Recent Publications on Factor Xia: |  |
The elusive physiologic role of Factor XII.
Physiologic hemostasis upon injury involves many plasma proteins in a...
Direct Link | 30th August, 2008
| Division of Hematology and Oncology, Case Western Reserve University and
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Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa.
Coagulation factor XI (FXI) is a covalent homodimer consisting of two...
Direct Link | 20th August, 2008
| Sol Sherry Thrombosis Research Center, Temple University School of
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Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.
Protein Z (PZ) is a plasma vitamin K-dependent protein that functions as a...
Direct Link | 11th July, 2008
| Division of Hematology, Washington University, St Louis, MO, USA.
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Clavatadine A, A natural product with selective recognition and irreversible inhibition of factor XIa.
Bioassay-guided fractionation of a CH2Cl2/MeOH extract of the sponge...
Direct Link | 31st May, 2008
| Eskitis Institute, Griffith University, Brisbane, Queensland 4111,
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A catalytic domain exosite (Cys527-Cys542) in factor XIa mediates binding to a site on activated platelets.
The zymogen, factor XI, and the enzyme, factor XIa, interact specifically...
Direct Link | 31st May, 2008
| Sol Sherry Thrombosis Research Center and Department of Biochemistry,
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Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation.
Factor XI is the zymogen of a dimeric plasma protease, factor XIa, with...
Direct Link | 21st May, 2008
| Department of Pathology, Vanderbilt University, Nashville, Tennessee
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A renaissance for the contact system in blood coagulation?
Protein Z (PZ) is a plasma vitamin K-dependent protein that functions as a...
Direct Link | 16th May, 2008
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Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa.
In serine proteases, Gly193 (chymotrypsin numbering) is conserved with...
Direct Link | 21st March, 2008
| UCLA/Orthopaedic Hospital, Department of Orthopaedic Surgery and Molecular
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| Plasma cholesteryl ester transfer protein and blood coagulability.
| 27th February, 2008
| Dept. of Molecular and Experimental Medicine, The Scripps Research
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Factor XIa and tissue factor activity in patients with coronary artery disease.
It has been established that inflammation and enhanced pro-coagulant...
Direct Link | 22nd February, 2008
| University of Vermont, Department of Biochemistry, Burlington, Vermont,
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The role of tissue factor pathway inhibitor-2 in cancer biology.
Tissue factor pathway inhibitor-2 (TFPI-2), a member of the Kunitz-type...
Direct Link | 23rd January, 2008
| Department of Oncology, Medical University, Bialystok, Poland.
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Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats.
The effect of inhibiting activated blood coagulation factor XIa was...
Direct Link | 6th December, 2007
| Discovery Biology, Bristol-Myers Squibb Company, Pennington, New Jersey
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| Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa. 10781579
| 9th November, 2007
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Macromolecular substrate-binding exosites on both the heavy and light chains of factor XIa mediate the formation of the Michaelis complex required for factor IX-activation.
Binding of factor IX (FIX) to an exosite on the heavy chain of factor XIa...
Direct Link | 27th September, 2007
| Sol Sherry Thrombosis Research Center, Temple University School of
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Functions of AAV-CMV-F.IX And AAV-EF1alpha-F.IX in gene therapy for hemophilia B.
There has been substantial progress in using gene therapy to treat animals...
Direct Link | 17th April, 2007
| Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn
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