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CD47


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Gene DB Home
Symbol:CD47
Name(s):CD47 molecule
Type:protein-coding
Organism:Homo sapiens
Synonyms:IAP, MER6, OA3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17572512 Upregulation of CD47 in sporadic inclusion body myositis.
16697668 highlight major species differences in CD47-SIRPalpha interactions and CD47 integration, suggesting that signaling by CD47 in man may be qualitatively different from mouse.
14966135 CD47 recruits alpha(v)beta(3) and its associated signaling molecules to these domains
17360380 Genetic induction of human CD47 on porcine cells could provide inhibitory signaling to SIRPalpha on human macrophages, providing a novel approach to preventing macrophage-mediated xenograft rejection.
15292185 CD47 has a role in inducing alpha4beta1 integrin activation and adhesion in sickle reticulocytes
12370491 An autocrine loop of the integrin alpha(V)beta(3)/CD47 receptor complex and thrombospondin-1 is identified as the molecular coupling device between mechanical loading and apoptosis.
11980922 Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior
12736272 the extracellular Ig domain of IAP(CD47), when bound to thrombospondin, interacts with integrin alphaIIbbeta3 and can change alphaIIbbeta3 in a high affinity state without the requirement of intracellular signaling
17363705 In this review the authors provide mechanistic insight into the signaling pathways used by thrombospondin-1 and CD47 at the cellular and molecular level to prevent nitric oxide signaling through cyclic GMP, thereby exacerbating tissue ischemia.
12609828 CD47 expressed on platelets significantly contributes to platelet adhesion on tumor necrosis factor-alpha (TNF-alpha)-stimulated vascular endothelial cells

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBCL2/adenovirus E1B 19kD-interacting protein 3CD47 antigen isoform 1 precursor--Pubmed
HPRDBCL2/adenovirus E1B 19kD-interacting protein 3CD47 antigen isoform 1 precursor--Pubmed
HPRDCD47Rh-associated glycoprotein--Pubmed
HPRDCD47integrin alpha-V precursor--Pubmed
HPRDCD47PTK2 protein tyrosine kinase 2 isoform b--Pubmed
HPRDCD47 antigen isoform 1 precursorRhesus blood group associated glycoprotein--Pubmed
HPRDCD47 antigen isoform 1 precursorFAK--Pubmed
HPRDCD47 antigen isoform 1 precursorIntegrin alpha V--Pubmed
HPRDCD47 antigen isoform 1 precursorErythrocyte band 4.2 protein--Pubmed
HPRDCD47 antigen isoform 1 precursorguanine nucleotide binding protein, alpha inhibiting activity polypeptide 1--Pubmed

Recent Publications on CD47:

Pubmed Logo
Leishmania donovani-induced expression of SIRPalpha on kupffer cells enhances hepatic invariant NKT cell activation.
SIRPalpha and its cognate ligand CD47 have been documented to have a broad...
31st October, 2009
Centre for Immunology and Infection, Hull York Medical School and Eur J Immunol. 2009 Oct 28.
DOI Direct Link
Decreased CD47 expression during spontaneous apoptosis targets neutrophils for phagocytosis by monocyte-derived macrophages.
BACKGROUND: Neutrophils (PMN) are the primary leukocyte responders during...
10th October, 2009
Department of Pediatrics, Division of Neonatology, Saint Louis University Early Hum Dev. 2009 Oct;85(10):659-63. Epub 2009 Oct 7.
DOI Direct Link
CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.
Microglia are the brain's tissue macrophages and are found in an activated...
10th October, 2009
Department of Neurosciences, Center for Global Health and Diseases, Case J Neurosci. 2009 Sep 23;29(38):11982-92.
DOI Direct Link
CD47 and TLR-2 cross-talk regulates neutrophil transmigration.
Neutrophil (PMN) infiltration into tissues is a hallmark of acute...
9th October, 2009
Epithelial Pathobiology Unit, Department of Pathology and Laboratory J Immunol. 2009 Nov 1;183(9):5957-63. Epub 2009 Oct 7.
DOI Direct Link
Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells.
Major clinical issues in bladder cancer include the identification of...
9th October, 2009
Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14016-21. Epub 2009 Aug 4.
DOI Direct Link

View more research publications.

BioNews Results for CD47

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Nov. 3, 2009--NIC Announces Genomic, Personalized Medicine Grants
Advance for Imaging & Radiation Oncology:  Nov 4 2009 4:19AM Matching: cd47
Nov. 3, 2009--MSU Team Lands Grant for Breast Cancer Survivorship Program
Advance for Imaging & Radiation Oncology:  Nov 4 2009 4:19AM Matching: cd47
Nov. 2, 2009--ASCO Launches International Cancer Corps
Advance for Imaging & Radiation Oncology:  Nov 4 2009 4:19AM Matching: cd47
Radiation Treatments Made Safer for Cancer Patients
MedicineNet.com:  Oct 29 2009 2:48AM Matching: cd47
NCI Developes a Method that Protects Healthy Tissues from the Damaging Effects of Radiation
Medicexchange.com:  Oct 26 2009 11:04PM Matching: cd47
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Patents:

Patents logo
US Patent No.Title
7011953 Diagnostic assay for type 2 heparin-induced thrombocytopenia
7282556 Polynucleotides and polypeptides relating to the modulation of SIRP.alpha.-CD47
7288569 Lipoxin compounds and their use in treating cell proliferative disorders
7308364 Diagnosis of multiple myeloma on gene expression profiling
7371734 Oligonucleotide compositions and their use for the modulation of immune responses

View more patents.

CD47 results (if any) from reagent suppliers

Google CSE Logo
CD47 Antibody / CD47 Antibodies
CD47 Antibody / CD47 Antibodies. ... CD47 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-cd47.html...

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Alexa Fluor 647 Anti-mouse CD47 Antibody Anti-CD47 - BioLegend
Alexa Fluor 647 Anti-mouse CD47 Antibody Anti-CD47 - CD47, also known as Integrin-Associated Protein (IAP) ,is a membrane protein of about 50 kd with an
...
http://www.biolegend.com/alexa-fluor-647-anti-mouse-cd47-ant...

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CD47 antibody [B6H12.2] (ab3283) | Abcam
Mouse monoclonal [B6H12.2] to CD47. CD47 antigen, also known as integrin associated protein (IAP), has a very broad tissue distribution.
http://www.abcam.com/CD47-antibody-B6H12-2-ab3283.html...

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CD47 (B6H12) Antibody sc-12730
See how others have used CD47 (B6H12): sc-12730 antibody and or CD47 (B6H12) ... Western blot analysis of CD47 expression in non-transfected: sc-110760 (A) ...
http://www.scbt.com/datasheet-12730-cd47-b6h12-antibody.html...

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The Abcam catalog
CD47 antibodies. ... CD47 antibody [HCD47] (FITC). Flow Cyt. Mouse monoclonal ... CD47 antibody [OX-101]. Flow Cyt, WB, FuncS, IP. Mouse monoclonal ...
http://www.abcam.com/index.html?t=4139&pt=1&c=3290...

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PerCP/Cy55 Anti-human CD47 Antibody Anti-CD47 - BioLegend
PerCP/Cy55 Anti-human CD47 Antibody Anti-CD47 - CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, ...
http://www.biolegend.com/percp-cy55-anti-human-cd47-antibody...

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mouse CD47 antibody, Allophycocyanin (APC) conjugate
eBioscience technical data sheet for product 17-0471 Allophycocyanin (APC) anti- mouse CD47 miap301 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_17/17-...

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