Calcineurin

Calcineurin is a protein phosphatase also known as protein phosphatase 2B . Calcineurin is responsible for activating the transcription of interleukin 2 , that stimulates the growth and differentiation of T cell response. In immunosuppressive therapy it is inhibited by cyclosporin, pimecrolimus and tacrolimus - these drugs are known as calcineurin inhibitors. Calcineurin dephosphorylates NFATc, a transcription factor that can then go into the nucleus and turn on genes involved in IL-2 synthesis. (From the Wikpedia article Calcineurin.)

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Recent Publications on Calcineurin:
Pharmacogenetics of Crohn's disease. The considerable interindividual differences in efficacy and side effects...	4th July, 2008	University of Munich, Department of Internal Medicine II, Campus	Pharmacogenomics. 2008 Jul;9(7):881-93. DOI Direct Link
Successful Treatment of Class V+IV Lupus Nephritis with Multitarget Therapy. Treatment of class V+IV lupus nephritis remains unsatisfactory despite the...	4th July, 2008	Research Institute of Nephrology, Jinling Hospital, Nanjing University	J Am Soc Nephrol. 2008 Jul 2;. DOI Direct Link
Novel calcineurin interacting protein-2: the functional characterization of CNP-2 in Caenorhabditis elegans. Calcineurin (Cn) is a serine/threonine phosphatase implicated in a wide...	3rd July, 2008	Department of Life Science, Hanyang University, Seoul 133-791, Korea	BMB Rep. 2008 Jun 30;41(6):455-60.
Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light. PP2B is a Ca(2+)/calmodulin-dependent protein phosphatase that is...	2nd July, 2008	Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia,	Pharmacol Biochem Behav. 2008 Jun 4;. DOI Direct Link
Altered first-pass effects in a liver transplant recipient explained intraindividual variation in calcineurin inhibitor concentrations: a case report. BACKGROUND: The significant interindividual and intraindividual...	1st July, 2008	Clinical Pharmacology Division, Department of Medicine, Indiana University	Transplant Proc. 2008 Jun;40(5):1789-91. DOI Direct Link
→View more research publications.

BioNews Results for Calcineurin:
TopAbstracts in Organ Transplantation 06/26/2008	Doctors Guide:  Jun 28 2008 1:31AM Matching: calcineurin
Lux Biosciences Completes Enrollment in LUMINATE Pivotal Trial Program for Novel Uveitis Therapy, Luveniq	Pharma Live:  Jun 26 2008 9:15AM Matching: calcineurin
Lux Biosciences Completes Enrollment in LUMINATE Pivotal Trial Program for Novel Uveitis Therapy, LUVENIQ(TM)	Earthtimes.org:  Jun 25 2008 12:29PM Matching: calcineurin
Full Enrollment Achieved in Luminate Pivotal Trial Program for Novel Uveitis Therapy, Voclosporin	Pharma Live:  Jun 26 2008 4:38PM Matching: calcineurin
Lux Biosciences Completes Enrollment in LUMINATE Pivotal Trial Program for Novel Uveitis Therapy, LUVENIQ(TM)	DiGiTAL50:  Jun 26 2008 9:58AM Matching: calcineurin
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Calcineurin Clinical Trials:
Induction Treatment Followed by Immunosuppression Withdrawal in Liver Transplantation: a Comparative Trial.	Liver Diseases
Liver Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Sirolimus in Recipients of a Liver Transplant	Liver Transplantation
Preservation of Renal Function in Liver Transplant Recipients With Certican Therapy	Liver Transplantation
Enteric Coated Myfortic for Liver Transplant Recipients	Liver Transplantation
TUMORAPA 1: Efficacy of Rapamycin in Secondary Prevention of Skin Cancers in Kidney Transplant Recipients	Skin Cancer;   Kidney Transplantation
→View more trials.

Calcineurin Patents:
US Patent No.	Title
7312044	Type 1 ryanodine receptor-based methods
7338782	Nucleic acids encoding chromophores/fluorophores and methods for using the same
7338783	Nucleic acids encoding chromophores/fluorophores and methods for using the same
7338784	Nucleic acids encoding chromophores/fluorophores and methods for using the same
7338785	Nucleic acids encoding chromophores/fluorophores and methods for using the same
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