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CDC25A
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18204780 |
These results suggest that CDC25A, by inhibiting hepatocellular carcinoma (HCC) growth and invasion, may be a feasible therapeutic target for human HCC. |
| 18167338 |
Glycogen synthase kinase-3beta (GSK-3beta) phosphorylates Cdc25A to promote its proteolysis in early cell-cycle phases. |
| 17912454 |
protein kinase CK2 is involved in cell cycle regulation and indicate the mechanism by which CDC25A turnover might be regulated by Chk1 in the absence of DNA damage. |
| 17545210 |
Arsenite slows S phase progression via inhibition of cdc25A dual specificity phosphatase gene transcription. |
| 17671423 |
hypoxia inhibits the expression of CDC25A, another cell cycle gene encoding a tyrosine phosphatase that maintains CDK2 activity |
| 15798217 |
Ubiquitination and degradation of CDC25A protein depend on the TGF-beta-Smad3 pathway. |
| 14603323 |
beta-TrCP has a crucial role in mediating the response to DNA damage through Cdc25A degradation |
| 16912045 |
the Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism |
| 12738732 |
Overexpression of CDC25A phosphatase is associated with hypergrowth activity of hepatocellular carcinomas |
| 12963847 |
regulation of human Cdc25A stability by its phosphorylation at S75 may contribute to S phase checkpoint activation | →View more information from publications. |
Recent Publications on CDC25A: |  |
Cell death induced by N-methyl-N-nitrosourea, a model S(N)1 methylating agent, in two lung cancer cell lines of human origin.
New therapeutic approaches are needed for lung cancer, the leading cause... | 22nd October, 2009
| Institute of Biological Research and Biotechnology, National Hellenic
| Apoptosis. 2009 Sep;14(9):1121-33.
DOI Direct Link |
Interaction between HMGA1 and retinoblastoma protein is required for adipocyte differentiation.
It is generally accepted that the regulation of adipogenesis prevents... | 20th October, 2009
| Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio
| J Biol Chem. 2009 Sep 18;284(38):25993-6004. Epub 2009 Jul 26.
DOI Direct Link |
miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.
The Rb-E2F pathway drives cell cycle progression and cell proliferation,... | 17th October, 2009
| Cancer Biology and Pharmacology, Genome Institute of Singapore, A*STAR
| Genes Dev. 2009 Oct 15;23(20):2388-93.
DOI Direct Link |
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.
microRNAs (miRNA) are small noncoding RNAs that participate in diverse... | 15th October, 2009
| Departments of Pathology and Pharmacology, University of Pittsburgh Cancer
| Cancer Res. 2009 Oct 15;69(20):8157-65. Epub 2009 Oct 13.
DOI Direct Link |
Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.
Triptolide, a natural product extracted from the Chinese plant... | 8th October, 2009
| Centre de Recherche en Oncologie Experimentale, Institut de Recherche
| Mol Cancer Ther. 2009 Oct;8(10):2780-90. Epub 2009 Oct 6.
DOI Direct Link |
→View more research publications. |
CDC25A results (if any) from reagent suppliers | 
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