Chymotrypsinogen

Chymotrypsinogen is a precursor of the digestive enzyme chymotrypsin .This molecule is inactive and must be cleaved by trypsin, and then by otherchymotrypsin molecules before it can reach its full activity. Its activity is the conversion of proteins to amino acids. The active site of the chymotrypsinogen is covered by a six amino acid long mask. It is only when this mask is removed - when it enters the lumen of the intestine and comes into contact with chymotrypsin molecules - that the enzyme becomes active. This is a very useful safety feature for a protein digesting enzyme. If it wasn't inactivated in this way it would digest the pancreas where it is produced.Category:Enzymes Cicatrix (From the Wikpedia article Chymotrypsinogen.)

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Recent Publications on Chymotrypsinogen:
High binding capacity surface grafted monolithic columns for cation exchange chromatography of proteins and peptides. Poly(glycidyl methacrylate-co-ethylene methacrylate) monoliths have been...	10th November, 2009	The Molecular Foundry, E. O. Lawrence Berkeley National Laboratory,	J Chromatogr A. 2009 Oct 2;1216(40):6824-30. Epub 2009 Aug 18. DOI Direct Link
Amount of adsorbed albumin loss by dialysis membranes with protein adsorption. Polymethylmethacrylate (PMMA) membrane is the first synthetic polymeric...	7th November, 2009	Department of Materials Science and Engineering, Shonan Institute of	J Artif Organs. 2009;12(3):194-9. Epub 2009 Sep 19. DOI Direct Link
Noncovalent poly(1-vinylpyrrolidone)-based copolymer coating for the separation of basic proteins and lipoproteins by CE. A new simple and fast noncovalent coating method based on...	4th November, 2009	Laboratory of Analytical Chemistry, Department of Chemistry, University of	Electrophoresis. 2009 Nov 2. DOI Direct Link
Proteomic analysis of porcine pancreas development. Porcine pancreas development is not well studied at the molecular level...	31st October, 2009	Aging Research Center, Korea Research Institute of Bioscience and	BMB Rep. 2009 Oct 31;42(10):661-6.
Effects of thermal heterogeneity in hydrophobic interaction chromatography. Manipulating temperature and salt concentration can have a powerful effect...	27th October, 2009	Chemical and Process Engineering Department, Rzeszow University of	J Chromatogr A. 2009 Sep 25;1216(39):6716-27. Epub 2009 Aug 11. DOI Direct Link
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Chymotrypsinogen Patents:
US Patent No.	Title
7227009	MT-SP1 polynucleotides and polypeptides
7326326	System and methods for electrophoretic separation of proteins on protein binding membranes
7329506	Apparatuses and methods for determining protease activity
7329517	Escapin protein, a broadly antimicrobial compound from ink of the sea hare Aplysia californica, and uses thereof
7344881	Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
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BioPortfolio Ltd. offers e-mail and postal lists for Chymotrypsinogen scientists - we have details of around 121 individuals working on Chymotrypsinogen .