Bromodeoxyuridine

Bromodeoxyuridine is a synthetic nucleoside which is an analogue of thymidine. BrdU is commonly used in the detection of proliferating cells in living tissues.BrdU can be incorporated into the newly synthesized DNA of replicating cells , substituting for thymidine during DNA replication. Antibodies specific for BrdU can then be used to detect the incorporated chemical , thus indicating cells that were actively replicating their DNA. Binding of the antibody requires denaturation of the DNA, usually by exposing the cells to acid or heat. Because BrdU can replace thymidine during DNA replication, it can cause mutations, and its use is therefore potentially a health hazard. (From the Wikpedia article Bromodeoxyuridine.)

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Recent Publications on Bromodeoxyuridine:
Time-dependent segmentation of BrdU-signal leads to late detection problems in studies using BrdU as cell label or proliferation marker. Bromodeoxyuridine incorporates into DNA during mitosis. A long-term...	15th November, 2008	Leibniz Institute for Neurobiology (IfN), Brenneckestr. 6, 39118	J Neurosci Methods. 2008 Oct 21. DOI Direct Link
An organotypical in vitro model for vascular tissue remodelling and its application to study radiation effects. An organotypic in vitro model, to study vascular tissueremodeling, was...	13th November, 2008	Laboratory for Histology, Faculty of Medicine, Ghent University, L.	Cytotechnology. 2000 Nov;34(3):185-95. DOI Direct Link
Identity, developmental restriction and reactivity of extralaminar cells capping mammalian neuromuscular junctions. Neuromuscular junctions (NMJs) are normally thought to comprise three...	13th November, 2008		J Cell Sci. 2008 Nov 11. DOI Direct Link
Bromodeoxyuridine photodamage in studies of UVA damage and the cell cycle. Neuromuscular junctions (NMJs) are normally thought to comprise three...	13th November, 2008	Department of Radiology, The Ohio State University, Innovation Center,	DNA Repair (Amst). 2008 Nov 7. DOI Direct Link
Ablation of NF-kappaB expression by small interference RNA prevents the dysfunction of human umbilical vein endothelial cells induced by high glucose. Diabetes is a major independent risk factor for cardiovascular disease and...	11th November, 2008	Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical	Endocrine. 2008 Nov 8. DOI Direct Link
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BioNews Results for Bromodeoxyuridine:
Findings in cancer reported from University of Florida	Calibre Macro World:  Oct 24 2008 1:54AM Matching: bromodeoxyuridine

Bromodeoxyuridine Clinical Trials:
Broxuridine Plus Surgery in Treating Patients With Stage I or Stage II Prostate Cancer	Prostate Cancer

Bromodeoxyuridine Patents:
US Patent No.	Title
7378274	Regulatory nucleic acid for the ABC1 gene, molecules modifying its activity and therapeutic uses
7393938	Use of lipid conjugates in the treatment of diseases
7396663	Isolated polynucleotide encoding a G-protein coupled receptor
7396669	Mammalian endonucleases and methods of use
7399480	Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices
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