Acidosis

:For acidosis referring to acidity of the urine, see renal tubular acidosis.Acidosis is an increased acidity . If not further qualified, it refers to acidity of the blood plasma. Acidosis is said to occur when arterial pH falls below 7.35, while its counterpart occurs at a pH over 7.45. Arterial blood gas analysis and other tests are required to separate the main causes.The term acidemia describes the state of low blood pH, while acidosis is used to describe the processes leading to these states. Nevertheless, physicians sometimes use the terms interchangeably. The distinction may be relevant where a patient has factors causing both acidosis and alkalosis, where the relative severity of both determines whether the result is a high or a low pH.The rate of cellular metabolic activity affects and, at the same time, is affected by the pH of the body fluids. In mammals, the normal pH of arterial blood lies between 7.35 and 7.50 depending on the species . Blood pH values compatible with life in mammals are limited to a pH range between 6.8 and 7.8. Changes in the pH of arterial blood outside this range result in irreversible cell damage . (From the Wikpedia article Acidosis.)

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Recent Publications on Acidosis:
PDH E(1)beta deficiency with novel mutations in two patients with Leigh syndrome. Most cases of pyruvate dehydrogenase complex (PDHc) deficiency are...	20th November, 2009	Institut de Bioquimica Clinica, Servei de Bioquimica i Genetica Molecular,	J Inherit Metab Dis. 2009 Nov 9. DOI Direct Link
Feeding barley grain steeped in lactic acid modulates rumen fermentation patterns and increases milk fat content in dairy cows. The objectives of the present in vivo and in situ trials were to evaluate...	20th November, 2009	Department of Agricultural, Food and Nutritional Science, University of	J Dairy Sci. 2009 Dec;92(12):6023-6032. DOI Direct Link
Invited review: The use of distillers products in dairy cattle diets. Distillers grains with solubles (DGS) is the major coproduct of ethanol...	20th November, 2009	Dairy Science Department, South Dakota State University, Brookings	J Dairy Sci. 2009 Dec;92(12):5802-5813. DOI Direct Link
Severe hyponatremia occurring after surgical stress in a patient with mitochondrial disease. A 53-year-old man with mitochondrial disease underwent gastrectomy because...	19th November, 2009	Department of Anesthesia, Inabe General Hospital, 771 Ageki, Hokusei-cho,	J Anesth. 2009 Nov;23(4):587-590. Epub 2009 Nov 18. DOI Direct Link
Comparison of community-acquired pneumonia due to methicillin-resistant and methicillin-susceptible Staphylococcus aureus producing the Panton-Valentine leukocidin. OBJECTIVE: To investigate the clinical features and prognosis of patients...	19th November, 2009	Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece; Department	Int J Tuberc Lung Dis. 2009 Dec;13(12):1476-1485.
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BioNews Results for Acidosis:
Diabetes warning after teen's death	Southend Today:  Nov 19 2009 12:55PM Matching: acidosis
Lactic Acidosis Associated With Metformin in a Patient With Type 2 Diabetes With No Contraindication	MDLinx:  Nov 13 2009 11:14AM Matching: acidosis
Presented At CHEST 2009 - New Pediatric Lung Health Research	Medical News Today:  Nov 4 2009 8:21PM Matching: acidosis

Acidosis Clinical Trials:
Metabolic Acidosis in Renal Transplant Patients

Acidosis Patents:
US Patent No.	Title
7585880	Phenylpropanoic acid derivatives
7595333	Agent for improving acidosis
7597916	Livestock anti-acid composition
7598039	Treatment of insulin resistance
7598060	Rapid analysis of variations in a genome
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