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Brachytherapy

Brachytherapy, also known as sealed source radiotherapy or endocurietherapy, is a form of radiotherapy where a radioactive source is placed inside or next to the area requiring treatment. Conversely, external beam radiotherapy, or teletherapy, is the application of radiation that has been externally produced by a linear accelerator. Brachytherapy is commonly used to treat localized prostate cancer and cancers of the head and neck.Brachy is from a Greek word for "short", so brachytherapy roughly translated is short distance therapy.Brachytherapy can be split into five main types:* Mold brachytherapy. Superficial tumours can be treated using sealed sources placed close to the skin. Dosimetry is often performed with reference to the Manchester system; a rule-based approach designed to ensure that the dose to all parts of the target volume is within 10% of the prescription dose.* Surface Applicator is usually called Strontium plaque therapy and is used for very superficial lesions less than 1 mm thick. The plaque is a hollow, thin silver casing that encloses a radioactive Strontium-90 powdered salt. The beta particles produced from Strontium's radioactive decay have a very shallow penetration. Typically the Sr90 plaque is placed on the bed of a resected pterygium. A stat dose of around 10-12 Gy is delivered by timing the contact. As the electrons only penetrate a few mm of air, radiation protection issues are slightly less but very different to other radiation sources. Cleaning the plaques that are placed on the eye sclera is required but must be gentle because the silver casing is thin and easily damaged. Strontium belongs to the same chemical class as Calcium, i.e., an alkaline earth metal, and so will co-locate in the bone if any strontium salt makes contact with the eye and is absorbed. Operators can prevent exposure to the beta rays by facing the applicator away from their bodies.* Interstitial brachytherapy. Here the sources are inserted into tissue. The first treatments of this kind used needles containing Radium-226, arranged according to the Manchester system, but modern methods tend to use Iridium-192 wire. Iridium wire can be arranged either using the Manchester or the Paris system; the latter was designed specifically to take advantage of the new nuclide. Prostate cancer treatment with Iodine-125 seeds is also classified as interstitial brachytherapy. For details of the gamma emitters please see commonly used gamma emitting isotopes.* Intracavitary brachytherapy places the sources inside a pre-existing body cavity. The most common applications of this method are gynaecological in nature, although it can also be performed on the nasopharynx.* Intravascular brachytherapy places a catheter with the sources inside the vasculature. The most common application of this method is the treatment of coronary in-stent restenosis, although the therapy has also been investigated for use in the treatment of peripheral vasculature stenoses. (From the Wikpedia article Brachytherapy.)

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Recent Publications on Brachytherapy:

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Trends in non-metastatic prostate cancer management in the Northern and Yorkshire region of England, 2000-2006.
Background:Our objective was to analyse variation in non-metastatic...
12th November, 2009
Northern and Yorkshire Cancer Registry and Information Service, Level 6, Br J Cancer. 2009 Nov 10.
DOI Direct Link
[Prostate cancer treatments in Belgium]
The authors present a flyover of current management of prostate cancer....
11th November, 2009
Service d'Urologie, Hopital Erasme, Bruxelles. Rev Med Brux. 2009 Sep;30(4):270-8.
A dosimetric selectivity intercomparison of HDR brachytherapy, IMRT and helical tomotherapy in prostate cancer radiotherapy.
BACKGROUND AND PURPOSE: Dose escalation in order to improve the...
10th November, 2009
Department of Radiation Oncology, Liege University Hospital, Liege, Strahlenther Onkol. 2009 Nov;185(11):736-42. Epub 2009 Nov 10.
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Use of gold markers for setup in image-guided fractionated high-dose-rate brachytherapy as a monotherapy for prostate cancer.
BACKGROUND AND PURPOSE: In order to use a single implant with one...
10th November, 2009
Department of Radiation Oncology with Division of Medical Radiation Strahlenther Onkol. 2009 Nov;185(11):731-5. Epub 2009 Nov 10.
DOI Direct Link
Chemoradiation in locally advanced cervical carcinoma: An analysis of cisplatin dosing and other clinical prognostic factors.
OBJECTIVES: The aim of this study was to evaluate the effect of number of...
10th November, 2009
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Gynecol Oncol. 2009 Nov 4.
DOI Direct Link

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Press Releases About Brachytherapy:

