Deamination

Deamination is the removal of an amine group from a molecule.In the human body, deamination takes place in the liver. It is the process by which amino acids are broken down. The amino group is removed from the amino acid and converted to ammonia. The rest of the amino acid is made up of mostly carbon and hydrogen, and is recycled or oxidized for energy. Ammonia is toxic to the human system, and enzymes convert it to urea or uric acid by addition of carbon dioxide molecules in the urea cycle. Urea and uric acid can safely diffuse into the blood and then be excreted in urine. (From the Wikpedia article Deamination.)

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Recent Publications on Deamination:
Efficient Recognition of an Unpaired Lesion by a DNA Repair Glycosylase. The duplex structure of DNA, with its internal base pairing, protects the...	21st November, 2009	Department of Biological Chemistry, University of Michigan, Ann Arbor,	J Am Chem Soc. 2009 Nov 19. DOI Direct Link
Degradation of fumonisin B(1) by the consecutive action of two bacterial enzymes. Detoxification of the mycotoxin fumonisin B(1) comprises at least two...	20th November, 2009	Department of Biotechnology, University of Natural Resources and Applied	J Biotechnol. 2009 Nov 13. DOI Direct Link
Reactivity of 4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole, structures and magnetic properties of polynuclear and polymeric Mn(ii), Cu(ii) and Cd(ii) complexes. Five new complexes were obtained from solution or hydrothermal reactions...	19th November, 2009	Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of	Dalton Trans. 2009 Dec 14;(46):10284-10295. Epub 2009 Oct 19. DOI Direct Link
The freshwater Amazonian stingray, Potamotrygon motoro, up-regulates glutamine synthetase activity and protein abundance, and accumulates glutamine when exposed to brackish (15 per thousand) water. This study aimed to examine whether the stenohaline freshwater stingray,...	17th November, 2009	Department of Biological Science, National University of Singapore, Kent	J Exp Biol. 2009 Dec;212(Pt 23):3828-36. DOI Direct Link
A single Phe54Tyr substitution improves the catalytic activity and thermostability of Trigonopsis variabilis D-amino acid oxidase. The industrial importance of Trigonopsis variabilis D-amino acid oxidase...	17th November, 2009	Department of Biochemistry, The Chinese University of Hong Kong, Shatin,	N Biotechnol. 2009 Nov 9. DOI Direct Link
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Deamination Patents:
US Patent No.	Title
7553826	Cytarabine monophosphate prodrugs
7572806	PPAR active compounds
7572893	IL-1 antagonist formulations
7572909	Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine
7576111	Substituted oxazolidinones and their use in the field of blood coagulation
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