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ABCG1


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Symbol:ABCG1
Name(s):ATP-binding cassette, sub-family G (WHITE), member 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:ABC8, MGC34313, WHITE1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17187964 Observational study of gene-disease association. (HuGE Navigator)
17387528 Observational study of gene-disease association. (HuGE Navigator)
17761632 These results suggest that the ABCG1-mediated efflux of cholesterol and sphingomyelin (SM) is dependent on the cellular SM level and distribution of cholesterol in the plasma membrane.
15492319 ABCG1 is not required for apolipoprotein A-1-mediated endothelial cholesterol efflux from vascular endothelial cells.
15994327 ABCG1 redistributes cholesterol to cell-surface domains where it becomes accessible for removal by HDL, demonstrating its direct role of ABCG1 in cellular cholesterol transport
16902247 ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles
16357317 synergistic relationship between ABCA1 and ABCG1 in peripheral tissues, where ABCA1 lipidates any lipid-poor/free apoA-I to generate nascent or pre-beta-HDL
17121837 ABCG1 plays a significant role in the regulation of neuronal cholesterol efflux to apolipoprotein E discs.
17293612 altered cholesterol metabolism and amyloid precursor protein trafficking mediated by ABCG1 may contribute to the accelerated onset of Alzheimer's disease neuropathology in Down syndrome
15584507 Analysis of the effect of the Su(Hw) insulator on the expression of the miniwhite gene in Drosophila melanogaster.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDATP-binding cassette sub-family G member 1 isoform 1ATP-binding cassette, subfamily G, member 4--Pubmed

Recent Publications on ABCG1:

Pubmed Logo
Small Discoidal Pre-beta1 HDL Particles Are Efficient Acceptors of Cell Cholesterol via ABCA1 and ABCG1.
The aim of this study was to correlate the lipid content and size of...
21st October, 2009
Department of Pharmacological and Biological Sciences, and Applied Biochemistry. 2009 Oct 29.
DOI Direct Link
Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.
The losartan metabolite EXP3174 exhibits angiotensin II receptor 1...
21st October, 2009
Center for Cardiovascular Research, Institute of Pharmacology, Hypertension. 2009 Oct;54(4):738-43. Epub 2009 Aug 17.
DOI Direct Link
[The research progress of ATP binding cassette transporter G1]
ATP binding cassette transporter G1 (ABCG1) is a membrane half-transporter...
7th October, 2009
Institute of Cardiovascular Disease, University of South China, Hengyang Sheng Li Ke Xue Jin Zhan. 2009 Jul;40(3):229-33.
Role of HDL, ABCA1, and ABCG1 Transporters in Cholesterol Efflux and Immune Responses.
Atherosclerosis has been characterized as a chronic inflammatory response...
3rd October, 2009
Division of Molecular Medicine, Department of Medicine, Columbia Arterioscler Thromb Vasc Biol. 2009 Oct 1.
DOI Direct Link
The conjugated linoleic acid isomer trans-9,trans-11 is a dietary occurring agonist of liver X receptor alpha.
Conjugated linoleic acid (CLA) isomers are dietary fatty acids that...
2nd October, 2009
Institute of Clinical Chemistry, University of Regensburg, Germany. Biochem Biophys Res Commun. 2009 Oct 30;388(4):660-6. Epub 2009 Aug 13.
DOI Direct Link

View more research publications.

Press Releases on ABCG1:

BioPortfolio Logo
RVX-208 Data Demonstrates Increase in Functional HDL Particles 10th November, 2008 Resverlogix Corp.
    Prebeta-HDL generation and improved HDL functionality are distinguishing
    factors

    TSX Exchange Symbol: RVX

NEW ORLEANS, LA, Nov. 10 /PRNewswire-FirstCall/ -

Clinical Trials:

Clinical Trials Logo
Effects of Multiple Doses of CS-8080 in Healthy Volunteers

Patents:

Patents logo
US Patent No.Title
7592363 Indazoles
7341850 Human LXR.alpha. variants
7323494 Compounds and methods
7265131 Isoquinolinone derivatives and their use as therapeutic agents
7247748 Amide compounds and methods of using the same

View more patents.

ABCG1 results (if any) from reagent suppliers

Google CSE Logo
ABCG1 antibody (ab36969) | Abcam
Rabbit polyclonal to ABCG1. ABCG1, one of five members of the ABCG subfamily, belongs to the large family of ATP-binding cassette (ABC) transporters.
http://www.abcam.com/ABCG1-antibody-ab36969.html...

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Anti-ABCG1 Polyclonal Antibody
Polyclonal Antibody against ABCG1 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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ABCG1 (E-20) Antibody sc-11150
See how others have used ABCG1 (E-20): sc-11150 antibody and or ABCG1 (E-20) ... LXR-induced redistribution of ABCG1 to plasma membrane in macrophages ...
http://www.scbt.com/datasheet-11150-abcg1-e-20-antibody.html...

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ABCG1 antibodies: Cardiovascular > Lipids / Lipoproteins ...
ABCG1 antibodies. ... ABCG1 antibody (Biotin). IHC-P, WB. Rabbit polyclonal. Biotin conjugated. Reacts with: Hu, Ms. ab81954 · ABCG1 antibody (Hilyte Fluorâ„¢
...
http://www.abcam.com/index.html?t=148405&pt=1&c=866&ei=&mu=r...

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ABCG1 (E-20) Antibody sc-11150
LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances ... ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density
...
http://www.scbt.com/ko/datasheet-11150-abcg1-e-20-antibody.h...

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All Cell Type Marker | Abcam
ABCG1 antibody (Biotin). IHC-P, WB. Rabbit polyclonal. Biotin conjugated ... ABCG1 antibody (Hilyte Fluorâ„¢ 488). WB, ICC/IF. Rabbit polyclonal ...
http://www.abcam.com/index.html?c=414...

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ABC Antibody / ABC Antibodies
ABCG1 (E-20) Antibody, sc-11150, goat IgG, N-terminus (h), WB, IP, IF, ... ABCG1 (L-18) Antibody, sc-21808, goat IgG, C-terminal (h), WB, IF, ELISA, m, r, h ...
http://www.scbt.com/table-abc.html...

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