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KLK4
| Symbol: | KLK4 | | Name(s): | kallikrein-related peptidase 4 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ARM1, EMSP, EMSP1, KLK-L1, MGC116827, MGC116828, PRSS17, PSTS | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15059887 |
KLK4 has a unique structure and function compared with other members of the KLK family and may have a role in the biology and characterization of prostate cancer. |
| 16800736 |
an investigation of its enzymatic properties regarding substrate preference, degradation of extracellular matrix proteins, and its inhibition by various inhibitors |
| 16172196 |
Human kallikrein 4, in particular, and prostate specific antigen, have a functional role in the progression of prostate cancer through their promotion of tumour cell migration. |
| 12077288 |
The demonstration that KLK4-specific CD4 T cells exist in the peripheral circulation of normal male donors supports the use of KLK4 in whole gene-, protein-, or peptide-based vaccine strategies against prostate cancer. |
| 17221837 |
hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in prostate cancer bone metastasis |
| 16322328 |
There are two major isoforms of hK4 (KLK4-254/hK4-254 and KLK4-205/hK4-205) expressed in prostate cancer with different regulatory and expression profiles that imply both secreted and novel nuclear roles. |
| 17545602 |
KLK4 protein is significantly overexpressed in malignant prostate compared with normal prostate. KLK4 expression is predominantly in the nucleus of basal cells in the prostate epithelium in keeping with its distribution in prostate cancer cells in vitro. |
| 15235027 |
A novel human kallikrein mutation associated with a rare autosomal recessive form of amelogenesis imperfecta. |
| 16704423 |
Design of serpin fragments as highly specific inhibitors of human kallikrein 14. |
| 16497155 |
Here we demonstrate uPAR is a target for tissue kallikrein 4[hK4], cleaved in the D1-D2 linker and D3 domain. hK4 may modulate tumor-associated uPA/uPAR activity by activating the pro-enzyme form of uPA or cleaving the cell surface-associated uPA receptor | →View more information from publications. |
Recent Publications on KLK4: |  |
Mmp-20 and Klk4 cleavage site preferences for amelogenin sequences.
Mmp-20 and Klk4 are the two key enamel proteases. Can both enzymes process... | 9th October, 2009
| Department of Biologic and Materials Sciences, University of Michigan
| J Dent Res. 2009 Sep;88(9):823-8.
DOI Direct Link |
Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1.
In prostate cancer, the mechanism by which the stromal cells surrounding... | 2nd October, 2009
| Departments of Biochemistry University of Washington, Seattle, Washington.
| Int J Cancer. 2009 Sep 30.
DOI Direct Link |
Exclusion of candidate genes in seven Turkish families with autosomal recessive amelogenesis imperfecta.
Amelogenesis imperfectas (AI) are a group of inherited defects of dental... | 24th September, 2009
| Department of Periodontology, School of Dentistry, Ege University, Izmir,
| Am J Med Genet A. 2009 Jul;149A(7):1392-8.
DOI Direct Link |
Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women.
OBJECTIVES: This study was conducted to investigate the role of common... | 16th September, 2009
| Department of Preventive Medicine, Seoul National University College of
| Carcinogenesis. 2009 Sep;30(9):1528-31. Epub 2009 Apr 16.
DOI Direct Link |
Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4.
Human kallikrein-related peptidase 4 (KLK4/prostase), a trypsin-like... | 11th September, 2009
| Institute of Health and Biomedical Innovation, Queensland University of
| Chem Biol. 2009 Jun 26;16(6):633-43.
DOI Direct Link |
→View more research publications. |
KLK4 results (if any) from reagent suppliers | 
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KLK4 Antibody Anti-KLK4
This antibody recognizes the gene product hk4 of human KLK4 (also known as KLK- L1), one of the many kallikrein serine proteases associated with ...
http://www.prosci-inc.com/shop/catalog1/KLK4-Antibody-p-1542...
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KLK4 (LX-04) Antibody sc-80146
mouse monoclonal IgG2b, 100µg/ml; raised against KLK4 of human origin, with epitope mapping to amino acids 27-254; recommended for detection of KLK4 of ...
http://www.scbt.com/datasheet-80146-klk4-lx-04-antibody.html...
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KLK4 56237
242-254 of human KLK4 protein. Host Species: Rabbit. Antibody Class: Polyclonal ... product hk4 of human KLK4 (also known as KLK-L1), one of the many ...
http://www.qedbio.com/v/pdf/56237.pdf...
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KLK Antibody / KLK Antibodies
KLK4 (LX-04) Antibody, sc-80146, mouse IgG2b, 27-254 (h), WB, IP, human. KLK4 (S -15) Antibody, sc-20373, goat IgG, internal (h), WB, IF, ELISA, human ...
http://www.scbt.com/table-klk.html...
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Antibodies to Proteins of Inflammation
K3014, Anti-Kallikrein L1 (KLK-L1, KLK4) antibody produced in rabbit, ( polyclonal), affinity isolated antibody, human ... KLK4(9622) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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KLK4 (N-14) Antibody sc-20371
KLK4 (N-14) 抗体sc-20371 KLK4 (N-14) Antibody sc-20371.
http://www.scbt.com/zh/datasheet-20371-klk4-n-14-antibody.ht...
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Abgent Antibodies and Peptides
AP6334b, KLK15 Antibody (Center V146), H. AP6321b, KLK2 Antibody (C-term), H. AP6321a, KLK2 Antibody (N-term), H. AP6323b, KLK4 Antibody (C-term), H ...
http://www.abgent.com/docs/product_investigation...
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