Calpain

Calpains are a family of calcium-dependent, non-lysosomal cysteine proteases expressed ubiquitously in mammals and many lower organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit ), and the endogenous calpain-specific inhibitor, calpastatin. (From the Wikpedia article Calpain.)

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Recent Publications on Calpain:
Modulation of integrin antagonist signaling by ligand binding of the heparin-binding domain of vitronectin to the alphaVbeta3 integrin. The interaction between the arginine glycine and aspartic acid motif (RGD)...	11th July, 2008	Division of Endocrinology, Department of Medicine, University of North	J Cell Biochem. 2008 Jul 9;. DOI Direct Link
Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle. Galectin-4 is a carbohydrate-binding protein belonging to the galectin...	10th July, 2008	Medizinische Klinik m.S. Hepatologie und Gastroenterologie, Campus Virchow	PLoS ONE. 2008 Jul 9;3(7):e2629. DOI Direct Link
Regulation of calcineurin activity in insulin-secreting cells: Stimulation by Hsp90 during glucocorticoid-induced apoptosis. Previously, we described that apoptotic cell death induced by the...	10th July, 2008	Institute of Physiology, University of Tubingen, Gmelinstrasse 5, D-72076	Cell Signal. 2008 Jun 18;. DOI Direct Link
[Inhibition of calpain expression by E-64d in the rat retina subjected to ischemia/reperfusion injury] To investigate the effect of E-64d, a selective inhibitor of calpain, on...	10th July, 2008		Mol Biol (Mosk). 2008 Mar-Apr;42(2):258-64.
Effects of yam and diosgenin on calpain systems in skeletal muscle of ovariectomized rats. OBJECTIVE: Yam or diosgenin (extracted from the root of wild yam) is...	8th July, 2008	Department of Animal Science and Biotechnology, Tunghai University,	Taiwan J Obstet Gynecol. 2008 Jun;47(2):180-6.
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BioNews Results for Calpain:
JCI online early table of contents: July 1, 2008	Genetic Engineering News:  Jul 1 2008 10:47PM Matching: calpain
Calpain Inhibitors Never Forget: Improving Memory In Alzheimer's Disease Mice	Science Daily:  Jul 2 2008 5:48AM Matching: calpain
[Teaching Resource] Physiological and Pathological Actions of Calpains in Glutamatergic Neurons	Science Magazine:  Jun 12 2008 10:43AM Matching: calpain

Calpain Clinical Trials:
Docetaxel and Capecitabine for First Line Treatment of Metastatic Squamous Cell Carcinoma of the Head & Neck	Head and Neck Cancer

Calpain Patents:
US Patent No.	Title
7309468	Protease inhibitor sample collection system
7342024	4-Oxo-1-3-substituted phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors
7342027	1-phenylpiperidin-3-one derivatives and processes for the preparation thereof
7345148	Human G-protein coupled receptor, HGPRBMY29sv1 polypeptides
7351537	Variants of cyan fluorescent protein with improved fluorescent properties
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BioPortfolio Ltd. offers e-mail and postal lists for Calpain scientists - we have details of around 483 individuals working on Calpain .

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