Epispadias

An epispadias is a rare type of malformation of the penis in which the urethra ends in an opening on the upper aspect of the penis. An epispadias is an uncommon and partial form of a spectrum of failures of abdominal and pelvic fusion in the first months of embryogenesis. Most cases involve more severe defects, including a small and bifid phallus with bladder exstrophy or even cloacal exstrophy involving the entire perineum. Despite the similarity of name, an epispadias is not a type of hypospadias, and involves a problem with a different set of embryologic processes. The cause of this defect of early embryogenesis is unknown but does not involve androgens.Women can also have this type of congenital malformation. Epispadias of the female may occur when the urethra develops too far anteriorly, exiting in the clitoris or even more forward. For females, this may not cause difficulty in urination but may cause problems with sexual satisfaction. Frequently, the clitoris is bifurcated at the site of urethral exit, and therefore clitoral sensation is less intense during sexual intercourse due to frequent stimulation during urination. However, with proper stimulation, using either manual or positional techniques, clitoral orgasm is definitely possible and quite pleasurable. Category:Diseasesnl:Epispadiepl:Wierzchniactwouk:Епіспадія Epistaxis (From the Wikpedia article Epispadias.)

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Recent Publications on Epispadias:
Management of bladder exstrophy epispadias complex in adults: is abdominal closure possible without osteotomy? PURPOSE: Presentation of bladder exstrophy epispadias complex (BEEC)...	12th June, 2009	Urology and Nephrology Center, Faculty of Medicine, Mansoura University,	World J Urol. 2009 Jun 11. DOI Direct Link
Bladder exstrophy in adulthood. BACKGROUND: We report our experience with the treatment of classic...	27th May, 2009	Department of Urology, KLES Kidney Foundation, KLES Prabhakar Kore	Indian J Urol. 2008 Apr;24(2):164-8.
[Reconstructive surgery of penile deformities and tissue deficiencies] Penile deformities and tissue deficiencies can disturb sexual intercourse...	26th May, 2009	Semmelweis Egyetem, Altalanos Orvostudomanyi Kar, Urologiai Klinika es	Orv Hetil. 2009 May 31;150(22):1023-9. DOI Direct Link
Female epispadias. Female epispadias without exstrophy is a rare malformation occurring in 1...	15th May, 2009	Department of Paediatrics, Unit-2, Civil Hospital, Karachi.	J Pak Med Assoc. 2009 May;59(5):314-6.
Bladder exstrophy masquerading as a pelvic fracture. Bladder exstrophy-epispadias complex is a rare spectrum of congenital...	29th April, 2009	Department of Orthopedics B, Sourasky Medical Center, 6 Weitzman St, Tel	Orthopedics. 2009 Jan;32(1):57.
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Epispadias Clinical Trials:
Dexmedetomidine Infusion in Hypospadias Surgery

Epispadias Patents:
US Patent No.	Title
7521424	Albumin fusion proteins
6994857	Albumin fusion proteins
6951924	Antibodies against secreted protein HTEBYII
6946134	Albumin fusion proteins
6926898	Albumin fusion proteins
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