Epispadias

An epispadias is a rare type of malformation of the penis in which the urethra ends in an opening on the upper aspect of the penis. An epispadias is an uncommon and partial form of a spectrum of failures of abdominal and pelvic fusion in the first months of embryogenesis. Most cases involve more severe defects, including a small and bifid phallus with bladder exstrophy or even cloacal exstrophy involving the entire perineum. Despite the similarity of name, an epispadias is not a type of hypospadias, and involves a problem with a different set of embryologic processes. The cause of this defect of early embryogenesis is unknown but does not involve androgens.Women can also have this type of congenital malformation. Epispadias of the female may occur when the urethra develops too far anteriorly, exiting in the clitoris or even more forward. For females, this may not cause difficulty in urination but may cause problems with sexual satisfaction. Frequently, the clitoris is bifurcated at the site of urethral exit, and therefore clitoral sensation is less intense during sexual intercourse due to frequent stimulation during urination. However, with proper stimulation, using either manual or positional techniques, clitoral orgasm is definitely possible and quite pleasurable. Category:Diseasesnl:Epispadiepl:Wierzchniactwouk:Епіспадія Epistaxis (From the Wikpedia article Epispadias.)

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Recent Publications on Epispadias:
Female epispadias. Female epispadias without exstrophy is a rare malformation occurring in 1...	5th November, 2009	Department of Paediatrics, Unit-2, Civil Hospital, Karachi.	J Pak Med Assoc. 2009 May;59(5):314-6.
The Exstrophy-epispadias complex. ABSTRACT: Exstrophy-epispadias complex (EEC) represents a spectrum of...	3rd November, 2009		Orphanet J Rare Dis. 2009 Oct 30;4(1):23. DOI Direct Link
Editorial comment. Isolated female epispadias without exstrophy is an extremely rare...	30th October, 2009		J Urol. 2009 Oct;182(4 Suppl):1812; discussion 1812. Epub 2009 Aug 18. DOI Direct Link
Female epispadias management: perineal urethrocervicoplasty versus classical Young-Dees procedure. PURPOSE: We compared the functional results of 1-stage perineal...	30th October, 2009	Department of Pediatric Surgery and Urology, Assistance Publique-Hopitaux	J Urol. 2009 Oct;182(4 Suppl):1807-11. Epub 2009 Aug 18. DOI Direct Link
Female epispadias: a case report and review of the literature. Isolated female epispadias without exstrophy is an extremely rare...	28th October, 2009	Department of Urology, Medical Faculty, Gaziosmanpasa University, Tokat,	Kaohsiung J Med Sci. 2009 Nov;25(11):613-6.
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Epispadias Clinical Trials:
Muscle Derived Cell Therapy for Bladder Exstrophy Epispadias Induced Incontinence

Epispadias Patents:
US Patent No.	Title
7592010	Albumin fusion proteins
7026447	53 human secreted proteins
6994857	Albumin fusion proteins
6951924	Antibodies against secreted protein HTEBYII
6946134	Albumin fusion proteins
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