Anaphylaxis

Anaphylaxis is an acute systemic and severe Type I Hypersensitivity allergic reaction in humans and other mammals. The term comes from the Greek words ανα ana and φύλαξις phylaxis . Anaphylaxis occurs when a person or animal is exposed to a trigger substance, called an allergen, to which they have already become sensitized. Minute amounts of allergens may cause a life-threatening anaphylactic reaction. Anaphylaxis may occur after ingestion, skin contact, injection of an allergen or, in rare cases, inhalation. Anaphylactic shock, the most severe type of anaphylaxis, occurs when an allergic response triggers a quick release from mast cells of large quantities of immunological mediators leading to systemic vasodilation and edema of bronchial mucosa . Anaphylactic shock can lead to death in a matter of minutes if left untreated.An estimated 1.24% to 16.8% of the population of the United States is considered "at risk" for having an anaphylactic reaction if they are exposed to one or more allergens, especially penicillin and insect stings. Most of these people successfully avoid their allergens and will never experience anaphylaxis. Of those people who actually experience anaphylaxis, up to 1% may die as a result. Anaphylaxis results in fewer than 1,000 deaths per year in the U.S. . The most common presentation includes sudden cardiovascular collapse .Researchers typically distinguish between "true anaphylaxis" and "pseudo-anaphylaxis or an anaphylactoid reaction." The symptoms, treatment, and risk of death are identical, but "true" anaphylaxis is always caused directly by degranulation of mast cells or basophils that is mediated by immunoglobulin E , and pseudo-anaphylaxis occurs due to all other causes. The distinction is primarily made by those studying mechanisms of allergic reactions. (From the Wikpedia article Anaphylaxis.)

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Recent Publications on Anaphylaxis:
Acute stent thrombosis in a sirolimus eluting stent after wasp sting causing acute myocardial infarction: a case report. INTRODUCTION: Hymenoptera venoms contain thrombogenic substances that...	18th November, 2009	Department of Cardiology, Ludwig-Maximilians-University Munich, Germany	Cases J. 2009 Aug 12;2:7800. DOI Direct Link
State of the art and new horizons in the diagnosis and management of egg allergy. Egg allergy is one of the most frequent food allergies in children below...	17th November, 2009	Children's Hospital, Geneva University Hospitals, Geneva, Switzerland.	Allergy. 2009 Nov 12. DOI Direct Link
The prophylaxis of infective endocarditis: a joint position study of the Italian Federation of Cardiologists and the Italian Society of Infectious and Tropical Diseases. BACKGROUND: Antibiotic prophylaxis of patients believed to be at a risk of...	17th November, 2009	aDivisione di Cardiologia, Ospedale Maria Vittoria di Torino, Italy	J Cardiovasc Med (Hagerstown). 2009 Nov 11. DOI Direct Link
Measles vaccine adverse events reported in the mass vaccination campaign of Sichuan province, China from 2007 to 2008. The aim of this study was to characterize the adverse events of attenuated...	17th November, 2009	Department of Paediatrics, West China Second Hospital, Sichuan University,	Vaccine. 2009 Nov 9. DOI Direct Link
[Wheat-dependent, exercise-induced anaphylaxis.] Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a rare...	13th November, 2009	Klinik fur Allergologie und Dermatologie, Universitatsklinikum RWTH	Hautarzt. 2009 Nov 13. DOI Direct Link
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Press Releases About Anaphylaxis:
Dey Launches and Unveils Next-Generation, Needle-Protected EpiPen(R) (Epinephrine) Auto-Injector with Enhanced Patient-Friendly Features	26th October, 2009	Dey Pharma L.P.	-- bright orange colors and arrows to help quickly identify the needle end of the device and reduce the risk of accidental thumb puncture. Importantly, any patient that currently
FDA Approves Elitek(R) (rasburicase) for Management of Plasma Uric Acid Levels in Adults with Leukemia, Lymphoma, and Solid Tumors Receiving Anti-Cancer Therapy	16th October, 2009	sanofi-aventis	BRIDGEWATER, N.J., Oct. 16 /PRNewswire-FirstCall/ -- Sanofi-aventis U.S. announced that the U.S. Food and Drug Administration (FDA) has granted marketing approval for Elitek® (rasburicase) to be used
Robert F. Kennedy, Jr. Announces New Food Allergy Initiative Advocacy Steering Committee	14th May, 2009	Food Allergy Initiative	Leading parent advocates from across the country join forces to advocate for more research funding to find a cure WASHINGTON, May 14 /PRNewswire-USNewswire/ -- Today, as we continue to mark Food
FDA Approves New Indication for Wyeth's TYGACIL (tigecycline) for the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia	24th March, 2009	Wyeth Pharmaceuticals	Indication Offers New Option for Adult Patients Suffering From Community-Acquired Bacterial Pneumonia COLLEGEVILLE, Pa., March 24 /PRNewswire-FirstCall/ -- Wyeth Pharmaceuticals, a division of
'Take Action, Prevent Reactions' at FAAN's Annual Food Allergy Conferences	20th February, 2009	Food Allergy & Anaphylaxis Network	FAIRFAX, Va., Feb. 20 /PRNewswire-USNewswire/ -- Registration for the Food Allergy & Anaphylaxis Network's (FAAN) 16th annual Food Allergy Conferences is now open. Anyone who has a food

BioNews Results for Anaphylaxis:
Hypersensitivity Therapy: Researchers from University of Wurzburg describe findings in hypersensitivity therapy	NewsRX:  Nov 21 2009 5:48AM Matching: anaphylaxis
GSK Recalls One Lot of H1N1 Vaccine Over Anaphylaxis Concerns	FDA News:  Nov 21 2009 4:47AM Matching: anaphylaxis
Food allergies among children is increasing: Study	News-Medical.Net:  Nov 17 2009 7:03AM Matching: anaphylaxis
Pediatrics, Anaphylaxis	Abstracts in Hematology and Oncology:  Nov 16 2009 11:57PM Matching: anaphylaxis
Child Food Allergies on the Rise in U.S	National Womens Health Information Center:  Nov 16 2009 4:27PM Matching: anaphylaxis
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Anaphylaxis Clinical Trials:
A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis

Anaphylaxis Patents:
US Patent No.	Title
7585968	Compositions and their uses directed to thymus and activation-regulated chemokine (TARC)
7595397	Compounds which modulate the CB2 receptor
7596411	Apparatus and method for two-component bioelectrical impedance ratio measuring and monitoring
7597886	Tumor necrosis factor-gamma
7597894	Compositions and methods employing alternative reading frame polypeptides for the treatment of cancer and infectious disease
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