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CalcineurinCalcineurin is a protein phosphatase also known as protein phosphatase 2B . Calcineurin is responsible for activating the transcription of interleukin 2 , that stimulates the growth and differentiation of T cell response. In immunosuppressive therapy it is inhibited by cyclosporin, pimecrolimus and tacrolimus - these drugs are known as calcineurin inhibitors. Calcineurin dephosphorylates NFATc, a transcription factor that can then go into the nucleus and turn on genes involved in IL-2 synthesis. (From the Wikpedia article Calcineurin.) Download PDF containing detailed information.
Recent Publications on Calcineurin: |  |
Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells.
Vascular smooth muscle cells (SMC) display remarkable phenotypic... | 21st November, 2009
| Dept. of Medicine, Cardiovascular Division, Univ. of Virginia,
| Hum Mol Genet. 2009 Nov 19.
DOI Direct Link |
Tubular Toxicity in Sirolimus- and Cyclosporine-Based Transplant Immunosuppression Strategies: An Ancillary Study From a Randomized Controlled Trial.
BACKGROUND: Sirolimus has been promoted as an agent to provide... | 21st November, 2009
| Clinic for Transplantation Immunology and Nephrology, University Hospital,
| Am J Kidney Dis. 2009 Nov 16.
DOI Direct Link |
Sirolimus: A Novel Immunosuppressive Drug in Heart Transplantation.
Cardiac transplantation is a time-honored therapy for end stage heart... | 21st November, 2009
| Division of Cardiology, University of Texas Medical Branch-Galveston, 301
| Recent Pat Cardiovasc Drug Discov. 2009 Nov;4(2):187-191.
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Inhibition of the Calcineurin-NFAT Signalling Cascade in the Treatment of Heart Failure.
Calcineurin (Cn), a serine/threonine phosphatase, plays a crucial role in... | 21st November, 2009
| Department of Medicine I, University of Wuerzburg, Wuerzburg, Germany.
| Recent Pat Cardiovasc Drug Discov. 2009 Nov;4(2):180-186.
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Role of Cellular Cholesterol in Pharmacologic Preconditioning with Cyclosporine in Experimental Kidney Transplantation.
Background/Aims: Ischemia reperfusion injury in the early posttransplant... | 20th November, 2009
| Division of Nephrology, University of Utah School of Medicine, Salt Lake
| Am J Nephrol. 2009 Nov 17;31(2):134-140.
DOI Direct Link |
→View more research publications. |
Press Releases About Calcineurin:
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| Emerging Therapies Could Help Ease The Chronic Symptoms of Atopic Dermatitis For Adults and Children |
5th March, 2009 |
American Academy of Dermatology |
SAN FRANCISCO, March 5 /PRNewswire-USNewswire/ -- Atopic dermatitis, the common, chronic, inflammatory skin disease marked by red, itchy rashes, has been increasing in prevalence over the past two
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| Isotechnika Presents Positive Data From the Promise Trial of Voclosporin at the American Transplant Congress |
4th June, 2008 |
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EDMONTON, Canada, June 4 /PRNewswire/ -- Isotechnika Inc. today announces the successful results of the Phase 2b
PROMISE trial which were presented by Dr. A. Osama Gaber, an investigator for
the
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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
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