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Calcineurin

Calcineurin is a protein phosphatase also known as protein phosphatase 2B . Calcineurin is responsible for activating the transcription of interleukin 2 , that stimulates the growth and differentiation of T cell response. In immunosuppressive therapy it is inhibited by cyclosporin, pimecrolimus and tacrolimus - these drugs are known as calcineurin inhibitors. Calcineurin dephosphorylates NFATc, a transcription factor that can then go into the nucleus and turn on genes involved in IL-2 synthesis. (From the Wikpedia article Calcineurin.)

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Recent Publications on Calcineurin:

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Pharmacogenetics of Crohn's disease.
The considerable interindividual differences in efficacy and side effects...
4th July, 2008
University of Munich, Department of Internal Medicine II, Campus Pharmacogenomics. 2008 Jul;9(7):881-93.
DOI Direct Link
Successful Treatment of Class V+IV Lupus Nephritis with Multitarget Therapy.
Treatment of class V+IV lupus nephritis remains unsatisfactory despite the...
4th July, 2008
Research Institute of Nephrology, Jinling Hospital, Nanjing University J Am Soc Nephrol. 2008 Jul 2;.
DOI Direct Link
Novel calcineurin interacting protein-2: the functional characterization of CNP-2 in Caenorhabditis elegans.
Calcineurin (Cn) is a serine/threonine phosphatase implicated in a wide...
3rd July, 2008
Department of Life Science, Hanyang University, Seoul 133-791, Korea BMB Rep. 2008 Jun 30;41(6):455-60.
Immunosuppressant calcineurin inhibitors phase shift circadian rhythms and inhibit circadian responses to light.
PP2B is a Ca(2+)/calmodulin-dependent protein phosphatase that is...
2nd July, 2008
Laboratorio de Cronobiologia, Departamento de Ciencia y Tecnologia, Pharmacol Biochem Behav. 2008 Jun 4;.
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Altered first-pass effects in a liver transplant recipient explained intraindividual variation in calcineurin inhibitor concentrations: a case report.
BACKGROUND: The significant interindividual and intraindividual...
1st July, 2008
Clinical Pharmacology Division, Department of Medicine, Indiana University Transplant Proc. 2008 Jun;40(5):1789-91.
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BioNews Results for Calcineurin:

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TopAbstracts in Organ Transplantation 06/26/2008
Doctors Guide:  Jun 28 2008 1:31AM Matching: calcineurin
Lux Biosciences Completes Enrollment in LUMINATE Pivotal Trial Program for Novel Uveitis Therapy, Luveniq
Pharma Live:  Jun 26 2008 9:15AM Matching: calcineurin
Lux Biosciences Completes Enrollment in LUMINATE Pivotal Trial Program for Novel Uveitis Therapy, LUVENIQ(TM)
Earthtimes.org:  Jun 25 2008 12:29PM Matching: calcineurin
Full Enrollment Achieved in Luminate Pivotal Trial Program for Novel Uveitis Therapy, Voclosporin
Pharma Live:  Jun 26 2008 4:38PM Matching: calcineurin
Lux Biosciences Completes Enrollment in LUMINATE Pivotal Trial Program for Novel Uveitis Therapy, LUVENIQ(TM)
DiGiTAL50:  Jun 26 2008 9:58AM Matching: calcineurin
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Calcineurin Clinical Trials:

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Induction Treatment Followed by Immunosuppression Withdrawal in Liver Transplantation: a Comparative Trial.
Liver Diseases
Liver Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Sirolimus in Recipients of a Liver Transplant
Liver Transplantation
Preservation of Renal Function in Liver Transplant Recipients With Certican Therapy
Liver Transplantation
Enteric Coated Myfortic for Liver Transplant Recipients
Liver Transplantation
TUMORAPA 1: Efficacy of Rapamycin in Secondary Prevention of Skin Cancers in Kidney Transplant Recipients
Skin Cancer;   Kidney Transplantation

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Calcineurin Patents:

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US Patent No.Title
7312044 Type 1 ryanodine receptor-based methods
7338782 Nucleic acids encoding chromophores/fluorophores and methods for using the same
7338783 Nucleic acids encoding chromophores/fluorophores and methods for using the same
7338784 Nucleic acids encoding chromophores/fluorophores and methods for using the same
7338785 Nucleic acids encoding chromophores/fluorophores and methods for using the same

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BioPortfolio Ltd. offers e-mail and postal lists for Calcineurin scientists - we have details of around 583 individuals working on Calcineurin .


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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
 

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