Recent Publications on Dealkylation: |  |
Sublingual Buprenorphine for Treatment of Neonatal Abstinence Syndrome: A Randomized Trial.
OBJECTIVE. In utero exposure to drugs of abuse can lead to neonatal...
Direct Link | 13th August, 2008
| aDepartments of Pharmacology and Experimental Therapeutics.
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Maraviroc: in vitro assessment of drug-drug interaction potential.
WHAT IS ALREADY KNOWN ABOUT THE SUBJECT * Maraviroc is known to undergo...
Direct Link | 24th July, 2008
| Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and
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Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects.
AIMS: Two studies were conducted to: (i) quantify the amount of...
Direct Link | 24th July, 2008
| Pfizer Global R&D, Sandwich, UK.
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Practical demethylation of aryl methyl ethers using an odorless thiol reagent.
A highly practical method for demethylation of aryl methyl ethers...
Direct Link | 10th July, 2008
| Department of Chemistry and Institute of Basic Sciences, Sungshin Women's
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N-Dealkylation of aliphatic amines and selective synthesis of monoalkylated aryl amines.
Highly selective alkyl transfer processes of mono-, di- and trialkyl...
Direct Link | 3rd July, 2008
| Leibniz-Institut fur Katalyse e.V. an der Universitat Rostock,
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Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials.
The disposition of three 4-aminoquinoline leads, namely isoquine (ISO),...
Direct Link | 20th June, 2008
| Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Drug Discovery, 1250
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Hypercalcemia of Primary Hyperparathyroidism was Treated by Cinacalcet in a Patient with Liver Cirrhosis.
Cinacalcet is a type II calcimimetic agent which is an allosteric...
Direct Link | 19th June, 2008
| 1Division of Endocrinology and Metabolism, Department of Internal
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Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics.
N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-met...
Direct Link | 17th June, 2008
| Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and
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Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
Escherichia coli AlkB and its human homologues ABH2 and ABH3 repair...
Direct Link | 12th June, 2008
| Department of Chemistry, The University of Chicago, 929 East 57th Street,
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Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase.
The high reactivity of cholinesterases (ChEs) toward organophosphorus (OP)...
Direct Link | 5th June, 2008
| Israel Institute for Biological Research, Ness-Ziona 74100, Israel.
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Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2.
Three CYP6Z genes are linked to a major pyrethroid resistance locus in the...
Direct Link | 30th April, 2008
| Biomedical Research Centre, University of Dundee, Ninewells Hospital and
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Evidence that the anticarcinogenic effect of caffeic acid phenethyl ester in the resistant hepatocyte model involves modifications of cytochrome P450.
Caffeic acid phenethyl ester (CAPE), a natural component of propolis,...
Direct Link | 10th April, 2008
| Departamento de Biologia Celular, Centro de Investigacion y de Estudios
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Catalytic function of avian cytochrome P450 1A4 and 1A5 (CYP1A4 and CYP1A5) enzymes heterologously expressed using in vitro yeast system.
The present study clarifies the enzymatic properties of two avian...
Direct Link | 2nd April, 2008
| Division of Ecotoxicology, Center for Marine Environmental Studies, Ehime
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