Alkylation

Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene . Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Many biological target molecules or their synthetic precursors comprise of an alkyl chain, with specific functional groups in a specific order. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor.In oil refining contexts, alkylation refers to a particular alkylation of isobutane with olefins. It is a major aspect of the upgrading of petroleum. (From the Wikpedia article Alkylation.)

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Recent Publications on Alkylation:
3-(2-Aminophenyl)-4-methyl-1,3-thiazole-2(3H)-thione as an Ecofriendly Sulphur Transfer Agent to Prepare Alkanethiols in High Yield and High Purity. A new process is described for preparing very pure linear alkanethiols and...	20th November, 2009	Laboratoire de synthese organique appliquee, Departement de Chimie,	Molecules. 2009 Nov 12;14(11):4634-4643. DOI Direct Link
Complete Mapping of the Stereochemical Course of Retentive Deprotonation/Alkylation of 1H-Benzo[e][1,4]diazepin-2(3H)-ones. Enantiopure amino-acid derived 1H-benzo[e][1,4]diazepin-2(3H)-ones (BZDs)...	20th November, 2009	Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061.	J Am Chem Soc. 2009 Nov 18. DOI Direct Link
Construction of Two Vicinal Quaternary Carbons by Asymmetric Allylic Alkylation: Total Synthesis of Hyperolactone C and (-)-Biyouyanagin A. Enantiopure amino-acid derived 1H-benzo[e][1,4]diazepin-2(3H)-ones (BZDs)...	19th November, 2009	State Key Laboratory of Applied Organic Chemistry, College of Chemistry	Angew Chem Int Ed Engl. 2009 Nov 17;48(49):9211. DOI Direct Link
Ab initio study of alkylation of Guanine-Cytosine base pair by sulfur and nitrogen mustards. Quantum modeling of the N7(G) alkylation of guanine-cytosine (G-C) base...	18th November, 2009	UNSA, ParcValrose	J Biomol Struct Dyn. 2010 Feb;27(4):465-76.
[Sequence-specific interaction of pyrimidine oligonucleotides with double-stranded DNA at acidic pH complexes of different types.] The interaction of pyrimidine oligonucleotides (OLN(15) and OLN(6)) and...	17th November, 2009	Institute of Clinical Immunology, Russian Academy of Medical Sciences, ul.	Bioorg Khim. 2009 Sep-Oct;35(5):657-64.
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Press Releases About Alkylation:
Reportlinker Adds Chinese Markets for Anti-Tumor Drugs	5th November, 2009	Reportlinker	NEW YORK, Nov. 5 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue. Chinese Markets for Anti-Tumor Drugs http://www.reportlinker.com/p0157397

Alkylation Clinical Trials:
SentoClone® Compared to Reference Treatment in Advanced Malignant Melanoma

Alkylation Patents:
US Patent No.	Title
7615563	Compositions useful as inhibitors of voltage-gated sodium channels
7615647	Process for producing atorvastatin hemicalcium
7618544	Fiber film reactors to effect separation and reaction between two immiscible reaction components
7618560	Stable metal/conductive polymer composite colloids and methods for making and using the same
7618617	Aqueous hair treatment compositions, thickened with an amphiphilic linear block copolymer
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