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Huntington's disease is a hereditary disease caused by a defect in a single gene on Chromosome 4 that is inherited in an autosomal dominant fashion. The defect causes a part of DNA, called a CAG repeat, to occur many more times than it is supposed to; normally, this section of DNA is repeated 10 to 35 times, but in persons with Huntington's disease, it is repeated 36 to 120 times.
Symptoms begin in early middle age and include an unsteady gait, jerky involuntary movements with later behavioral changes and progressive <!--LGfEGNT2Lhm-->dementia. There are two forms of Huntington's disease; adult-onset Huntington's disease (symptom onset in the mid 30's and 40's) and early-onset Huntington's disease (begins in childhood or adolescence). Genetic testing is available to test for the condition.
There is no cure for Huntington's disease, and there is no known way to stop the disease from getting worse. Currently, dopamine blockers are used to help reduce the movement disorders, but there is great demand for more effective treatments.
Source; adapted from NIH
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