Dentigerous Cyst

A dentigerous cyst is an odontogenic cyst - thought to be of developmental origin - associated with the crown of an unerupted tooth. The cyst cavity is lined by epithelial cells derived from the reduced enamel epithelium of the tooth forming organ. Regarding its pathogenesis, it has been suggested that the pressure exerted by an erupting tooth on the follicle may obstruct venous flow inducing accumulation of exudate between the reduced enamel epithelium and the tooth crown.In addition to the developmental origin, some authors have suggested that periapical inflammation of non-vital deciduous teeth in proximity to the follicles of unerupted permanent successors may be a factor for triggering this type of cyst formation.Histologically a normal dental follicle is lined by enamel epithelium, where as dentigerous cyst is lined by non keratinising stratified squamous epithelium. Since the dentigerous cyst develops from follicular epithelium it has more potential for growth, differentiation and degeneration than a radicular cyst. Occasionally the wall of a dentigerous cyst may give rise to a more ominous mucoepidermoid carcinoma. Dentigerous cysts due to its propensity for rapid expansion may cause pathological fractures of jaw bones. The usual radiographic appearance is that of a well-demarcated radiolucent lesion attached at an acute angle to the cervical area of an unerupted tooth. The border of the lesion may be radiopaque. The radiographic differentiation between a dentigerous cyst and a normal dental follicle is based merely on size. While viewing an xray a dentigerous cyst should always be differentiated from a normal dental follicle. In all probability a large sized cyst could only be a dentigerous cyst. Category:Developmental cystsCategory:Oral pathologyzh-min-nan:Hâm-khí lông-chéng Dentinogenesis Dentinogenesis is the formation of dentin, a substance that forms the majority of teeth. Dentinogenesis is performed by odontoblasts, which are a special type of biological cells on the outside of dental pulps, and it begins at the late bell stage of a developing tooth. The different stages of dentin formation result in different types of dentin: mantle dentin, primary dentin, secondary dentin, and tertiary dentin.Odontoblasts differentiate from cells of the dental papilla. They begin secreting an organic matrix around the area directly adjacent to the inner enamel epithelium, closest to the area of the future cusp of a tooth. The organic matrix contains collagen fibers with large diameters . The odontoblasts begin to move toward the center of the tooth, forming an extension called the odontoblast process. Thus, dentin formation proceeds toward the inside of the tooth. The odontoblast process causes the secretion of hydroxyapatite crystals and mineralization of the matrix. This area of mineralization is known as mantle dentin and is a layer usually about 5-30 μm thick.Whereas mantle dentin forms from the preexisting ground substance of the dental papilla, primary dentin forms through a different process. Odontoblasts increase in size, eliminating the availability of any extracellular resources to contribute to an organic matrix for mineralization. Additionally, the larger odontoblasts cause collagen to be secreted in smaller amounts, which results in more tightly arranged, heterogeneous nucleation that is used for mineralization. Other materials are also secreted. Secondary dentin is formed after root formation is finished and occurs at a much slower rate. It is not formed at a uniform rate along the tooth, but instead forms faster along sections closer to the crown of a tooth. This development continues throughout life and accounts for the smaller areas of pulp found in older individuals. Tertiary dentin, also known as reparative dentin, forms in reaction to stimuli, such as attrition or dental caries.The dentin in the root of a tooth forms only after the presence of Hertwig's epithelial root sheath , near the cervical loop of the enamel organ. Root dentin is considered different from dentin found in the crown of the tooth because of the different orientation of collagen fibers, the decrease of phosphoryn levels, and the less amount of mineralization. (From the Wikpedia article Dentigerous Cyst.)

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Recent Publications on Dentigerous Cyst:
Immunohistochemical analysis of a dentigerous cyst in a dog. A dentigerous cyst is a cyst that encloses part or the entire crown of an...	5th November, 2009	Nihon University School of Dentistry at Matsudo, Department of Oral	J Vet Dent. 2009 Summer;26(2):106-9.
Relationship Between the Prevalence of the Dentigerous Cyst and the Odontogenic Keratocyst Tumor and the Current Etiologic Hypothesis. Cysts are considered as nonneoplastic benign lesions that, when present...	3rd November, 2009	From the Department of Diagnosis and Surgery, Araraquara Dental School,	J Craniofac Surg. 2009 Oct 29. DOI Direct Link
Dentigerous cyst associated with an ectopic tooth in the maxillary sinus: a report of 3 cases and review of the literature. Dentigerous cysts are benign odontogenic cysts that are associated with...	31st October, 2009	Associate Professor, Department of Oral and Maxillofacial Surgery,	Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Oct 27. DOI Direct Link
A rare cause of nasolacrimal duct obstruction: dentigerous cyst in the maxillary sinus. The most common abnormality of the lacrimal drainage system is congenital...	29th October, 2009	Department of Ophthalmology and ENT, Khudiram Bose Sarani, R.G. Kar	Indian J Ophthalmol. 2009 Nov-Dec;57(6):465-7. DOI Direct Link
Inverted impaction of a mandibular premolar associated with a dentigerous cyst: report of a case. Inverted impaction of mandibular premolars is reported to be rare; its...	29th October, 2009	Cardiff University, School of Dentistry, Heath Park, Cardiff, UK.	Dent Update. 2009 Jul-Aug;36(6):374-6.
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BioNews Results for Dentigerous Cyst:
Prescribing combined OCs may not be effective for certain ovarian cysts	Modern Medicine:  Nov 21 2009 1:23AM Matching: cyst
Practical Matters: Increase your ability to detect pulmonary metastases	Thomson Veterinary Healthcare Communications:  Nov 20 2009 12:03PM Matching: cyst
One Out of 100 Nigerian Women Proned to Ovarian Cancer - Dr. Oye-Adeniran	AllAfrica.com:  Nov 18 2009 3:54PM Matching: cyst
Innominate artery cannulation for congenital heart disease	Bioscience Technology Online:  Nov 18 2009 9:39AM Matching: cyst
Infection after endoscopic ultrasound-guided aspiration of mediastinal cysts	Bioscience Technology Online:  Nov 18 2009 9:39AM Matching: cyst
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Dentigerous Cyst Patents:
US Patent No.	Title
7232667	Keratinocyte growth factor-2 polynucleotides
6693077	Keratinocyte growth factor-2

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