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CD59
| Symbol: | CD59 | | Name(s): | CD59 molecule, complement regulatory protein | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | 16.3A5, EJ16, EJ30, EL32, G344, MGC2354, MIC11, MIN1, MIN2, MIN3, MSK21, PROTECTIN, p18-20 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17644516 |
the amount of C5b-9-AF488 bound to K562 cells after complement activation was highly heterogeneous and inversely correlated with the CD59 level of expression |
| 17671359 |
Electron-density map of recombinant CD59 crystals shows an as yet unidentified small molecule in the predicted C8/C9-binding site. |
| 17635812 |
Essential for the protection of neurons in the NT2-N teratocarcinoma cell line against complement attack. |
| 17585877 |
These results suggest that IRE1alpha-mediated mRNA cleavage functions even in mammals as a common system to regulate gene expression. |
| 16493049 |
CD59 on target cells enhances the cytotoxicity of natural killer cells, an effect dependent on the glycosylphosphatidylinositol anchor in CD59. |
| 17505110 |
When compared with previous models of CD59 determined using NMR, some interesting differences are noted, including the position of helix alpha1, which contributes to the binding surface for C8 and C9. |
| 15448097 |
Glycation inactivation of hCD59 leads to increased membrane attack complex deposition may contribute to the extensive vascular pathology that complicates human diabetes. |
| 15543155 |
Streptococcus intermedius intermedilysin specifically binds to huCD59 via residues that are the binding site for the C8alpha and C9 complement proteins |
| 16859540 |
Upregulation of CD59 and decay-accelerating factor by atorvastatin in hypoxia prevented deposition of C3, C9 and cell lysis that follows exposure of reoxygenated vascular endothelial cells to serum. |
| 14635045 |
CD59 is physically associated with NKp46 and NKp30 and activate human nk cell-mediated cytotoxicity. | →View more information from publications. |
Recent Publications on CD59: |  |
Early expression changes of complement regulatory proteins (CRegs) and C5a receptor (CD88) on leukocytes after multiple injury in humans.
As a crucial element of innate immunity, the complement cascade becomes... | 30th October, 2009
| 1Department of Traumatology, Hand-, Plastic- and Reconstructive Surgery
| Shock. 2009 Oct 27.
DOI Direct Link |
Reduction of Neu5GC Xenoantigen on Human ADSC/MSCs lead to Them as Safer and More Useful Cell Sources for Realizing Various Stem Cell Therapies.
Adipose tissue is an attractive source for somatic stem cell therapy.... | 30th October, 2009
| Foundation of Biomedical Research and Innovation, Department of Somatic
| Tissue Eng Part A. 2009 Oct 28.
DOI Direct Link |
Clinical significance of complement deficiencies.
The complement system is composed of more than 30 serum and membrane-bound... | 30th October, 2009
| Division of Rheumatology, Allergy and Clinical Immunology, University of
| Ann N Y Acad Sci. 2009 Sep;1173:108-23.
DOI Direct Link |
[Clone, prokaryotic expression and pre-paration of polyclonal antibody of hCD59.]
AIM: To construct full length hCD59 eukaryotic and extracellular domain of... | 9th October, 2009
| Department of Immunology, State Key Laboratory of Virology, Wuhan
| Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Oct;25(10):924-6.
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Hepatitis B virus sensitizes hepatocytes to complement-dependent cytotoxicity through downregulating CD59.
Hepatitis B virus (HBV) infection afflicts over 350 million people... | 7th October, 2009
| Department of Immunology, Shandong University School of Medicine, Jinan
| Mol Immunol. 2009 Oct 3.
DOI Direct Link |
→View more research publications. |
Press Releases on CD59:
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| ARIUS announces second quarter fiscal 2008 financial results |
11th July, 2008 |
ARIUS Research Inc. |
TORONTO, July 11 /PRNewswire-FirstCall/ - ARIUS Research Inc., (TSX: ARI),
a biotechnology company discovering and developing the next wave of antibody
therapeutics, today announced its
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CD59 results (if any) from reagent suppliers | 
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CD59 Antibody / CD59 Antibodies
CD59 Antibody / CD59 Antibodies. ... CD59 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-cd59.html...
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The Abcam catalog
CD59 antibodies. ... CD59 antibody [1B4]. Flow Cyt, WB, IP. Mouse monoclonal ... CD59 antibody [MEM-129] - Azide free. Flow Cyt. Mouse monoclonal ...
http://www.abcam.com/index.html?t=7306&pt=1&c=3568...
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CD59 Monoclonal Antibody CD59 Glycoprotein
Left: Immunohistochemistry staining of CD59 in skin, sweat glands formlin-fixed paraffin-embedded) using CD59 monoclonal antibody. ...
http://www.prosci-inc.com/shop/catalog1/CD59-Monoclonal-Anti...
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FITC Anti-human CD59 Antibody Anti-CD59 - BioLegend
FITC Anti-human CD59 Antibody Anti-CD59 - CD59 is a 19-25 kD glycosylphosphatidylinositol (GPI)-anchored glycoprotein also known as protectin
, MACIF, ...
http://www.biolegend.com/fitc-anti-human-cd59-antibody-888.h...
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CD59 antibody [MEM-43] (ab9182) | Abcam
Mouse monoclonal [MEM-43] to CD59. CD59, an LY6 like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack ...
http://www.abcam.com/CD59-antibody-MEM-43-ab9182.html...
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CD59 (C-19) Antibody sc-7076
See how others have used CD59 (C-19): sc-7076 antibody and or CD59 (C-19) antibody ... Cooperation between human DAF and CD59 in protecting cells from
human ...
http://www.scbt.com/datasheet-7076-cd59-c-19-antibody.html...
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Monoclonal Antibody to CD59 PE-Dyomics 647 (PE-DY647) conjugated ...
The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 ( Protectin) .... antibody epitopes of the complement-inhibitory glycoprotein,
CD59. ...
http://www.exbio.cz/pdf/data_sheet_new.py/CLO000000000000055...
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