Cholangiocarcinoma

Cholangiocarcinoma is a cancer of the bile ducts, which drain bile from the liver into the small intestine. It is a relatively rare cancer, with an annual incidence of 1–2 cases per 100,000 in the Western world, but rates of cholangiocarcinoma have been rising worldwide over the past several decades. Risk factors for cholangiocarcinoma include primary sclerosing cholangitis , congenital liver malformations, infection with the parasitic liver flukes Opisthorchis viverrini or Clonorchis sinensis, and exposure to Thorotrast , a chemical previously used in medical imaging. The symptoms of cholangiocarcinoma include jaundice, weight loss, and sometimes generalized itching. The disease is diagnosed through a combination of blood tests, imaging, endoscopy, and sometimes surgical exploration.Surgery is the only potentially curative treatment, but most patients have advanced and inoperable disease at the time of diagnosis. After surgery, adjuvant chemotherapy or radiation therapy may be given to increase the chances of cure. Patients with advanced and inoperable cholangiocarcinoma are generally treated with chemotherapy and palliative care measures. Areas of ongoing medical research in cholangiocarcinoma include the use of newer targeted therapies and the use of photodynamic therapy. (From the Wikpedia article Cholangiocarcinoma.)

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Recent Publications on Cholangiocarcinoma:
Biliary Infections: Spectrum of Imaging Findings and Management. Infectious cholangitides encompass a wide spectrum of infectious processes...	21st November, 2009	Departments of Radiology and Gastroenterology, Harvard Medical School and	Radiographics. 2009 November-December;29(7):2059-2080. DOI Direct Link
Preoperative 3D volumetric analysis for liver congestion applied in a patient with hilar cholangiocarcinoma. BACKGROUND AND AIMS: Postoperative hepatic failure preceded by...	20th November, 2009	Department of Surgery, Graduate School of Comprehensive Human Sciences,	Langenbecks Arch Surg. 2009 Nov 19. DOI Direct Link
Choledochoduodenal fistula caused by cholangiocarcinoma of the distal common bile duct. BACKGROUND AND AIMS: Postoperative hepatic failure preceded by...	19th November, 2009	Division of General Surgery, Department of Surgery, Tri-Service General	Endoscopy. 2009 Nov;41(S 02):E319-E320. Epub 2009 Nov 17. DOI Direct Link
Endobiliary Metastasis from Rectal Cancer Mimicking Intrahepatic Cholangiocarcinoma: A Case Report and Review of Literature. PURPOSE: The purpose of this study is to report an unusual case of liver...	19th November, 2009	Department of Surgical Oncology, Cancer Institute (WIA), Annexe Campus,	J Gastrointest Cancer. 2009 Nov 17. DOI Direct Link
L1 Cell Adhesion Molecule Is a Novel Independent Poor Prognostic Factor of Extrahepatic Cholangiocarcinoma. PURPOSE: Cholangiocarcinomas (CC) are associated with poor survival, but...	19th November, 2009	Authors' Affiliations: Department of Pathology and Infection Signaling	Clin Cancer Res. 2009 Nov 17. DOI Direct Link
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Press Releases About Cholangiocarcinoma:
Boston Scientific's SpyGlass(R) Direct Visualization System Featured in Broad Range of Clinical Studies at Upcoming Digestive Disease Week(R)	28th May, 2009	Boston Scientific Corporation	This multi-center cumulative study reports on the use of Holmium-YAG laser lithotripsy with SpyGlass cholangioscopy in the management of difficult intraductal biliary
American Transplant Congress 2009: New Investigator Forum Presents Cutting Edge Research	29th April, 2009	American Transplant Congress 2009	ATC Highlights: State-of-the-Art Address - Rudolf Jaenisch M.D., M.I.T., Boston, MA State-of-the-Art Address - Philip Sharp, Ph.D., M.I.T., Boston, MA "What's Hot, What&apos

BioNews Results for Cholangiocarcinoma:
Identifying The Factors Related To Bile Output And Reduction Of Serum Bilirubin After Percutaneous Transhepatic Biliary Drainage	Medical News Today:  Nov 19 2009 7:51PM Matching: cholangiocarcinoma
Medical News: Identifying The Factors Related To Bile Output And Reduction Of Serum Bilirubin After Percutaneous Transhepatic Biliary Drainage	BioFind:  Nov 19 2009 5:38PM Matching: cholangiocarcinoma
Reduction of serum bilirubin, the hallmark of successful biliary drainage	News-Medical.Net:  Nov 19 2009 9:17AM Matching: cholangiocarcinoma
What relates to the short-term effectiveness of biliary drainage?	Genetic Engineering News:  Nov 18 2009 3:21PM Matching: cholangiocarcinoma
Surgical Management of Infrahilar/Suprapancreatic Cholangiocarcinoma: an Analysis of the Surgical Procedures, Surgical Margins, and Survivals of 77 Patients	MDLinx:  Nov 13 2009 11:06AM Matching: cholangiocarcinoma
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Cholangiocarcinoma Patents:
US Patent No.	Title
7534918	Histone deacetylase inhibitors
7563791	Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
7569384	Albumin fusion proteins
7569568	Cytokine inhibitors
7572618	Polynucleotides encoding novel PCSK9 variants
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