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Angiostatins

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Recent Publications on Angiostatins:

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Inhibitory effect of angiostatins on activity of the plasminogen/plasminogen activator system.
Angiostatins, kringle-containing fragments of plasminogen, are potent...
18th November, 2009
Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119991, Biochemistry (Mosc). 2009 Oct;74(10):1104-13.
Nicked {beta}2-glycoprotein I binds angiostatin 4.5 (plasminogen kringle 1-5) and attenuates its antiangiogenic property.
Angiostatin was first discovered as a plasminogen fragment with...
23rd October, 2009
Department of Medicine II, Hokkaido University Graduate School of Blood. 2009 Sep 17;114(12):2553-9. Epub 2009 Jul 22.
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Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins.
Angiostatin, a proteolytic fragment of plasminogen, is a potent endogenous...
23rd September, 2009
Department of Surgery, Children's Hospital Boston and Harvard Medical Blood. 2009 Aug 27;114(9):1987-98. Epub 2009 May 22.
DOI Direct Link
Maternal administration of anti-angiogenic agents, TNP-470 and Angiostatin4.5, induces fetal microphthalmia.
PURPOSE: Agents specifically targeting the vasculature as a mode of...
15th September, 2009
Academic Division of Obstetrics and Gynaecology, Nottingham City Hospital, Mol Vis. 2009 Jun 26;15:1260-9.
Tumoristatic effects of endostatin in prostate cancer is dependent on androgen receptor status.
BACKGROUND: Although anti-angiogenic therapy is a promising new line of...
23rd June, 2009
Department of Pathology, The University of Alabama at Birmingham, Prostate. 2009 Jul 1;69(10):1055-66.
DOI Direct Link

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Angiostatins Clinical Trials:

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In Vivo Angiostatin Generation Using Tissue Plasminogen Activator and Captopril in Treating Patients With Progressive Metastatic Cancer

Angiostatins Patents:

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US Patent No.Title
7561973 Methods for determining properties that affect an expression property value of polynucleotides in an expression system
6617354 Method of stabilizing and potentiating the action of anti-angiogenic substances
6657054 Regulated angiogenesis genes and polypeptides
6727347 Method for preparing polycation based bioconjugates suitable for transporting different kinds of active substances within the body
6797488 Methods of producing anti-angiogenic proteins

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BioPortfolio Ltd. offers e-mail and postal lists for Angiostatins scientists - we have details of around 49 individuals working on Angiostatins .


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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org

 

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