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L.A. Zoo Announces Successful Cancer Treatment of Rhinoceros With Electronic Brachytherapy 16th November, 2009 Xoft, Inc.
LOS ANGELES, Nov. 16 /PRNewswire/ -- The Los Angeles Zoo announced that Randa, a 40-year-old Indian rhinoceros, has successfully completed treatment for skin cancer using a breakthrough cancer
Xoft Showcases Multi-Disciplinary Electronic Brachytherapy Cancer Treatment Platform at ASTRO 2nd November, 2009 Xoft, Inc.
CHICAGO, Nov. 2 /PRNewswire/ -- Xoft, Inc., developer of the Axxent(®) Electronic Brachytherapy, eBx(TM) System, which delivers non-radioactive, electronic therapy directly to cancer sites with
Reportlinker Adds Prefeasibility Report - Specaility and Multi- Speciality Hospitals (2009) 26th October, 2009 Reportlinker
NEW YORK, Oct. 26 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue. Reportlinker Adds Prefeasibility Report - Specaility and Multi- Speciality
Electronic Brachytherapy a Viable Option for Intraoperative Radiation Therapy (IORT) 12th October, 2009 Xoft, Inc.
CHICAGO, Oct. 12 /PRNewswire/ -- Clinical experience with the FDA cleared Axxent® Electronic Brachytherapy, eBx(TM), System from Xoft shows promise for the multi-disciplinary use of the isotope-free
New Report Just Published: World Prostate Cancer Therapeutics Market Report 7th July, 2009 Reportlinker
NEW YORK, July 7 /PRNewswire/ -- Reportlinker.com just added a new market research report to its catalogue. World Prostate Cancer Therapeutics Market http://www.reportlinker.com/p0119471/World

BioNews Results for Brachytherapy:

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NeoVista, Inc. Announces First Neovascular AMD Patient Treated with VIDION ANV Therapy System in Europe Follow
Pharmacy Choice:  Nov 12 2009 10:11PM Matching: brachytherapy
SAVI Brachytherapy for Breast Cancer Marks 3 Years of Treatment
Individual.com:  Nov 11 2009 6:15AM Matching: brachytherapy
SAVI Brachytherapy for Breast Cancer Marks Three-Year Anniversary of First Treatment
Business Wire via Yahoo!:  Nov 9 2009 1:59PM Matching: brachytherapy
SAVI Brachytherapy for Breast Cancer Marks Three-Year Anniversary of First Treatment
Business Wire:  Nov 9 2009 1:45PM Matching: brachytherapy
SAVI Brachytherapy for Breast Cancer Marks Three-Year Anniversary of First Treatment
Street Insider:  Nov 9 2009 1:42PM Matching: brachytherapy
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Brachytherapy Clinical Trials:

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Long-Term Outcomes of Alternative Brachytherapy Techniques for Early Prostate Cancer

Brachytherapy Patents:

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US Patent No.Title
7540998 Delivery system and prescription method for interstitial radiation therapy using enhanced parametric release sterilization techniques
7557251 Production of gossypol co-crystals
7559905 HIFU probe for treating tissue with in-line degassing of fluid
7560531 Cln101 antibody compositions and methods of use alone and in combination with prostate specific antigen and other cancer markers
7563222 Methods and apparatus for intraocular brachytherapy

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Companies working in the area of Brachytherapy from Bioportfolio's Biocorporate database :

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Company Name

CET CANCER CENTER

California Endocurietherapy Cancer Center (CET) is the first brachytherapy only center in the United States.
Founded by D Jeffrey Demanes M.D. in 1981.
Dedicated solely to High Dose Rate...
www.cetmc.com/        View full profile
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GammaWest Brachytherapy

Brachytherapy is an advanced cancer treatment. The word "brachy" is Greek for "close by" and refers to placing radioactive seeds or sources directly in the tumor. This procedure gives physicians and...
www.gammawest.com/        View full profile
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Mick Radio-Nuclear Instruments, Inc.

Mick Radio-Nuclear Instruments, Inc., known internationally for its 30+ years of service to the Radiation Therapy community, provides high-quality and state-of-the-art instrumentation and accessories...
www.micknuclear.com/        View full profile
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BioPortfolio Ltd. offers e-mail and postal lists for Brachytherapy scientists - we have details of around 1299 individuals working on Brachytherapy .


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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org

 

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