assembling multiple Membrane-type 1 matrix metalloproteinases on the cell surface. |
| 12032545 |
A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility. |
| 12235127 |
Hyaluronan-CD44 interaction inhibits migration of osteoclast-like cells by down-regulating MMP-9. |
| 15239258 |
CD44 expression in primary lesions is related to higher frequency of extrahepatic metastasis. This may be clinicopathologically useful parameter in predicting occurrence of distant metastasis. |
| 14623895 |
cleavage of CD44 catalyzed by ADAM10 is augmented by the intracellular signaling elicited by engagement of CD44, through Rac1-mediated cytoskeletal rearrangement, and suggest that CD44 cleavage contributes to the migration and invasion of tumor cells |
| 12479099 |
Increase of CD44s, MMP-9, and Ki-67 were involved in the growth and local invasion of osteosarcoma. |
| 12635659 |
expressed by cells of the oligodendrocyte lineage in vitro and by oligodendrogliomas in vivo; could play a role in migration of tumor cells in oligodendrocytic tumors |
| 15509527 |
CD44 variants have roles in a feedback loop in endothelial cells in human atheroma and abdominal aortic aneurysm |
| 15809746 |
CD44 and membranous E-cadherin expression were correlated with the depth of primary tumour invasion. |
| 16554035 |
We conclude that cell matrix factors act cooperatively with cytokines to induce the expression of the components of the NADPH-oxidase in monocytic progenitor cells. |
| 16809345 |
Results suggest that hyaluronan suppresses PDGF beta-receptor activation by recruiting a CD44-associated tyrosine phosphatase to the receptor. |
| 16969488 |
up-regulated CD44s expression in metastases is associated with a shorter disease-free survival of colorectal neoplasms |
| 17092940 |
N-WASP plays a pivotal role in regulating hyaluronan-mediated CD44-ErbB2 interaction, beta-catenin signaling, and actin cytoskeleton functions that are required for tumor-specific behaviors and ovarian cancer progression |
| 17265493 |
Chondrocytes with low chondrogenic capacity expressed higher levels of IGF-1, MMP-2, aggrecanase 2, while chondrocytes with high chondrogenic capacity expressed higher levels of CD44, CD151, and CD49c. |
| 17343740 |
CD44 surface expression is an important event in the activation of MMP-9 and migration of prostate cancer cells. |
| 17579117 |
claudin-7-associated EpCAM is recruited into (tetraspanin-enriched membrane microdomains) and forms a complex with CO-029 and CD44v6 that facilitates metastasis formation |
| 11840273 |
variant isoforms involved in plasma cell adhesion to bone marrow stromal cells and in the multiple myeloma disease process |
| 12297287 |
Engagement of CD44 either by its natural ligand hyaluronan or a specific antibody on a cell line induced tyrosine phosphorylation and activation of focal adhesion kinase. |
| 12730955 |
that Src contributes in part to malignant peripheral nerve sheath tumor cell invasion by increasing CD44 levels. |
| 15017146 |
NMR analysis of the hyaluronan-binding domain of CD44 |
| 12893366 |
CD44 expression correlates with T stage in renal cell carcinoma, although this correlation does not reach statistical significance; no association of CD44 expression with survival is found in renal cell carcinoma patients who underwent nephrectomy. |
| 15531362 |
CD44 expression identifies astrocyte-restricted precursor cells. |
| 16354706 |
SRm160, a splicing coactivator, regulates CD44 alternative splicing in a Ras-dependent manner. |
| 16565089 |
CD44 interaction with LARG and EGFR plays a pivotal role in Rho/Ras co-activation, PLC epsilon-Ca2+ signaling, and Raf/ERK up-regulation required for CaMKII-mediated cytoskeleton function and in head and neck squamous cell carcinoma progression |
| 16652145 |
functional experiments, tet-regulated induction of CD44s potentiated the migration and invasion of MCF7F cells through HA-supplemented Matrigel |
| 16702221 |
CD44-hyaluronan (HA) interaction is involved inand leukocyte adhesion. |
| 12506143 |
Crystal retention in human kidney may depend on expression of CD44 antigen-, osteopontin-, and hyaluronic acid-rich cell coats by damaged distal tubular epithelium. |
| 12629514 |
Our present findings suggest important implications for understanding CD44-dependent signal transduction and a potential role of PS/gamma-secretase activity in the functional regulation of adhesion molecules. |
| 15361838 |
Recombinant CD44-hyaluronic acid binding domain represents a novel class of angiogenesis inhibitors based on a cell-surface receptor. |
