Acrosome

In spermatozoa of many animals, the Acrosome is an organelle that develops over the anterior half of the sperm's head. It is a cap-like structure derived from the Golgi apparatus. Acrosome formation is completed during testicular maturation. In Eutherian mammals the acrosome contains digestive enzymes . These enzymes breakdown the outer membrane of the ovum called the zona pellucida, allowing the haploid nuclei in the sperm to join with the haploid nucleus found in the ova. (From the Wikpedia article Acrosome.)

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Recent Publications on Acrosome:
USP8, a Regulator of Endosomal Sorting, Is Involved in Mouse Acrosome Biogenesis Through Interaction with the Spermatid ESCRT-0 Complex and Microtubules. USP8 is a deubiquitinating enzyme that works as a regulator of endosomal...	5th February, 2010		Biol Reprod. 2010 Feb 3. DOI Direct Link
Epididymal Hypo-Osmolality Induces Abnormal Sperm Morphology and Function in the Estrogen Receptor Alpha Knockout Mouse. Estrogen receptor-alpha (ESR1) is highly expressed in the efferent...	5th February, 2010		Biol Reprod. 2010 Feb 3. DOI Direct Link
The Cryoprotective Effects of Vitamin B(12) Supplementation on Bovine Semen Quality. Contents The present study aimed to investigate the effects of vitamin...	2nd February, 2010	College of Animal Science and Technology, Northwest A & F University,	Reprod Domest Anim. 2010 Jan 26. DOI Direct Link
Proteomic analysis of proteins involved in spermiogenesis in mouse. Spermiogenesis is a unique process in mammals during which haploid round...	27th January, 2010		J Proteome Res. 2010 Jan 25. DOI Direct Link
Delineation of downstream signalling components during acrosome reaction mediated by heat solubilized human zona pellucida. ABSTRACT: BACKGROUND: Human egg is enveloped by a glycoproteinaceous...	26th January, 2010		Reprod Biol Endocrinol. 2010 Jan 23;8(1):7. DOI Direct Link
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Acrosome Clinical Trials:
Human Sperm Binding to Transgenic Mouse Eggs

Acrosome Patents:
US Patent No.	Title
7208265	Method of cryopreserving selected sperm cells
7309699	3-Quinuclidinyl amino-substituted biaryl derivatives
7335507	Process for the staining of sperm
7339029	Sperm-specific cation channel, CatSper2, and uses therefor
7339090	Microinjection devices and methods of use
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BioPortfolio Ltd. offers e-mail and postal lists for Acrosome scientists - we have details of around 558 individuals working on Acrosome .