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MELK
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17722061 |
a critical role for MELK in the proliferation of brain tumors, including their stem cells, and suggest that MELK may be a compelling molecular target for treatment of high-grade brain tumors. |
| 17960622 |
Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in astrocytomas |
| 17280616 |
the kinase activity of MELK is likely to affect mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL |
| 16216881 |
analysis of MELK substrate specificity and activity regulation |
| 12400006 |
pEg3 is a potential regulator of the G2/M progression and may act antagonistically to the CDC25B phosphatase,pEg3 kinase is able to specifically phosphorylate CDC25B in vitro. One phosphorylation site was identified and corresponded to serine 323 |
Recent Publications on MELK: |  |
Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.
INTRODUCTION : Programmed cell death through apoptosis plays an essential... | 13th August, 2009
| Institute for Science and Technology in Medicine and School of Life
| Breast Cancer Res. 2009;11(4):R60. Epub 2009 Aug 11.
DOI Direct Link |
Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone.
Current therapies for glioblastoma (GBM) target bulk tumor through... | 6th August, 2009
| University of California Los Angeles, Los Angeles, CA, 90095, USA.
| J Neurooncol. 2009 Aug 5.
DOI Direct Link |
Methods for analysis of brain tumor stem cell and neural stem cell self-renewal.
Neural stem cells (NSC) self-renew and are multipotent, producing neurons... | 8th July, 2009
| Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los
| Methods Mol Biol. 2009;568:37-56.
DOI Direct Link |
Ageing mouse kidney--not always the SAME old story.
BACKGROUND: As interest in the ageing kidney grows rapidly, more... | 29th May, 2009
| Department of Nephrology, Hannover Medical School, Hannover, Germany.
| Nephrol Dial Transplant. 2009 Oct;24(10):3002-5. Epub 2009 May 27.
DOI Direct Link |
Effects of donor age and cell senescence on kidney allograft survival.
The biological processes responsible for somatic cell senescence... | 31st March, 2009
| Division of Pediatric Nephrology, Gastroenterology and Metabolic Diseases,
| Am J Transplant. 2009 Jan;9(1):114-23.
DOI Direct Link |
→View more research publications. |
MELK results (if any) from reagent suppliers | 
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