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NCOR1


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Symbol:NCOR1
Name(s):nuclear receptor co-repressor 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:KIAA1047, MGC104216, N-CoR, TRAC1, hCIT529I10, hN-CoR
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17768398 Data support a role for N-CoR in erythroid differentiation and suggest that N-CoR is required for the induction of a key enzyme involved in heme synthesis.
15802375 N-CoR and SMRT play an active role in preventing tamoxifen from stimulating proliferation in breast cancer cells through repression of a subset of target genes involved in ERalpha function and cell proliferation
11903058 Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation
15598662 NCoR is a physiological regulator of the AR; the N-terminal surface of the AR-mediating NCoR recruitment was distinct from tau5 and from the FXXLF motif that mediates agonist-induced N-C-terminal interaction
15561719 THAP7 coimmunoprecipitates with histone deacetylase 3 and the nuclear hormone receptor corepressor and represses transcription
16373395 SMRT and N-CoR corepressors are involved in transcriptional regulation by both agonist- and antagonist-bound AR and regulate the magnitude of hormone response, at least in part, by competing with coactivators.
15695367 the DAD domain of N-CoR is singularly essential for repression by the thyroid hormone receptor
16914745 The repression mechanisms by the nuclear receptor corepressor (N-CoR) of steroid hormone receptor (SHR)-mediated transactivation were examined.
15761026 the N-CoR/HDAC3 complex has a role in regulating the expression of genes involved in circadian rhythm by functioning as corepressor for Rev-erbalpha
15377655 N-CoR utilizes repression domains I and III for interaction and co-repression with ETO

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDandrogen receptor isoform 1nuclear receptor co-repressor 1--Pubmed
HPRDandrogen receptor isoform 1nuclear receptor co-repressor 1--Pubmed
HPRDB-cell lymphoma 6 proteinnuclear receptor co-repressor 1--Pubmed
HPRDB-cell lymphoma 6 proteinnuclear receptor co-repressor 1--Pubmed
HPRDETOnuclear receptor co-repressor 1--Pubmed
BINDacute myelogenous leukemia 1 translocation 1 protein isoform MTG8anuclear receptor co-repressor 1ETO interacts with N-CoR.-Pubmed
HPRDacute myelogenous leukemia 1 translocation 1 protein isoform MTG8bNuclear receptor corepressor 1--Pubmed
BINDHomo sapiens chromosome 12nuclear receptor co-repressor 1NcoR interacts with the CCND2 promoter region.-Pubmed
BINDHomo sapiens chromosome 9nuclear receptor co-repressor 1NCOR1 (N-CoR) interacts with p-p14(ARF) (p14(ARF) promoter).-Pubmed
HPRDChromodomain helicase DNA binding protein 1nuclear receptor co-repressor 1--Pubmed

Recent Publications on NCOR1:

Pubmed Logo
Nuclear receptor co-repressor is required to maintain proliferation of normal intestinal epithelial cells in culture and down-modulates the expression of pigment epithelium-derived factor.
Stem cells of the gut epithelium constantly produce precursors that...
3rd November, 2009
Departement d'Anatomie et Biologie Cellulaire, Faculte de Medecine et des J Biol Chem. 2009 Sep 11;284(37):25220-9. Epub 2009 Jul 16.
DOI Direct Link
Retinoic acid mediates long-paced oscillations in retinoid receptor activity: evidence for a potential role for RIP140.
BACKGROUND: Mechanisms that underlie oscillatory transcriptional activity...
29th October, 2009
Department of Pharmacology and Toxicology, Hanover, New Hampshire, USA. PLoS One. 2009 Oct 28;4(10):e7639.
DOI Direct Link
Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling.
The human hyaluronan synthase 2 (HAS2) gene encodes for an enzyme making...
29th October, 2009
Department of Bioscience, of Kuopio, FIN-70211 Kuopio, Finland. J Biol Chem. 2009 Jul 3;284(27):18270-81. Epub 2009 May 5.
DOI Direct Link
Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene.
As a partner of cyclin-dependent kinase (CDK) 3, Cyclin C controls...
21st October, 2009
Department of Biosciences, University of Kuopio, Finland. J Mol Biol. 2009 Oct 23;393(2):261-71. Epub 2009 Aug 14.
DOI Direct Link
Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse.
BACKGROUND: Estrogen receptor alpha (ER alpha) is the most important...
29th September, 2009
Department of Breast and Endocrine Surgery, Faculty of Medical and Chin Med J (Engl). 2009 Aug 5;122(15):1764-8.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598080 Diagnostic assay for source of inflammation
7250496 Bioinformatically detectable group of novel regulatory genes and uses thereof
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7125660 Nucleic acid sensor molecules and methods of using same
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

NCOR1 results (if any) from reagent suppliers

Google CSE Logo
NCOR1 Antibody (N-term)
#AP1121a) is used in Western blot to detect NCOR1 in mouse thymus tissue lysate. NCOR1 Antibody (N-term). Formalin-fixed and paraffin-embedded human cancer ...
http://www.abgent.com/products/catalog_no/AP1121a_NCOR1_Anti...

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BIOMOL International - HDAC3/NCOR1 Complex (human, recombinant)
Produced by coexpression of HDAC3 with a GST-NCOR1(DAD) construct in an insect cell system, the complex displays ~100-fold higher deacetylase activity than ...
http://www.biomol.com/?pageId=38&categoryId=225&productId=35...

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NCOR1 Antibody (C-term)
Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein
kinases ...
http://www.abgent.com/products/catalog_no/AP1121b_NCOR1_Anti...

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HDAC3/NCOR1 Complex (human, recombinant) CATALOG NO.: BML-SE515 ...
3) Add 5 µl of diluted HDAC3/NCOR1 Complex (BML-SE515, 5 ng/µl) to the wells for the 0 min, 30 min, and 30 min. plus trichostatin ...
http://www.biomol.com/SiteData/docs/ProductData/SE515.pdf...

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Protein Modification / Acetylation - Protein Modification Antibody
AP1121a, NCOR1 Antibody (N-term), WB, IHC, E, H, M. AT2997a, NDST3 monoclonal antibody (M01), ELISA,S-ELISA,WB-Ce,WB-Re, H. AP1925a, NOC2L Antibody (Center)
...
http://www.abgent.com/products/category/protein_modification...

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N-CoR (H-303) Antibody sc-8994
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, NCOR1, 9611, 17p12, NM_006311 ...
http://www.scbt.com/datasheet-8994-n-cor-h-303-antibody.html...

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Abgent Antibodies and Peptides
AP1121a, NCOR1 Antibody (N-term), O75376 · AP1109a, HDAC9 Antibody (N-term), Q9UKV0 · AM7099a, PARK8 (LRRK2) Antibody, Q5S007 ...
http://www.abgent.com/docs/abgent_newsletter_2007_jan...

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