Adrenoleukodystrophy

Adrenoleukodystrophy is a rare inherited disorder that leads to progressive brain damage, failure of the adrenal gland and eventually death. ALD is one of a group of inherited disorders called Leukodystrophies progressively damaging the myelin, a complex fatty neural tissue that insulates many nerves of the central and peripheral nervous systems. Without myelin, nerves are unable to conduct an impulse, leading to increasing disability as myelin destruction increases and intensifies. An essential protein, called a transporter protein, is missing in sufferers. This protein is needed to carry an enzyme which is used to break down long chain fatty acids found in the normal diet. A build up of these long chain fatty acids in the body due to this can cause damage to the brain and the adrenal gland. The victims of ALD are nearly always male, with about one in five women carrying the disease developing a milder form in adult life. There are several different types of the disease which can be inherited in two different ways. It is more commonly inherited as an X-linked condition. Although this disorder affects the growth and/or development of myelin, Leukodystrophies are different from demyelinating disorders such as multiple sclerosis where myelin is formed normally but is lost by immunologic dysfunction or for other reasons. (From the Wikpedia article Adrenoleukodystrophy.)

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Recent Publications on Adrenoleukodystrophy:
Clinical profile of adrenoleukodysrophy. X-linked Adrenoleukodystrophy (ALD) is the most common of the peroxisomal...	13th November, 2009	Department of Endocrinology, Seth GS Medical College and KEM Hospital,	Indian J Pediatr. 2009 Oct;76(10):1045-7. Epub 2009 Nov 12. DOI Direct Link
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. X-linked adrenoleukodystrophy (ALD) is a severe brain demyelinating...	7th November, 2009	INSERM UMR745, University Paris-Descartes, 75279 Paris, France.	Science. 2009 Nov 6;326(5954):818-23. DOI Direct Link
Manifestation of neurofibromatosis 1 in a patient with X-linked adrenoleukodystrophy. A patient with X-linked adrenoleukodystrophy exhibited a phenotype of...	27th October, 2009	Department of Pediatrics and Child Neurology, Oita University, 1-1	Pediatr Neurol. 2009 Sep;41(3):211-4. DOI Direct Link
Twenty years of dysuria in a patient with Addison's disease: a case report. X-linked adrenoleukodystrophy is an X-linked recessive disorder affecting...	16th October, 2009	Department of Internal Medicine, Atlanta Medical Center 303 Parkway Drive	Cases J. 2009 Jun 15;2:7995. DOI Direct Link
Peroxisomal and mitochondrial status of two murine oligodendrocytic cell lines (158N, 158JP): potential models for the study of peroxisomal disorders associated with dysmyelination processes. In some neurodegenerative disorders (leukodystrophies) characterized by...	10th October, 2009	Centre de Recherche INSERM, Dijon, France.	J Neurochem. 2009 Oct;111(1):119-31. Epub 2009 Jul 29. DOI Direct Link
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BioNews Results for Adrenoleukodystrophy:
Genetix Pharmaceuticals Announces Global Clinical Plans to Treat Adrenoleukodystrophy (ALD)	Reuters:  Nov 12 2009 5:38PM Matching: adrenoleukodystrophy
Genetix Pharmaceuticals Announces Global Clinical Plans to Treat Adrenoleukodystrophy (ALD)	Street Insider:  Nov 12 2009 5:29PM Matching: adrenoleukodystrophy
Genetix Pharmaceuticals Announces Global Clinical Plans to Treat Adrenoleukodystrophy (ALD)	FinanzNachrichten.de:  Nov 12 2009 5:17PM Matching: adrenoleukodystrophy
Genetix Pharmaceuticals Announces Global Clinical Plans to Treat Adrenoleukodystrophy (ALD)	Globe Investor:  Nov 12 2009 5:11PM Matching: adrenoleukodystrophy
Genetix Pharmaceuticals Announces Global Clinical Plans to Treat Adrenoleukodystrophy (ALD)	Yahoo! Canada:  Nov 12 2009 5:47PM Matching: adrenoleukodystrophy
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Adrenoleukodystrophy Clinical Trials:
A Phase III Trial of Lorenzo's Oil in Adrenomyeloneuropathy

Adrenoleukodystrophy Patents:
US Patent No.	Title
7438910	Therapeutic human anti-IL1-R1 monoclonal antibody
7498171	Modulation of stem and progenitor cell differentiation, assays, and uses thereof
7501123	Human G-protein chemokine receptor (CCR5) HDGNR10
7504489	Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof
7507413	Albumin fusion proteins
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BioPortfolio Ltd. offers e-mail and postal lists for Adrenoleukodystrophy scientists - we have details of around 159 individuals working on Adrenoleukodystrophy .