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NCOR1
| Symbol: | NCOR1 | | Name(s): | nuclear receptor co-repressor 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | KIAA1047, MGC104216, N-CoR, TRAC1, hCIT529I10, hN-CoR | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17768398 |
Data support a role for N-CoR in erythroid differentiation and suggest that N-CoR is required for the induction of a key enzyme involved in heme synthesis. |
| 15802375 |
N-CoR and SMRT play an active role in preventing tamoxifen from stimulating proliferation in breast cancer cells through repression of a subset of target genes involved in ERalpha function and cell proliferation |
| 11903058 |
Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation |
| 15598662 |
NCoR is a physiological regulator of the AR; the N-terminal surface of the AR-mediating NCoR recruitment was distinct from tau5 and from the FXXLF motif that mediates agonist-induced N-C-terminal interaction |
| 15561719 |
THAP7 coimmunoprecipitates with histone deacetylase 3 and the nuclear hormone receptor corepressor and represses transcription |
| 16373395 |
SMRT and N-CoR corepressors are involved in transcriptional regulation by both agonist- and antagonist-bound AR and regulate the magnitude of hormone response, at least in part, by competing with coactivators. |
| 15695367 |
the DAD domain of N-CoR is singularly essential for repression by the thyroid hormone receptor |
| 16914745 |
The repression mechanisms by the nuclear receptor corepressor (N-CoR) of steroid hormone receptor (SHR)-mediated transactivation were examined. |
| 15761026 |
the N-CoR/HDAC3 complex has a role in regulating the expression of genes involved in circadian rhythm by functioning as corepressor for Rev-erbalpha |
| 15377655 |
N-CoR utilizes repression domains I and III for interaction and co-repression with ETO | →View more information from publications. |
Recent Publications on NCOR1: |  |
Nuclear receptor co-repressor is required to maintain proliferation of normal intestinal epithelial cells in culture and down-modulates the expression of pigment epithelium-derived factor.
Stem cells of the gut epithelium constantly produce precursors that... | 3rd November, 2009
| Departement d'Anatomie et Biologie Cellulaire, Faculte de Medecine et des
| J Biol Chem. 2009 Sep 11;284(37):25220-9. Epub 2009 Jul 16.
DOI Direct Link |
Retinoic acid mediates long-paced oscillations in retinoid receptor activity: evidence for a potential role for RIP140.
BACKGROUND: Mechanisms that underlie oscillatory transcriptional activity... | 29th October, 2009
| Department of Pharmacology and Toxicology, Hanover, New Hampshire, USA.
| PLoS One. 2009 Oct 28;4(10):e7639.
DOI Direct Link |
Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling.
The human hyaluronan synthase 2 (HAS2) gene encodes for an enzyme making... | 29th October, 2009
| Department of Bioscience, of Kuopio, FIN-70211 Kuopio, Finland.
| J Biol Chem. 2009 Jul 3;284(27):18270-81. Epub 2009 May 5.
DOI Direct Link |
Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene.
As a partner of cyclin-dependent kinase (CDK) 3, Cyclin C controls... | 21st October, 2009
| Department of Biosciences, University of Kuopio, Finland.
| J Mol Biol. 2009 Oct 23;393(2):261-71. Epub 2009 Aug 14.
DOI Direct Link |
Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse.
BACKGROUND: Estrogen receptor alpha (ER alpha) is the most important... | 29th September, 2009
| Department of Breast and Endocrine Surgery, Faculty of Medical and
| Chin Med J (Engl). 2009 Aug 5;122(15):1764-8.
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→View more research publications. |
NCOR1 results (if any) from reagent suppliers |
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NCOR1 Antibody (N-term)
#AP1121a) is used in Western blot to detect NCOR1 in mouse thymus tissue lysate. NCOR1 Antibody (N-term). Formalin-fixed and paraffin-embedded human cancer ...
http://www.abgent.com/products/catalog_no/AP1121a_NCOR1_Anti...
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BIOMOL International - HDAC3/NCOR1 Complex (human, recombinant)
Produced by coexpression of HDAC3 with a GST-NCOR1(DAD) construct in an insect cell system, the complex displays ~100-fold higher deacetylase activity than ...
http://www.biomol.com/?pageId=38&categoryId=225&productId=35...
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NCOR1 Antibody (C-term)
Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein kinases ...
http://www.abgent.com/products/catalog_no/AP1121b_NCOR1_Anti...
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HDAC3/NCOR1 Complex (human, recombinant) CATALOG NO.: BML-SE515 ...
3) Add 5 µl of diluted HDAC3/NCOR1 Complex (BML-SE515, 5 ng/µl) to the wells for the 0 min, 30 min, and 30 min. plus trichostatin ...
http://www.biomol.com/SiteData/docs/ProductData/SE515.pdf...
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Protein Modification / Acetylation - Protein Modification Antibody
AP1121a, NCOR1 Antibody (N-term), WB, IHC, E, H, M. AT2997a, NDST3 monoclonal antibody (M01), ELISA,S-ELISA,WB-Ce,WB-Re, H. AP1925a, NOC2L Antibody (Center) ...
http://www.abgent.com/products/category/protein_modification...
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N-CoR (H-303) Antibody sc-8994
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, NCOR1, 9611, 17p12, NM_006311 ...
http://www.scbt.com/datasheet-8994-n-cor-h-303-antibody.html...
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Abgent Antibodies and Peptides
AP1121a, NCOR1 Antibody (N-term), O75376 · AP1109a, HDAC9 Antibody (N-term), Q9UKV0 · AM7099a, PARK8 (LRRK2) Antibody, Q5S007 ...
http://www.abgent.com/docs/abgent_newsletter_2007_jan...
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