Farnesyl-Diphosphate Farnesyltransferase

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Recent Publications on Farnesyl-Diphosphate Farnesyltransferase:
Cloning, solubilization, and characterization of squalene synthase from Thermosynechococcus elongatus BP-1. Squalene synthase (SQS) is a bifunctional enzyme that catalyzes the...	4th July, 2008	Department of Chemistry, University of Utah, 315 South 1400 East, Salt	J Bacteriol. 2008 Jun;190(11):3808-16. Epub 2008 Mar 28. DOI Direct Link
Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase. Saccharomyces cerevisiae utilizes several regulatory mechanisms to...	28th June, 2008	Department of Chemical Engineering, University of California, Berkeley,	Biotechnol Bioeng. 2008 Jun 1;100(2):371-8. DOI Direct Link
The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. In humans, the brain represents only about 2% of the body's mass but...	24th June, 2008	Institute of Mass Spectrometry, School of Medicine, Swansea University,	J Proteome Res. 2008 Apr;7(4):1606-14. Epub 2008 Feb 28. DOI Direct Link
Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation. Niemann-Pick C disease (NPC) is a fatal, neurovisceral genetic disorder....	3rd June, 2008	Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755,	J Neurosci Methods. 2008 Feb 15;168(1):15-25. Epub 2007 Sep 12. DOI Direct Link
Human cholesterol metabolism and therapeutic molecules. There has been a fascinating interplay between the discovery of some of...	29th March, 2008	Cardiovascular Research Group, School of Clinical & Laboratory Sciences,	Exp Physiol. 2008 Jan;93(1):27-42. DOI Direct Link
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Farnesyl-Diphosphate Farnesyltransferase Clinical Trials:
Tipifarnib Versus Best Supportive Care in the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML)	Myeloid Leukemia;   Acute Disease
Letrozole With or Without Tipifarnib in Treating Women With Locally Advanced, Locally Recurrent, or Metastatic Breast Cancer	Breast Cancer
Tipifarnib in Preventing Cancer in Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas	Neurofibromatosis Type 1 (nf1);   Precancerous/Nonmalignant Condition;   Sarcoma
BMS-214662 in Treating Patients With Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myeloid Leukemia	Leukemia;   Myelodysplastic Syndromes
Study of ZARNESTRA™ as Postconsolidation Therapy for Acute Myeloid Leukemia in Subjects 60 Years & Older	Acute Myeloid Leukemia
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Farnesyl-Diphosphate Farnesyltransferase Patents:
US Patent No.	Title
7329422	Pharmaceutical compositions
7276593	Proteins and nucleic acids encoding same
7235358	Methods and compositions for diagnosing and monitoring transplant rejection
7026121	Methods and compositions for diagnosing and monitoring transplant rejection
6905827	Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
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