Acatalasia

Acatalasia is an autosomal recessive peroxisomal disorder caused by a complete lack of catalase. The disorder is relatively benign, although it causes an increased incidence of periodontal infections, and can under rare circumstances lead to gangrene. (From the Wikpedia article Acatalasia.)

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Recent Publications on Acatalasia:
Drug delivery to peroxisomes: employing unique trafficking mechanisms to target protein therapeutics. Peroxisomes are multifunctional organelles of all human cells, responsible...	21st December, 2007	Department of Pharmacology, Wayne State University School of Medicine, 540	Adv Drug Deliv Rev. 2007 Aug 10;59(8):739-47. Epub 2007 Jun 28. DOI Direct Link
Catalase deficiency may complicate urate oxidase (rasburicase) therapy. Patients with low (inherited and acquired) catalase activities who are...	6th December, 2007	Department of Clinical Biochemistry, Molecular Pathology and Clinical	Free Radic Res. 2007 Sep;41(9):953-5. DOI Direct Link
Peroxisomes and aging. Peroxisomes are indispensable for proper functioning of human cells. They...	24th March, 2007	Department of Pharmacology, Wayne State University School of Medicine, 540	Biochim Biophys Acta. 2006 Dec;1763(12):1749-54. Epub 2006 Aug 23. DOI Direct Link
Mammalian catalase: a venerable enzyme with new mysteries. Mammalian catalase has been the subject of many classic biochemical...	17th March, 2007	Department of Pediatrics, Division of Genetics and Metabolism, University	Trends Biochem Sci. 2007 Jan;32(1):44-50. Epub 2006 Dec 8. DOI Direct Link
Effects of post low-dose X-ray irradiation on carbon tetrachloride-induced acatalasemic mice liver damage. The catalase activities in the blood and organs of the acatalasemic...	2nd November, 2006	Okayama University Medical School, Japan.	Physiol Chem Phys Med NMR. 2005;37(2):109-26.
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Acatalasia Patents:
US Patent No.	Title
7359748	Apparatus for total immersion photography
4749570	Targeting conjugates of albumin and therapeutic agents

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