Diphtheria

Diphtheria — “pair of leather scrollsâ€Â�), is an upper respiratory tract illness characterized by sore throat, low fever, and an adherent membrane on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, a facultatively anaerobic Gram-positive bacterium.Diphtheria is a highly contagious disease spread by direct physical contact or breathing the aerosolized secretions of infected individuals. Once quite common, diphtheria has largely been eradicated in developed nations through wide-spread vaccination. In the United States for instance, between 1980 and 2004 there have been 57 reported cases of diphtheria as the DPT vaccine is given to all school children. Boosters of the vaccine are recommended for adults since the benefits of the vaccine decrease with age; they are particularly recommended for those traveling to areas where the disease has not been eradicated. (From the Wikpedia article Diphtheria.)

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Recent Publications on Diphtheria:
Cutting Edge: Depletion of Foxp3+ Cells Leads to Induction of Autoimmunity by Specific Ablation of Regulatory T Cells in Genetically Targeted Mice1. We have recently described two independent mouse models in which the...	20th November, 2009	*Department of Immunology, University of Washington, Seattle, WA 98195;	J Immunol. 2009 Nov 18. DOI Direct Link
Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells. Mucosal vaccination via the respiratory tract can elicit protective...	18th November, 2009	Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany.	J Exp Med. 2009 Nov 16. DOI Direct Link
Expression of IL-13Ralpha2 in liver cancer cells and its effect on targeted therapy of liver cancer. PURPOSE: Liver cancer is the third leading cause of cancer-related deaths...	17th November, 2009	College of Life Sciences and Bioengineering, Beijing Jiaotong University,	J Cancer Res Clin Oncol. 2009 Nov 15. DOI Direct Link
[Production and characteristics of monoclonal antibodies to the diphtheria toxin.] Monoclonal antibodies to the diphtheria toxin were produced without cross...	17th November, 2009	Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy	Bioorg Khim. 2009 Sep-Oct;35(5):618-28.
Pertussis immunity and response to tetanus-reduced diphtheria-reduced pertussis vaccine (Tdap) after autologous peripheral blood stem cell transplantation. Pertussis is a highly contagious respiratory infection characterized by...	10th November, 2009	Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New	Biol Blood Marrow Transplant. 2009 Dec;15(12):1538-42. Epub 2009 Sep 25. DOI Direct Link
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Press Releases About Diphtheria:
MinuteClinic Opens First Retail Clinic in Washington, D.C. at CVS/pharmacy Store in Northeast	24th November, 2009	MinuteClinic	WASHINGTON, Nov. 24 /PRNewswire/ -- MinuteClinic, the pioneer and largest provider of retail-based health care in the United States, has opened its first retail health care center in Washington, D.C.
Sanofi Pasteur Presents Safety Data on Menactra(R) Vaccine Given to Infants at Infectious Disease Society Meeting	2nd November, 2009	Sanofi Pasteur	PHILADELPHIA, Nov. 2 /PRNewswire/ -- Sanofi Pasteur, the vaccines division of sanofi-aventis Group (EURONEXT: SAN and NYSE: SNY), presented Safety of a Quadrivalent (A,C,Y,W-135) Meningococcal Vaccine
Sanofi Pasteur Responds to Nation's Need for Hib Vaccine With Increased Supply	25th June, 2009	Sanofi Pasteur	- The CDC Reinstates Booster Dose of Hib Vaccine - SWIFTWATER, Pa., June 25 /PRNewswire/ -- Sanofi Pasteur, the vaccines division of the sanofi-aventis Group (EURONEXT: SAN and NYSE: SNY), announced
FDA Grants Priority Review Status to Prevnar 13 Marketing Application	7th May, 2009		COLLEGEVILLE, Pennsylvania, May 7 /PRNewswire/ -- -- Candidate vaccine designed to protect against the 13 most prevalent serotypes associated with pneumococcal disease -- Wyeth Pharmaceuticals,
Wyeth Submits Marketing Application to FDA for its 13-Valent Vaccine for the Prevention of Pneumococcal Disease in Infants and Toddlers	31st March, 2009		COLLEGEVILLE, Pennsylvania, March 31 /PRNewswire/ -- Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), announced today that it has submitted a Biologic License Application (BLA) to the U.S. Food

BioNews Results for Diphtheria:
FDA Advisory Committee Finds Data Support the Safety and Effectiveness of Prevnar 13„ Vaccine for the	PharmaceuticalProcessing:  Nov 20 2009 8:26PM Matching: diphtheria
FDA Advisory Committee Finds Data Support The Safety And Effectiveness Of Prevnar 13 Vaccine For The Preventio	Medical News Today:  Nov 20 2009 4:20AM Matching: diphtheria
News and FDA Updates for Tongjitang (NYSE:TCM), YM BioSciences (NYSE:YMI), Pfizer (NYSE:PFE)	California Chronicle:  Nov 20 2009 4:44AM Matching: diphtheria
News and FDA Updates for Tongjitang (NYSE:TCM), YM BioSciences (NYSE:YMI), Pfizer (NYSE:PFE)	American Chronicle:  Nov 20 2009 1:10AM Matching: diphtheria
FDA Advisory Committee Finds Data Support the Safety and Effectiveness of Pfizer Inc. (PFE)'s (JOBS) Prevnar 1	BioSpace:  Nov 19 2009 9:51PM Matching: diphtheria
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Diphtheria Patents:
US Patent No.	Title
7605235	Anti-tissue factor antibodies and compositions
7608694	Antibody molecules having specificity for human IL-1.beta.
7608750	Nonhuman model animal unresponsive to immunopotentiating synthetic compound
7611699	Methods of using cytokine zalpha11 ligand
7611704	Compositions and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids
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Companies working in the area of Diphtheria from Bioportfolio's Biocorporate database :
Company Name
List Biological Laboratories Incorporated Bacterial toxins for research including cholera, pertussis, tetanus, diphtheria, pasteurella multocida, shiga-like and botulinum toxins are among the products offered by List Labs. Toxin subunits,... www.biolog.com/        View full profile
Paul-Ehrlich-Institut The Paul-Ehrlich-Institut was founded on 1st June 1896 as Institut für Serumforschung und Serumprüfung (Institute for Serum Research and Serum Testing) at Steglitz near Berlin as a test and research... www.pei.de/        View full profile

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