Erythromelalgia

Erythromelalgia, also known as Mitchell's disease , red neuralgia, or erythermalgia, is a rare disorder in which blood vessels, usually in the lower extremities, are episodically blocked and inflamed. There is severe burning pain and skin redness associated with this blood vessel blockage. The attacks are periodic and are commonly triggered by heat, alcohol consumption, or exertion. Erythromelalgia can occur either as a primary or secondary disorder . Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, hypercholesterolemia, mushroom or mercury poisoning, and some autoimmune disorders. Primary erythromelalgia is caused by mutation of the voltage-gated sodium channel α-subunit gene SCN9A. (From the Wikpedia article Erythromelalgia.)

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Recent Publications on Erythromelalgia:
Voltage-gated sodium channels: therapeutic targets for pain. OBJECTIVE: To provide an overview of the role of voltage-gated sodium...	13th October, 2009	Department of Neurology and Center for Neuroscience and Regeneration	Pain Med. 2009 Oct;10(7):1260-9. DOI Direct Link
Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials. Erythromelalgia (also termed erythermalgia) is a neuropathic pain...	6th October, 2009	Department of Neurology, Yale University School of Medicine, New Haven, CT	Biochem Biophys Res Commun. 2009 Dec 11;390(2):319-24. Epub 2009 Oct 1. DOI Direct Link
Experience with oral mexiletine in primary erythromelalgia in children. Primary erythromelalgia is characterized by burning pain, redness, and...	10th September, 2009	Department of Pediatrics and Neonatology, Sher-i-Kashmir Institute of	Ann Saudi Med. 2009 Jul-Aug;29(4):316-8.
Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation. Inherited erythromelalgia (IEM), an autosomal dominant disorder...	10th September, 2009	Department of Neurology, LCI 707, Yale University School of Medicine, 333	Brain. 2009 Jul;132(Pt 7):1711-22. Epub 2009 Apr 15. DOI Direct Link
A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia. OBJECTIVE: Human and animal studies have shown that Na(v)1.7 sodium...	13th August, 2009	Department of Neurology, Yale University School of Medicine, New Haven, CT	Ann Neurol. 2009 Jun;65(6):733-41. DOI Direct Link
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Erythromelalgia Patents:
US Patent No.	Title
7371825	Anti-MCP-1 antibodies, compositions, methods and uses
7452538	Death domain containing receptor 4 antibodies and methods
7456256	BGS 4
7456288	Heterocyclic compounds and methods of making and using thereof
7459531	50 Human secreted proteins
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BioPortfolio Ltd. offers e-mail and postal lists for Erythromelalgia scientists - we have details of around 44 individuals working on Erythromelalgia .