Erythromelalgia

Erythromelalgia, also known as Mitchell's disease , red neuralgia, or erythermalgia, is a rare disorder in which blood vessels, usually in the lower extremities, are episodically blocked and inflamed. There is severe burning pain and skin redness associated with this blood vessel blockage. The attacks are periodic and are commonly triggered by heat, alcohol consumption, or exertion. Erythromelalgia can occur either as a primary or secondary disorder . Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, hypercholesterolemia, mushroom or mercury poisoning, and some autoimmune disorders. Primary erythromelalgia is caused by mutation of the voltage-gated sodium channel α-subunit gene SCN9A. (From the Wikpedia article Erythromelalgia.)

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Recent Publications on Erythromelalgia:
A novel Na(v)1.7 mutation producing carbamazepine-responsive erythromelalgia. OBJECTIVE: Human and animal studies have shown that Na(v)1.7 sodium...	27th June, 2009	Department of Neurology, Yale University School of Medicine, New Haven.	Ann Neurol. 2009 Mar 23;65(6):733-741. DOI Direct Link
Treatment with carbamazepine and gabapentin of a patient with primary erythermalgia (erythromelalgia) identified to have a mutation in the SCN9A gene, encoding a voltage-gated sodium channel. Summary Primary erythermalgia (erythromelalgia) is a rare autosomal...	25th June, 2009	Department of Dermatology, St George's Hospital, London, UK.	Clin Exp Dermatol. 2009 Jun 17. DOI Direct Link
Red ear syndrome and auricular erythromelalgia: the same condition? Several cases of relapsing attacks during which the ear becomes red and...	6th June, 2009	Department of Dermatology, J.W. Goethe-University, Frankfurt, Germany.	Clin Exp Dermatol. 2009 Jun 1. DOI Direct Link
Genetics and molecular pathophysiology of Na(v)1.7-related pain syndromes. SCN9A, the gene which encodes voltage-gated sodium channel Na(v)1.7, is...	6th June, 2009	Department of Neurology, Yale University School of Medicine, New Haven,	Adv Genet. 2008;63:85-110. DOI Direct Link
Romiplostim-induced erythromelalgia in a patient with idiopathic thrombocytopenic purpura. Several cases of relapsing attacks during which the ear becomes red and...	3rd June, 2009	Service de Dermatologie, Hopital Saint-Eloi, CHU de Montpellier, 80 avenue	Br J Dermatol. 2009 May 26. DOI Direct Link
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Erythromelalgia Patents:
US Patent No.	Title
7345148	Human G-protein coupled receptor, HGPRBMY29sv1 polypeptides
7390637	Keratinocyte derived interferon
7393662	Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
7393934	Human G-protein chemokine receptor (CCR5) HDGNR10
7402312	Antibodies to vascular endothelial growth factor 2 (VEGF-2)
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BioPortfolio Ltd. offers e-mail and postal lists for Erythromelalgia scientists - we have details of around 44 individuals working on Erythromelalgia .