Recent Publications on Factor Ixa: |  |
Protein S down-regulates factor Xase activity independent of activated protein C: specific binding of factor VIII(a) to protein S inhibits interactions with factor IXa.
Protein S functions as an activated protein C (APC)-independent...
Direct Link | 2nd September, 2008
| Department of Paediatrics, Nara Medical University, Kashihara, Nara,
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Effects of apoptosis and lipid peroxidation on T-lymphoblastoid phospholipid-dependent procoagulant activity.
BACKGROUND: Coagulation has an absolute requirement for macromolecular...
Direct Link | 14th August, 2008
| Biotherapeutics Group, National Institute for Biological Standards and
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Protamine inhibits formation of the covalent factor IXa-anti-thrombin complex.
The effect of protamine sulfate upon the covalent interaction of human...
Direct Link | 8th August, 2008
| Department of Chemistry, Bowling Green State University, Bowling Green,
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Influence of nanometric holes on the sensitivity of a waveguide-mode sensor: label-free nanosensor for the analysis of RNA aptamer-ligand interactions.
Evanescent-field-coupled (EFC) waveguide-mode sensors can be used to...
Direct Link | 5th August, 2008
| Center for Applied Near Field Optics Research (CAN-FOR), National
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The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis.
The role of the factor IXa heparin-binding exosite in coagulation was...
Direct Link | 24th July, 2008
| Dept. of Medicine, University of Wisconsin-Madison, Madison, Wisconsin,
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Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease.
BACKGROUND: Whether selective factor IXa inhibition produces an...
Direct Link | 24th July, 2008
| Duke Clinical Research Institute, 2400 Pratt St, Terrace Level Room 0311,
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Characterization of an ideal amphipathic peptide as a procoagulant agent.
On the basis of previous evidence that amphipathic helical peptides...
Direct Link | 17th July, 2008
| Lady Davis Institute for Medical Research, Jewish General Hospital, McGill
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A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor.
BACKGROUND: Active and safe reversibility of anticoagulation is an unmet...
Direct Link | 9th July, 2008
| Duke Clinical Research Institute, Durham, NC 27705, USA.
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Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain.
Factor VIII is activated and inactivated by plasmin by limited...
Direct Link | 3rd July, 2008
| Department of Pediatrics, Nara Medical University, Kashihara, Nara
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Mild/moderate haemophilia A: new insights into molecular mechanisms and inhibitor development.
In mild/moderate haemophilia A (MHA) patients, many factor VIII (FVIII)...
Direct Link | 25th June, 2008
| Centre de traitement pour Hemophiles AP-HP Hopital Bicetre, Universite
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Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: an exploratory study.
BACKGROUND: Inhibitors of factor (F) IXa show potent antithrombotic...
Direct Link | 18th June, 2008
| Sahlgrenska University Hospital/Ostra, Goteborg, Sweden.
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Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex.
Factor VIII is a procofactor that plays a critical role in blood...
Direct Link | 17th June, 2008
| Marine Biological Laboratory, Woods Hole, MA 02543, USA.
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Identification of 31 novel mutations in the F8 gene in Spanish hemophilia A patients: structural analysis of 20 missense mutations suggests new intermolecular binding sites.
Hemophilia A (HA) is an X-linked bleeding disorder caused by a wide...
Direct Link | 16th May, 2008
| Department of Genetics and Centro de Investigacion Biomedica en Red de
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Enhancement of the enzymatic activity of activated coagulation factor IX by anti-factor IX antibodies.
BACKGROUND: Factor VIIIa (FVIIIa) binds to activated FIX and enhances the...
Direct Link | 2nd May, 2008
| Baxter BioScience, Department of Discovery Research and Technical
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Ixolaris binding to factor X reveals a precursor state of factor Xa heparin-binding exosite.
Ixolaris is a two-Kunitz tick salivary gland tissue factor pathway...
Direct Link | 7th March, 2008
| Instituto de Bioquimica Medica, Centro de Ciencias de Saude, Universidade
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