Chloracne

Chloracne is an acne-like eruption of blackheads, cysts, and pustules associated with over-exposure to certain halogenated aromatic compounds, such as chlorinated dioxins and dibenzofurans. The lesions are most frequently found on the cheeks, behind the ears, in the armpits and groin region.The condition was first described in German industrial workers in 1897 by Von Bettman, and was initially believed to be caused by exposure to toxic chlorine . It was only in the mid-1950s that chloracne was associated with aromatic hydrocarbons. The substances that may cause chloracne are now collectively known as chloracnegens.Chloracne is particularly linked to toxic exposure to dioxins — so much so that it is considered a clinical sign of dioxin exposure. The severity and onset of chloracne may follow a typical asymptotic dose-response relationship curve. (From the Wikpedia article Chloracne.)

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Recent Publications on Chloracne:
The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles. The aryl hydrocarbon receptor is a signal regulated transcription factor...	29th September, 2009	Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical	Pharmacol Ther. 2009 Sep 23. DOI Direct Link
Cancer incidence in the population exposed to dioxin after the "Seveso accident": twenty years of follow-up. BACKGROUND: The Seveso, Italy accident in 1976 caused the contamination of...	17th September, 2009	Unit of Epidemiology, Department of Preventive Medicine, Fondazione IRCCS	Environ Health. 2009 Sep 15;8:39. DOI Direct Link
Repression of aryl hydrocarbon receptor transcriptional activity by epidermal growth factor. The aryl hydrocarbon receptor (AHR) mediates most, if not all, of the many...	15th September, 2009	Department of Pathology and Laboratory Medicine, Jonsson Comprehensive	Mol Interv. 2009 Jun;9(3):116-8. DOI Direct Link
Loss of dioxin-receptor expression accelerates wound healing in vivo by a mechanism involving TGFbeta. Delayed wound healing caused by inefficient re-epithelialization...	15th September, 2009	Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias,	J Cell Sci. 2009 Jun 1;122(Pt 11):1823-33. Epub 2009 May 12. DOI Direct Link
Inflammatory and chloracne-like skin lesions in B6C3F1 mice exposed to 3,3',4,4'-tetrachloroazobenzene for 2 years. Exposure to dioxin and dioxin-like compounds (DLCs) has been connected to...	10th September, 2009	Hadassah - Hebrew University Medical Center, Jerusalem 91200, Israel.	Toxicology. 2009 Nov 9;265(1-2):1-9. Epub 2009 Sep 6. DOI Direct Link
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Chloracne Clinical Trials:
Molecular Epidemiology of Dioxin-Related Illness in Seveso

Chloracne Patents:
US Patent No.	Title
5753308	Methods for manufacturing food and beverage containers from inorganic aggregates and polysaccharide, protein, or synthetic organic binders
6025394	Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
6030673	Molded starch-bound containers and other articles having natural and/or synthetic polymer coatings
6090195	Compositions used in manufacturing articles having an inorganically filled organic polymer matrix
6096563	Dual particle immunoassay method and kit
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BioPortfolio Ltd. offers e-mail and postal lists for Chloracne scientists - we have details of around 22 individuals working on Chloracne .