Saturday November 21 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

Adenoviridae

Adenoviruses are medium-sized , nonenveloped icosahedral viruses containing double-stranded DNA. There are over 51 different serotypes in humans, which are responsible for 5–10% of upper respiratory infections in children, and many infections in adults as well. Viruses of the family Adenoviridae infect various species of animals, including humans. Adenoviruses were first isolated in human adenoids , from which the name is derived, and are classified as group I under the Baltimore classification scheme. Adenoviruses represent the largest nonenveloped viruses, because they are the maximum size able to be transported through the endosome . The virion also has a unique "spike" or fibre associated with each penton base of the capsid that aids in attachment to the host cell via the coxsackie-adenovirus receptor on the surface of the host cell. There are 51 immunologically distinct human adenovirus serotypes that can cause human infections ranging from respiratory disease , and conjunctivitis , to gastroenteritis . Adenoviruses are unusually stable to chemical or physical agents and adverse pH conditions, allowing for prolonged survival outside of the body and water. Adenoviruses are primarily spread via respiratory droplets, however they can also be spread by fecal routes as well.Most infections with adenovirus result in infections of the upper respiratory tract. Adenovirus infections often show up as conjunctivitis, tonsilitis , an ear infection, or croup. Adenoviruses can also cause gastroenteritis . A combination of conjunctivitis and tonsilitis is particularly common with adenovirus infections. Some children can develop adenovirus bronchiolitis or pneumonia, both of which can be severe. In babies, adenoviruses can also cause coughing fits that look almost exactly like whooping cough. Adenoviruses can also cause viral meningitis or encephalitis. Rarely, adenovirus can cause cystitis .Most people recover from adenovirus infections by themselves, but people with immunodeficiency sometimes die of adenovirus infections, and—rarely—even previously healthy people can die of these infections.Adenoviruses are often transmitted by coughed-out droplets, but can also be transmitted by contact with an infected person, or by virus particles left on objects such as towels and faucet handles. Some people with adenovirus gastroenteritis may shed the virus in their stools for months after getting over the symptoms. The virus can be passed from one person to another through some sexual practices, and through water in swimming pools that do not have enough chlorine in them. As with many other illnesses, good handwashing is one way to lessen the spread of adenoviruses from one person to another. Heat and bleach will kill adenoviruses on objects. As with all viruses, there are no antibiotics that help with an adenoviral infection, so treatment is largely directed at the symptoms . A doctor may give antibiotic eyedrops for conjunctivitis, since it takes a while to test to see if the eye infection is bacterial or viral and to help prevent secondary bacterial infections. In the past, US military recruits were vaccinated against two serotypes of adenotypes, with a corresponding decrease in illnesses caused by those serotypes. The vaccine is no longer manufactured, and there are currently no vaccines available to protect against the adenovirus. Good hygiene, including handwashing, is still the best way to avoid picking up the adenovirus from an infected person. (From the Wikpedia article Adenoviridae.)

Download PDF containing detailed information.PDF Version

Image Results

Loading...

Recent Publications on Adenoviridae:

Pubmed Logo
S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo.
OBJECTIVE: Vascular smooth muscle cell (VSMC) proliferation plays an...
13th November, 2009
Department of Cardiovascular Medicine and Medical Research, Mackay J Vasc Surg. 2009 Nov;50(5):1135-42.
DOI Direct Link
Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase homologues in the vasopressor and dipsogenic effects of brain angiotensin II.
The renin-angiotensin system exerts a tremendous influence over fluid...
13th November, 2009
Department of Cell and Developmental Biology, Weill Cornell Medical Hypertension. 2009 Nov;54(5):1106-14. Epub 2009 Oct 5.
DOI Direct Link
Effect of recombinant placental growth factor 2 on hypertension induced by full-length mouse soluble fms-like tyrosine kinase 1 adenoviral vector in pregnant mice.
The first aim of our study was to develop a pregnant mouse model for...
13th November, 2009
Department of Obstetrics and Gynecology, Jichi Medical University School Hypertension. 2009 Nov;54(5):1129-35. Epub 2009 Sep 28.
DOI Direct Link
Efficient inhibition of hepatitis B virus replication in vivo, using polyethylene glycol-modified adenovirus vectors.
Achieving safe delivery of anti-hepatitis B virus (HBV) RNA interference...
11th November, 2009
Department of Molecular Medicine and Hematology, University of the Hum Gene Ther. 2008 Nov;19(11):1325-31.
DOI Direct Link
Persistent infection of turkeys with an avirulent strain of turkey hemorrhagic enteritis virus.
The Virginia avirulent strain (VAS) of turkey hemorrhagic enteritis virus...
11th November, 2009
Center for Molecular Medicine and Infectious Disease, Virginia-Maryland Avian Dis. 2009 Sep;53(3):370-5.

View more research publications.

BioNews Results for Adenoviridae:

RSS Logo
BioPortfolio Logo
Cancer Gene Therapy Vaccines: Researchers from School of Medicine publish findings in cancer gene therapy vaccines
NewsRX:  Nov 3 2009 5:10AM Matching: adenoviridae

Adenoviridae Clinical Trials:

Clinical Trials Logo
Safety, Toxicity and Maximum Tolerated Dose (MTD) of One Intravenous IV Injection of Donor Cytotoxic T-Lymphocytes (CTLs) Specific for Cytomegalovirus (CMV) and Adenovirus

Adenoviridae Patents:

USPTO Logo
US Patent No.Title
7517520 Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use
7569217 Porcine adenovirus E1 and E4 regions
7569383 Chimeric flavivirus vectors
7569384 Albumin fusion proteins
7569553 Nucleic acid compositions for stimulating immune responses

View more patents.

BioPortfolio Ltd. offers e-mail and postal lists for Adenoviridae scientists - we have details of around 2095 individuals working on Adenoviridae .


This page has been viewed 773 times
Recent Search Terms used to find this page: how does adenoviridae spread | Adenoviridae Infection treatment | adenoviridae humans | where are adenoviridae viruses located | where are adenoviridae viruses located | Adenoviridae test | shed and spread capabilities of reconbinant adenovirus | Adenoviridae | conjunctivitis with Adenoviridae | .
Browse BioPortfolio's InDepth service - alphabetically: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z or by Most Publications, recently searched for, or most viewed.

Search for Adenoviridae across BioPortfolio, or for Adenoviridae Research Reports
Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.