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Calcineurin

Calcineurin is a protein phosphatase also known as protein phosphatase 2B . Calcineurin is responsible for activating the transcription of interleukin 2 , that stimulates the growth and differentiation of T cell response. In immunosuppressive therapy it is inhibited by cyclosporin, pimecrolimus and tacrolimus - these drugs are known as calcineurin inhibitors. Calcineurin dephosphorylates NFATc, a transcription factor that can then go into the nucleus and turn on genes involved in IL-2 synthesis. (From the Wikpedia article Calcineurin.)

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Recent Publications on Calcineurin:

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Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells.
Vascular smooth muscle cells (SMC) display remarkable phenotypic...
21st November, 2009
Dept. of Medicine, Cardiovascular Division, Univ. of Virginia, Hum Mol Genet. 2009 Nov 19.
DOI Direct Link
Tubular Toxicity in Sirolimus- and Cyclosporine-Based Transplant Immunosuppression Strategies: An Ancillary Study From a Randomized Controlled Trial.
BACKGROUND: Sirolimus has been promoted as an agent to provide...
21st November, 2009
Clinic for Transplantation Immunology and Nephrology, University Hospital, Am J Kidney Dis. 2009 Nov 16.
DOI Direct Link
Sirolimus: A Novel Immunosuppressive Drug in Heart Transplantation.
Cardiac transplantation is a time-honored therapy for end stage heart...
21st November, 2009
Division of Cardiology, University of Texas Medical Branch-Galveston, 301 Recent Pat Cardiovasc Drug Discov. 2009 Nov;4(2):187-191.
Inhibition of the Calcineurin-NFAT Signalling Cascade in the Treatment of Heart Failure.
Calcineurin (Cn), a serine/threonine phosphatase, plays a crucial role in...
21st November, 2009
Department of Medicine I, University of Wuerzburg, Wuerzburg, Germany. Recent Pat Cardiovasc Drug Discov. 2009 Nov;4(2):180-186.
Role of Cellular Cholesterol in Pharmacologic Preconditioning with Cyclosporine in Experimental Kidney Transplantation.
Background/Aims: Ischemia reperfusion injury in the early posttransplant...
20th November, 2009
Division of Nephrology, University of Utah School of Medicine, Salt Lake Am J Nephrol. 2009 Nov 17;31(2):134-140.
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Press Releases About Calcineurin:

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Emerging Therapies Could Help Ease The Chronic Symptoms of Atopic Dermatitis For Adults and Children 5th March, 2009 American Academy of Dermatology
SAN FRANCISCO, March 5 /PRNewswire-USNewswire/ -- Atopic dermatitis, the common, chronic, inflammatory skin disease marked by red, itchy rashes, has been increasing in prevalence over the past two
Isotechnika Presents Positive Data From the Promise Trial of Voclosporin at the American Transplant Congress 4th June, 2008
EDMONTON, Canada, June 4 /PRNewswire/ -- Isotechnika Inc. today announces the successful results of the Phase 2b PROMISE trial which were presented by Dr. A. Osama Gaber, an investigator for the

BioNews Results for Calcineurin:

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Lux Biosciences to Present at Lazard Capital Markets 6th Annual Healthcare Conference
Pharma Live:  Nov 16 2009 8:33PM Matching: calcineurin
Lux Biosciences to Present at Lazard Capital Markets 6th Annual Healthcare Conference
PR inside:  Nov 16 2009 1:31PM Matching: calcineurin
Lux Biosciences to Present at Lazard Capital Markets 6th Annual Healthcare Conference
NewsBlaze:  Nov 16 2009 1:28PM Matching: calcineurin
Lux Biosciences to Present at Lazard Capital Markets 6th Annual Healthcare Conference
Business Wire:  Nov 16 2009 1:05PM Matching: calcineurin
Lux Biosciences to Present at Lazard Capital Markets 6th Annual Healthcare Conference
Yahoo! Canada:  Nov 16 2009 1:05PM Matching: calcineurin
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Calcineurin Patents:

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US Patent No.Title
7544678 Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
7575875 Method of tacrolimus extraction and quantification using aqueous detergents
7576057 Cyclic peptides
7579148 Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases
7579319 Methods for improving the structure and function of arterioles

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BioPortfolio Ltd. offers e-mail and postal lists for Calcineurin scientists - we have details of around 583 individuals working on Calcineurin .


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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org

 

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