|
| |
NCOR2
| Symbol: | NCOR2 | | Name(s): | nuclear receptor co-repressor 2 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CTG26, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC-1, TRAC1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
|
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15635693 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16453284 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17991421 |
These results would shed new insights for the molecular mechanisms of PML-RARalpha-associated leukemogenesis. |
| 15802375 |
N-CoR and SMRT play an active role in preventing tamoxifen from stimulating proliferation in breast cancer cells through repression of a subset of target genes involved in ERalpha function and cell proliferation |
| 16373395 |
SMRT and N-CoR corepressors are involved in transcriptional regulation by both agonist- and antagonist-bound AR and regulate the magnitude of hormone response, at least in part, by competing with coactivators. |
| 15635693 |
No significant allelic/genotypic association between any of the five mutations in SMRT/N-CoR2 and bipolar phenotype and the CAG repeat did not demonstrate allelic instability. |
| 12388540 |
SMRT has a role as a coactivator for thyroid hormone receptor T3Ralpha from a negative hormone response element |
| 12840002 |
SANT motif interprets the histone code and promotes histone deacetylation |
| 12139968 |
The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression. |
| 17383980 |
expression of the silencing mediator of retinoid and thyroid receptor (SMRT) & histone deacetylase4 (HDAC4) enhances formation of Bach2 foci in nuclear matrix. SMRT mediates HDAC4 binding to Bach2, & HDAC4 facilitates retention of Bach2 in the foci. | →View more information from publications. |
Recent Publications on NCOR2: |  |
Loss of the SMRT/NCoR2 corepressor correlates with JAG2 overexpression in multiple myeloma.
Multiple myeloma (MM) is a clonal B-cell neoplasm that accounts for 10% of... | 9th July, 2009
| Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY
| Cancer Res. 2009 May 15;69(10):4380-7. Epub 2009 May 5.
DOI Direct Link |
Relaxin signaling in uterine fibroids.
Uterine fibroid is the most common tumor of female reproductive organs.... | 23rd May, 2009
| Department of Obstetrics and Gynecology, Baylor College of Medicine,
| Ann N Y Acad Sci. 2009 Apr;1160:374-8.
DOI Direct Link |
Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.
BACKGROUND: Only a limited number of studies have performed comprehensive... | 21st February, 2009
| Department of Preventive Medicine, Keck School of Medicine, University of
| BMC Cancer. 2009 Jan 30;9:43.
DOI Direct Link |
Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis.
The progressive debilitation of motor functions in Parkinson's disease... | 27th January, 2009
| Department of Environmental and Radiological Health Sciences, Colorado
| Mol Pharmacol. 2009 Jan;75(1):35-43. Epub 2008 Oct 7.
DOI Direct Link |
The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome.
BACKGROUND: Advances in understanding the molecular basis of breast cancer... | 17th September, 2008
| Division of Pathology, School of Molecular Medical Sciences, Nottingham
| Breast Cancer Res Treat. 2008 Aug;110(3):427-37. Epub 2007 Sep 28.
DOI Direct Link |
→View more research publications. |
NCOR2 results (if any) from reagent suppliers | 
|
Search Bioportfolio and other Life Science Sites for NCOR2,
or search for NCOR2 on BioPortfolio's antibody search engine.
This page has been viewed 443 times
Recent Search Terms used to find this page: cancer Repressor | NCOR2 promoter | pubmed Loss of the SMRT NCoR2 Corepressor Correlates with JAG2 Overexpression in Multiple Myeloma | mouse NCoR2 chip antibody | thyroid cancer repressor | nuclear receptor co-receptor 2 cancer | ncor2 retinoic acid | bach2 and ikk | Bach2 and multiple myeloma | .
Resources from the NCBI used on this page, NCBI's standard disclaimer applies.
|
