Acromegaly

Acromegaly is a syndrome that results when the pituitary gland produces excess growth hormone after epiphyseal plate closure. A number of disorders may be affecting the pituitary to create this circumstance, although most commonly it involves a GH producing tumor derived from a distinct type of cells and called pituitary adenoma.Acromegaly most commonly affects adults in their early twenties, and can result in severe disfigurement, serious complicating conditions, and premature death if unchecked. Because of its insidious pathogenesis and slow progression, the disease is hard to diagnose in the early stages and is frequently missed for many years, when changes in external features, especially of the face, become noticeable.Acromegaly is often also associated with gigantism. (From the Wikpedia article Acromegaly.)

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Recent Publications on Acromegaly:
Pegvisomant: current and potential novel therapeutic applications. BACKGROUND: Pegvisomant is a genetically engineered molecule, which...	18th November, 2009	University of Cambridge, Department of Paediatrics, Cambridge, UK.	Expert Opin Biol Ther. 2009 Dec;9(12):1553-63. DOI Direct Link
Acromegaly pathogenesis and treatment. Dysregulated growth hormone (GH) hypersecretion is usually caused by a...	18th November, 2009	Department of Medicine, Cedars-Sinai Medical Center, Los Angeles,	J Clin Invest. 2009 Nov;119(11):3189-202. doi: 10.1172/JCI39375. Epub 2009 DOI Direct Link
Endovascular obliteration of an intracranial pseudoaneurysm: the utility of Onyx. Pseudoaneurysms are rare lesions with a multitude of causes, including...	18th November, 2009	Department of Neurological Surgery, University of Virginia Health System,	J Neurosurg Pediatr. 2009 Nov;4(5):445-8. DOI Direct Link
Aftercare in patients with Cushing's disease and acromegaly: is there room for improvement? PURPOSE: Evaluation of aftercare, medical therapy and remission rate for...	17th November, 2009	Department of Neurosurgery, University of Tuebingen, Hoppe-Seyler-Strasse	Acta Neurochir (Wien). 2009 Nov 13. DOI Direct Link
Increased plasma endothelin level as an endothelial marker of cardiovascular risk in patients with active acromegaly: A comparison with plasma homocysteine. The aim of the present study was to evaluate the plasma endothelin-1...	13th November, 2009	Clinical Center of Endocrinology, Medical University, Sofia, Bulgaria.	Methods Find Exp Clin Pharmacol. 2009 Sep;31(7):457-61. DOI Direct Link
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Press Releases About Acromegaly:
Reportlinker Adds Injectable Drug Delivery: Market Impact and Industry Trends	10th November, 2009	Reportlinker	-- Outlook for the injectable drug delivery technology Who should buy this report? -- Stakeholders in the injectable drug delivery market -- Companies interested in understanding

BioNews Results for Acromegaly:
Higher hydrocortisone dose may be associated with increased mortality in acromegaly	Endocrine Today:  Nov 12 2009 4:42PM Matching: acromegaly
Reportlinker Adds Injectable Drug Delivery: Market Impact and Industry Trends	Freshnews.com:  Nov 10 2009 4:54PM Matching: acromegaly

Acromegaly Clinical Trials:
Glucose Tolerance in Acromegaly: The Influence of GH-excess on Glucose Metabolism and Insulin Resistance

Acromegaly Patents:
US Patent No.	Title
7534595	Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
7558778	Semantic exploration and discovery
7560100	Mixtures of polypeptides, compositions containing and processes for preparing same, for treating neurodegenerative diseases
7560101	Method of treatment of an infection in an animal with GM-CSF cysteine muteins in the proximal region to helix A
7560102	Method for reducing neuronal degeneration so as to ameliorate the effects of injury or disease
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Companies working in the area of Acromegaly from Bioportfolio's Biocorporate database :
Company Name
Tercica Tercica, Inc., based in Brisbane, Calif., is a biopharmaceutical company committed to improving endocrine health. We are helping patients by partnering with the scientific and medical community to... www.tercica.com/        View full profile

BioPortfolio Ltd. offers e-mail and postal lists for Acromegaly scientists - we have details of around 722 individuals working on Acromegaly .