Acidosis

:For acidosis referring to acidity of the urine, see renal tubular acidosis.Acidosis is an increased acidity . If not further qualified, it refers to acidity of the blood plasma. Acidosis is said to occur when arterial pH falls below 7.35, while its counterpart occurs at a pH over 7.45. Arterial blood gas analysis and other tests are required to separate the main causes.The term acidemia describes the state of low blood pH, while acidosis is used to describe the processes leading to these states. Nevertheless, physicians sometimes use the terms interchangeably. The distinction may be relevant where a patient has factors causing both acidosis and alkalosis, where the relative severity of both determines whether the result is a high or a low pH.The rate of cellular metabolic activity affects and, at the same time, is affected by the pH of the body fluids. In mammals, the normal pH of arterial blood lies between 7.35 and 7.50 depending on the species . Blood pH values compatible with life in mammals are limited to a pH range between 6.8 and 7.8. Changes in the pH of arterial blood outside this range result in irreversible cell damage . (From the Wikpedia article Acidosis.)

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Recent Publications on Acidosis:
Hypercapnic acidosis attenuates the pulmonary innate immune response in ventilated healthy mice. BACKGROUND:: Mechanical ventilation with small tidal volumes reduces the...	4th July, 2008	From the Maxima Medical Centre (FJH), Veldhoven, Netherlands; Departments	Crit Care Med. 2008 Jul 1;. DOI Direct Link
Fusobacterium necrophorum: A ruminal bacterium that invades liver to cause abscesses in cattle. Fusobacterium necrophorum, a Gram-negative, rod-shaped, and an...	4th July, 2008	Department of Diagnostic Medicine/Pathobiology, College of Veterinary	Anaerobe. 2008 May 24;. DOI Direct Link
Modified Mainz pouch II (Sigma Rectum pouch) urinary diversion: 12 years experience. OBJECTIVE: To analyze the outcome of Mainz Pouch II urinary diversion...	4th July, 2008	Urological Clinic, Clinical Center Nis, Serbia.	Acta Chir Iugosl. 2007;54(4):73-7.
Urinary diversion: 30 years experience of a single centre in Republic of Macedonia. OBJECTIVES: The aim of this report is to present our 30 years experience...	4th July, 2008	Clinic of Urology-Skopje, Skopje, Macedonia.	Acta Chir Iugosl. 2007;54(4):49-55.
The history of urinary diversion. The earliest attempt to divert urine flow from the ureters to the...	4th July, 2008	Urological Clinic, Clinical Center Nis, Serbia.	Acta Chir Iugosl. 2007;54(4):9-17.
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BioNews Results for Acidosis:
Long-Term Dichloroacetate for Lactic Acidosis Fairly Well Tolerated	Medscape:  May 29 2008 5:10AM Matching: acidosis

Acidosis Clinical Trials:
Basal Insulin in the Management of Patients With DKA	Diabetic Ketoacidosis
Fluid Shifts During Resuscitation: Impacts on Macrocirculation and Microcirculation
Effects of Nurse-Counselling in the Improvement of the type1 Diabetes Control in Adolescents	Type 1 Diabetes
Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-Pulmonary Bypass	Congenital Heart Surgery;   Cardiopulmonary Bypass
Sub-Cutaneous Insulin in Hyperglycaemic Emergencies	Diabetes Mellitus
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Acidosis Patents:
US Patent No.	Title
7365047	Use of pentagastrin to inhibit gastric acid secretion or as a diuretic
7375113	Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs
7375124	Use of .alpha.-phenylthiocarboxylic and .alpha.-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
7375133	Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease
7378056	Circuits for in vivo detection of biomolecule concentrations using fluorescent tags
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