| 16325770 |
Taken together, engagement of CD44 (e.g., hyaluronan) and glycated albumin induced the differentiation of resting monocytes into foam macrophages through the induction of MSRs. |
| 16390331 |
EGF induces ADAM10-mediated CD44 cleavage through Rac1 and mitogen-activated protein kinase activation, and thereby promotes tumour cell migration and invasion. |
| 12168806 |
CD44 has a functional role in inflammatory processes and tumor susceptibility |
| 16419149 |
Data suggest that CD44 expression level is linked to the cell cycle in gastrointestinal tumor cells, which in turn leads to cell cycle dependent alterations of their adhesion behaviour to endothelium. |
| 12407110 |
exon v10-encoded B[X(7)]B motif is solely responsible for the enhanced adhesive activity of exon v10-containing CD44 isoforms |
| 11727257 |
Expression in uterine smooth muscle tumors |
| 15023889 |
Maximal CD44 expression on isolated monocytes is decreased in patients with a poor collateralization compared with patients with a good collateralization. |
| 15736104 |
data obtained with human arterial smooth muscle cells in vitro support a role of CD44 in the smooth muscle cell response to the metabolic and hormonal disorders of diabetes |
| 12371152 |
reduction in the expression of CD44 may confer growth advantage and malignant properties to tumour cells |
| 12090473 |
TNFalpha and IL-8 regulate the expression and function of CD44 variant proteins in human colon carcinoma cells. |
| 12511569 |
regulation of interaction with hyaluronan by E-cadherin and role in mediating tumor invasion and branching morphogenesis |
| 12928429 |
analysis of the hyaluronan recognition mode of CD44 |
| 16085055 |
Function of tumor-derived soluble CD44, like the transmembrane form of the receptor, can be regulated. |
| 16166750 |
Patients who later developed renal allograft rejection had statistically significantly increased soluble CD44 levels, but not soluble ICAM-1, IL-2R or CRP in plasma prior to transplantation. |
| 16407205 |
These results are consistent with the concept that tumor cells generate hyaluronan oligosaccharides that bind to tumor cell CD44 through the expression of their own constitutive hyaluronidases. |
| 16478744 |
CD44 was methylated in the prostatic tumor epithelium from four of the five patients but not in the tumor stroma. |
| 17392272 |
an effect of CD44 on tumor cell motility may depend in part on its ability to partner with additional proteins, such as cell surface Rhamm. |
| 11792412 |
sCD44 levels could be a useful prognostic marker for aggressive lymphoma |
| 11825898 |
Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack. |
| 12779084 |
Higher relative expression of SR55 protein was associated with an altered pattern of CD44 variants incorporating exon v7 as determined by reverse transcription-polymerase chain reaction (RT-PCR) and Southern blot analysis. |
| 11839564 |
wide prevalence of CD44 cleavage suggests that it plays an important role in the pathogenesis of human tumors |
| 12485845 |
Antagonistic signaling pathways regulate alternative splicing in T cells. |
| 12198147 |
Initial steps of Shigella binding and cell entry depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction. |
| 12439723 |
Butyrate significantly inhibited transcription of the CD44 gene and abolished epidermal growth factor-mediated up-regulation of the reporter gene luciferase subcloned upstream to the CD44 promoter (-1.1 kb) and transfected to HM7 cells |
| 12908752 |
The expression of CD44 standard in 30 oligodendrogliomas was studied in order to verify its possible prognostic role. CD44H could have prognostic value regarding the occurrence of relapses. |
| 17085435 |
The order-to-disorder transition of the carboxyl-terminal region by hyaluronan binding may be involved in CD44-mediated cell migration. |
| 17136494 |
interaction between membrane-bound hyaluronan and the cell surface CD44 was involved in the up-regulation of FasL expression on T cells and subsequent activation-induced cell death |
| 11759056 |
results suggest that CD44S and CD44v5 are differentially expressed in early and advanced ovarian serous carcinomas and support previous studies that suggest a role for CD44 and stromal hyaluronic acid in the dissemination of ovarian epithelial cancer |
| 12727228 |
Data demonstrate that blockade of the ERK pathway suppressed the expression of matrix metalloproteinases 3, 9, and 14, and CD44, and markedly inhibited the invasiveness of tumor cells. |
| 12801931 |
hydrolysis by hyaluronan oligosaccharides |
