Calpain

Calpains are a family of calcium-dependent, non-lysosomal cysteine proteases expressed ubiquitously in mammals and many lower organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit ), and the endogenous calpain-specific inhibitor, calpastatin. (From the Wikpedia article Calpain.)

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Recent Publications on Calpain:
A proteomic study of calpain-3 and its involvement in limb girdle muscular dystrophy type 2a. Limb-girdle muscular dystrophy type 2A is an autosomal recessive disorder...	21st November, 2009	Department of Biochemistry University of Padova, and Venetian Institute of	Cell Calcium. 2009 Nov 17. DOI Direct Link
Phosphorylation of alpha-actinin-4 upon epidermal growth factor (EGF) exposure regulates its interaction with actin. The ubiquitously expressed family of alpha-actinins bridges actin...	19th November, 2009	University of Pittsburgh, United States.	J Biol Chem. 2009 Nov 17. DOI Direct Link
Stress and signaling responses of rat skeletal muscle to brief endurance exercise during hindlimb unloading: a catch-up process for atrophied muscle. At times, exercise accompanied by its anabolic effects is not a tractable...	17th November, 2009	Yonsei University, Wonju, Gangwon-Do, Republic of Korea.	Cell Physiol Biochem. 2009;24(5-6):537-46. Epub 2009 Nov 4. DOI Direct Link
A novel calpain inhibitor, SNJ-1945, reduces murine retinal cell death in vitro and in vivo. We examined whether SNJ-1945, a new orally available calpain inhibitor,...	17th November, 2009	1 Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu	J Pharmacol Exp Ther. 2009 Nov 12. DOI Direct Link
Actin Binding Protein-1 Interacts with WIP to Regulate Growth Factor-induced Dorsal Ruffle Formation. Monitoring Editor: Josephine C. Adams Growth factor stimulation induces...	17th November, 2009	Department of Biomolecular Chemistry, and Departments of Medical	Mol Biol Cell. 2009 Nov 12. DOI Direct Link
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Press Releases About Calpain:
Abbott Reports Double-Digit Sales and Earnings Growth in Fourth Quarter; Confirms Strong Outlook for 2009 Earnings	21st January, 2009	Abbott	ABBOTT PARK, Ill., Jan. 21 /PRNewswire-FirstCall/ -- Abbott (NYSE: ABT) today announced financial results for the fourth quarter ended Dec. 31, 2008. -- Diluted earnings per share,

BioNews Results for Calpain:
AnaSpec, Inc. Introduces SensoLyte 520 Calpain Kit	BioSpace:  Nov 19 2009 9:51PM Matching: calpain
The HSV-2 mutant 'PK induces melanoma oncolysis through nonredundant death programs and associated with autop	Nature:  Oct 13 2009 10:34AM Matching: calpain

Calpain Patents:
US Patent No.	Title
7524828	Immunostimulatory nucleic acid molecules
7566787	Small molecule cyclin D1 ablative agents
7569592	Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
7572580	Promoter variants of the alpha-7 nicotinic acetylcholine receptor
7572606	Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs
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BioPortfolio Ltd. offers e-mail and postal lists for Calpain scientists - we have details of around 483 individuals working on Calpain .