Deamination

Deamination is the removal of an amine group from a molecule.In the human body, deamination takes place in the liver. It is the process by which amino acids are broken down. The amino group is removed from the amino acid and converted to ammonia. The rest of the amino acid is made up of mostly carbon and hydrogen, and is recycled or oxidized for energy. Ammonia is toxic to the human system, and enzymes convert it to urea or uric acid by addition of carbon dioxide molecules in the urea cycle. Urea and uric acid can safely diffuse into the blood and then be excreted in urine. (From the Wikpedia article Deamination.)

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Recent Publications on Deamination:
Cloning, Protein Sequence Clarification, and Substrate Specificity of a Leucine Dehydrogenase from Bacillus sphaericus ATCC4525. Although an X-ray model sequence of a leucine dehydrogenase from Bacillus...	16th July, 2008	Department of Chemistry, Southern Methodist University, Dallas, TX, 75275,	Appl Biochem Biotechnol. 2008 Jul 15;. DOI Direct Link
PCR-Based Analysis of Differentially Methylated Regions of GNAS Enables Convenient Diagnostic Testing of Pseudohypoparathyroidism Type Ib. BACKGROUND: Pseudohypoparathyroidism type Ib (PHPIb) is characterized by...	12th July, 2008	Austrian Research Centers GmbH-ARC, Molecular Diagnostics, Seibersdorf,	Clin Chem. 2008 Jul 10;. DOI Direct Link
Plant histaminase as an investigational drug in splanchnic artery occlusion and reperfusion. BACKGROUND: Amine oxidases are ubiquitous enzymes involved in the...	12th July, 2008	University of Messina, School of Medicine, Department of Clinical,	Expert Opin Investig Drugs. 2008 Aug;17(8):1151-60. DOI Direct Link
Characterization of Ig gene somatic hypermutation in the absence of activation-induced cytidine deaminase. Somatic hypermutation (SHM) of Ig genes depends upon the deamination of C...	9th July, 2008	Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal	J Immunol. 2008 Jul 15;181(2):1299-306.
Identification of Two Major Ammonia-Releasing Reactions Involved in Secondary Natto Fermentation. Natto is a traditional Japanese food made from soybeans fermented by...	8th July, 2008	Central Research Institute, Mizkan Group Co.	Biosci Biotechnol Biochem. 2008 Jul 7;.
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Deamination Clinical Trials:
A Possible Therapeutic Role for Adenosine During Inflammation	Endotoxemia Interventions: Genetic: AMPD1 polymorphism;   Drug: Caffeine infusion;   Drug: placebo

Deamination Patents:
US Patent No.	Title
7332304	Process and materials for production of glucosamine and N-acetylglucosamine
7351399	Prodrugs for phosphorus-containing compounds
7354591	Poxvirus with targeted infection specificity
7355084	Method for hydrogenating organic compounds by means of Ru/SiO.sub.2 catalysts
7355199	Substituted anthracenes and electronic devices containing the substituted anthracenes
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