| 15292257 |
alpha2beta1 integrin and CD44/CSPG receptor binding on human melanoma cell activation has been evaluated herein using triple-helical peptide ligands incorporating collagen peptides. |
| 15728517 |
Engagement of CD44 mediates deactivation of human monocytes in the presence of tumor cells, an effect apparently involved in IL-1 receptor associated kinase-M (IRAK-M) up-regulation. |
| 16002044 |
Serine 180 is the site for chondroitin sulfate addition in CD44H and that this negatively regulates hyaluronan binding. |
| 16177123 |
CD44 is part of the putative cell surface vitamin D binding protein binding site complex and functions to mediate the chemotactic cofactor effect. |
| 16352650 |
variant isoforms of CD44 on LS174T colon carcinoma cells possess selectin binding activity, in contrast to the standard isoform of CD44 on hematopoietic-progenitor cells. |
| 12183053 |
a signal transduction cascade or cross-talk emanating from CD44 to c-Met |
| 12820426 |
Expressions of CD44s and CD44v6 play an important role in tumor progression. |
| 15009704 |
dermatan sulfate-CD44H proteoglycan is essential for fibroblast migration into fibrin clots and that platelet-derived growth factor, the stimulus for migration, induces the production of chondroitin-sulfate- and dermatan-sulfate-glycanated CD44H. |
| 15313120 |
role in tumor induced angiogenesis |
| 12949055 |
CD44v6 expression and cell adhesion in HepG2 cells depends on osteopontin |
| 12883358 |
Post-translational modification of CD44s represents the principal regulatory mechanism of CD44s-mediated functions in melanoma. |
| 15578568 |
modulating role of CD44 in osteoclast formation appears to depend on the microenvironment |
| 12393872 |
Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates antigen in cox-2-dependent invasion |
| 12767055 |
The presence of Abeta 1-40 fragment, alone or in combination with IL1beta, induced an increase in the percentage of cells expressing CD44 |
| 15783086 |
We conclude that CD44v6 expression correlates with a higher proliferative activity and with a stem cell-like phenotype in both cell lines and with cellular atypia in HT1197 cells. |
| 16234326 |
Directional migration of breast cancer cells towards hyaluronan is dependent on CD44 |
| 16530165 |
There is a cryptic splice site, in intron 6 of the human CD44 gene, used during mRNA processing. |
| 16533775 |
Increased CD44 antigen is associated with relapses in non-small cell lung cancers |
| 16713680 |
Hyaluronidase and CD44 hyaluronan receptor are expressed in squamous cell laryngeal carcinoma |
| 17464868 |
Cell adhesion protein CD44 (especially CD44v6 isoform) expression was up-regulated in cervical carcinoma associated with humanpapillomavirus (HPV) infection |
| 17638891 |
CD44+alpha2beta1+ cell population is enriched in tumor-initiatin prostate cancer cells |
| 12452061 |
studied CD44v6 expression in intraductal papilloma, and its malignant transformation, intraductal breast carcinoma |
| 12911725 |
We conclude that the cell adhesion molecule CD44 is expressed infrequently in papillary serous endometrial carcinoma. |
| 12508241 |
CD44 silencing is controlled in part by a complex and tumor cell-specific process involving hypermethylation of the CD44 gene promoter and exon 1 regions. |
| 15645378 |
statistical relationship found between HPV16 infection and the expression of CD44v6 in esophageal squamous cell carcinoma |
| 15990174 |
CD44 and CD49d are putative activity markers and CD44 a potential novel therapeutic target in multiple sclerosis. |
| 16229685 |
The cleavage of the ectodomains of L1 and CD44 is initiated in an endosomal compartment that is subsequently released in the form of exosomes. |
| 16565092 |
expression of HCELL confers robust and predominant tumor cell binding to E- and L-selectin |
| 16620830 |
An IL-6-CD44 feedback loop in macrophages may aggravate atherosclerosis development. |
| 15962382 |
measurement of CD44v6 expression in peripheral blood by RT-PCR is not suitable for detection of circulating tumor cells. |
| 15638386 |
CD44v10 takes part in local cancer progression. (CD44v10) |
| 11935029 |
In mice, CD44 plays a role in resolving the inflammatory response following lung injury by clearance of inflammatory hyaluronan fragments, clearance of apoptotic PMNs, and generation of active TGFbeta 1. |
| 11466334 |
Interaction of CD44 when cross-linked on rheumatoid synovial cells with hyaluronan fragments present in the surrounding extracellular matrix augments Fas expression and Fas-mediated apoptosis of synovial cells. |
