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Cryosurgery

Cryosurgery is the application of extreme cold to destroy abnormal or diseased tissue. Cryosurgery comes from the Greek cryo meaning icy cold and the word surgery meaning literally hand work or HandiworkCryosurgery is used to treat a number of diseases and disorders, especially skin conditions. Warts, moles, skin tags, solar keratoses, and small skin cancers are candidates for cryosurgical treatment. Some internal disorders are also treated with cryosurgery, including liver cancer, prostate cancer, cervical disorders and, more commonly in the past, hemorrhoids. Although found to be effective, this method of treatment is only appropriate for use against localized diseases with no metastasis.Cryosurgery works by taking advantage of the destructive force of freezing temperatures on cells. At low temperatures, ice crystals form inside the cells, which can tear them apart. More damage occurs when blood vessels supplying the diseased tissue freeze.In the past, the most common method to freeze was using liquid nitrogen as the cooling solution. The super-cooled liquid may be sprayed on the diseased tissue, circulated through a tube called a cryoprobe, or simply dabbed on with a cotton or foam swab. Less frequently, doctors use carbon dioxide "snow" formed into a cylinder or mixed with acetone to form a slush that is applied directly to the treated tissue. Recent advances in technology have allowed for the use of Argon gas to drive ice formation using a principle known as the Joule-Thomson effect. This gives physicians excellent control of the ice, and minimizing complications using ultra-thin 17 gauge cryoneedles.Cryosurgery is a minimally invasive procedure, and is often preferred to more traditional kinds of surgery because of its minimal pain, scarring, and cost; however, as with any medical treatment, there are risks involved, primarily that of damage to nearby healthy tissue. Damage to nerve tissue is of particular concern.Patients undergoing cryosurgery usually experience minor-to-moderate localized pain and redness, which can be alleviated by oral administration of an analgesic or ibuprofen) and application of topical steroid cream. Blisters may form, but these usually scab over and peel away.Category:Medical treatmentsit:Crioterapia Cryotherapy Cryotherapy is used to define several techniques and procedures in the medical community. The most general definition is the local or general use of low temperatures in medical therapy or the removal of heat from a body part to decrease cellular metabolism, increase cellular survival, decrease inflammation, decrease pain and spasm, promote vasoconstriction, and when using extreme temperatures, to destroy cells by crystalizing the cytosol. It can also be called crymotherapy. The most prominent use of the term refers to the surgical treatment, specifically known as cryosurgery.Other therapies that use the term are cryogenic chamber therapy and ice pack therapy.Cryotherapy is the application of extreme cold to destroy abnormal or diseased tissue. Cryotherapy is used to treat a number of diseases and disorders, especially skin conditions like warts, moles, skin tags and solar keratoses.Liquid nitrogen is usually used to freeze the tissues at the cellular level. The procedure is used often because of its efficacy and low rates of side effects.For more information, see CryosurgeryCryotherapy is a treatment where a person is placed in a cryogenic chamber for a short duration.The chamber is typically cooled with liquid nitrogen to a temperature of –110 C. For more information see Cryotherapy Cryotherapy is commonly used to treat pain conditions. Most forms of cryotherapy used as passive physical modalities of the management and rehabilitation of both acute and persistent pain conditions, provide transfer of thermal energy by conduction, with the exception of vapocoolant sprays and whirlpool baths . The physiologic effects of cold application include immediate vasoconstriction with reflexive vasodilation, decreased local metabolism and enzymatic activity, and decreased oxygen demand. Cold decreases muscle spindle fiber activity and slows nerve conduction velocity, therefore it is often used to decrease spasticity and muscle guarding. (From the Wikpedia article Cryosurgery.)

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Recent Publications on Cryosurgery:

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Proteolytic events in cryonecrotic cell death: proteolytic activation of endonuclease p23.
Although cryosurgery is attaining increasing clinical acceptance, our...
6th February, 2010
Department of Molecular Biology, Institute for Biological Research "Sinisa Cryobiology. 2010 Feb 1.
DOI Direct Link
[Patients who undergo cryoplasty. Nursing results (NOC), tolerance to this operation]
The medical profession has started to use a new treatment for peripheral...
3rd February, 2010
Servicio de Radiologia Vascular Intervencionista, Hospital de Navarra, Rev Enferm. 2009 Oct;32(10):38-42.
New data cheer champions of the danger theory.
BACKGROUND: The low aggressiveness of Grade I chondrosarcomas is...
2nd February, 2010
J Natl Cancer Inst. 2010 Jan 20;102(2):76-8. Epub 2010 Jan 6.
DOI Direct Link
Review of six cases of maxillary ameloblastoma from the West Indies: re-entry cryosurgery as prophylactic surgical intervention.
Maxillary ameloblastoma is a rare histopathological entity. A total of six...
27th January, 2010
Oral Disease Unit, Faculty of Medical Sciences, The University of the West West Indian Med J. 2009 Sep;58(4):398-403.
Argon-helium cryosurgery for treatment of C6 gliomas in rats and its effect on cellular immunity.
Argon-helium cryosurgery has shown encouraging therapeutic effects on some...
20th January, 2010
Department of Neurosurgery, Institute of Neuroscience of Guangdong Technol Cancer Res Treat. 2010 Feb;9(1):87-94.

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Press Releases About Cryosurgery:

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PROFNET EXPERT ALERTS: New Mammogram Guidelines 18th November, 2009
___________ TOPIC ALERT New Mammogram Guidelines (33 responses) _____________ EXPERT ALERTS 1. Law: Challenge of Jackson Estate's Executor Selection May Be Too Late 2. Law: New Law
Health Robotics Reaches 100% Asia-Pacific Coverage Through its New Exclusive Distribution Contract With BioRobotics in Korea 12th November, 2009
BOZEN, SUD-TYROL, Italy, November 12 /PRNewswire/ -- Health Robotics today announced that Innomed/BioRobotics, on the heels of its prior market success with Oncology Surgery robots, has exclusively
New Report Just Published: World Prostate Cancer Therapeutics Market Report 7th July, 2009 Reportlinker
NEW YORK, July 7 /PRNewswire/ -- Reportlinker.com just added a new market research report to its catalogue. World Prostate Cancer Therapeutics Market http://www.reportlinker.com/p0119471/World
ATS Medical Products Featured Prominently in Scientific Presentations at European Association for Cardio-Thoracic Surgeons (EACTS) Annual Meeting 11th September, 2008 ATS Medical, Inc. European Association for Cardio-Thoracic Surgeons
MINNEAPOLIS, Sept. 11 /PRNewswire-FirstCall/ -- ATS Medical, Inc. (Nasdaq: ATSI), manufacturer and marketer of state-of-the-art cardiac surgery products and services, today announced that an

Cryosurgery Clinical Trials:

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Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer

Cryosurgery Patents:

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US Patent No.Title
7476384 Death domain containing receptor 4 antibody and methods
7507235 Method and system for organ positioning and stabilization
7507247 Urethral catheter stent delivery system
7510554 Detachable cryosurgical probe
7514078 Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies

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Companies working in the area of Cryosurgery from Bioportfolio's Biocorporate database :

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Company Name

Brymill Cryogenic Systems

Liquid nitrogen cryosurgery with a cryogun is the coldest (-196º C), most effective, and most versatile cryosurgical technique available. LN2 applied with a cryogun is much colder and therefore more...
www.brymill.com/        View full profile
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BioPortfolio Ltd. offers e-mail and postal lists for Cryosurgery scientists - we have details of around 970 individuals working on Cryosurgery .


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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org

 

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