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JMJD2A


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Symbol:JMJD2A
Name(s):jumonji domain containing 2A
Type:protein-coding
Organism:Homo sapiens
Synonyms:JHDM3A, JMJD2, KDM4A, KIAA0677
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18084306 JMJD2A has the unique property of binding trimethylated peptides from two different histone sequences.
17611647 Human JMJD2A was expressed in undifferentiated and differentiated ES cells.
17589523 Crystal structures of the JMJD2A catalytic domain in complex with H3K9me3, H3K36me2 and H3K36me3 peptides are presented.
17589501 how human JMJD2A, which is selective towards tri- and dimethylated histone H3 lysyl residues 9 and 36 (H3K9me3/me2 and H3K36me3/me2), discriminates between methylation states and achieves sequence selectivity for H3K9
16732292 JHDM3A may function in euchromatin to remove histone methylation marks that are associated with active transcription
17555712 identified two related histone demethylases, JMJD2A and JMJD2D
16024779 JMJD2A selectively represses the expression of the achaete scute-like homologue 2 (ASCL2) gene but not other imprinted genes in the same imprinted locus in HeLa cells
16601153 crystal structure of the double tudor domain of JMJD2A both in the presence and absence of a trimethylated H3-K4 peptide
15927959 The ability of JMJD2A to associate with retinoblastoma proteins and histone deacetylase 1 implies an important role for this protein in cell proliferation and oncogenesis.

Recent Publications on JMJD2A:

Pubmed Logo
Protein phosphatase 1 regulates the histone code for long-term memory.
Chromatin remodeling through histone posttranslational modifications...
31st October, 2009
Brain Research Institute, University of Zurich, Swiss Federal Institute of J Neurosci. 2009 Oct 14;29(41):13079-89.
DOI Direct Link
Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II).
JMJD2A, a 2-oxoglutarate dependent N(epsilon)-methyl lysine histone...
21st October, 2009
Department of Chemistry and the Oxford Centre for Integrative Systems Chem Commun (Camb). 2009 Nov 14;(42):6376-8. Epub 2009 Sep 28.
DOI Direct Link
Identification of non-histone substrates for JMJD2A-C histone demethylases.
Recent studies have shown that some Jumonji domain containing proteins...
6th October, 2009
Division of Pharmaceutical Sciences, School of Pharmacy, University of Biochem Biophys Res Commun. 2009 Dec 11;390(2):280-4. Epub 2009 Sep 30.
DOI Direct Link
The histone demethylase DmelKdm4A controls genes required for life span and male-specific sex determination in Drosophila.
Histone methylation plays an important role in regulating...
30th September, 2009
Department of Biology, Drexel University. Philadelphia, PA 19104, USA. Gene. 2009 Sep 25.
DOI Direct Link
Identification and characterization of posttranslational modification-specific binding proteins in vivo by mammalian tethered catalysis.
Increasing evidence indicates that an important consequence of protein...
27th August, 2009
Department of Biochemistry and Molecular Biology, University of Southern Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14808-13. Epub 2009 Aug 18.
DOI Direct Link

View more research publications.

JMJD2A results (if any) from reagent suppliers

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JMJD2A Antibody Bethyl Laboratories
JMJD2A is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences ...
http://www.bethyl.com/go/?product/A300-861A/TreeKey=f6f398b3...

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KDM4A / JHDM3A / JMJD2A antibody - ChIP Grade (ab24545) | Abcam
Rabbit polyclonal to KDM4A / JHDM3A / JMJD2A - ChIP Grade. The JHDM3A/JMJD2A gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein
...
http://www.abcam.com/KDM4A-JHDM3A-JMJD2A-antibody-ChIP-Grade...

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JMJD2A Antibody (N-term)
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the JMJD2A gene (Lane 2) (Origene Technologies). ...
http://www.abgent.com/products/catalog_no/AP1046a_JMJD2A_Ant...

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JMJD2A (C70G6) Rabbit mAb #3393
JMJD2A (C70G6) Rabbit mAb detects endogenous levels of total JMJD2A protein. This antibody does not cross-react with other Jumonji C proteins, ...
http://www.cellsignal.com/products/3393.html...

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KDM4A / JHDM3A / JMJD2A antibodies: Chromatin and Nuclear ...
KDM4A / JHDM3A / JMJD2A antibodies. ... Image Abreview Publication. ab70785 · KDM4A / JHDM3A / JMJD2A antibody. IP. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=124721&pt=1&c=4168&ei=&mu=...

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JMJD2A (C70G6) Rabbit mAb
detects endogenous levels of total JMJD2A protein. This an- tibody does not cross-react with other ... coupled) corresponding to the human JMJD2A protein.
...
http://www.cellsignal.com/pdf/3393.pdf...

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JMJD Antibody / JMJD Antibodies
JMJD2A (3559D5a) Antibody, sc-81302, mouse IgG2a, Internal (h), WB, IP, human. JMJD2A (T-18) Antibody, sc-54624, goat IgG, Internal (h), WB, IP, IF, ELISA ...
http://www.scbt.com/table-jmjd.html...

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