Recent Publications on Farnesyl-Diphosphate Farnesyltransferase: |  |
Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous lesions.
BACKGROUND AND PURPOSE: Inhibition of squalene synthesis could transform...
Direct Link | 3rd October, 2008
| Institute for Experimental Animals, Kobe University School of Medicine,
|
Arabidopsis thaliana contains a single gene encoding squalene synthase.
Squalene synthase (SQS) catalyzes the condensation of two molecules of...
Direct Link | 19th September, 2008
| Departament de Bioquimica i Biologia Molecular, Facultat de Farmacia,
|
Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics.
BACKGROUND AND PURPOSE: Inhibition of squalene synthesis could transform...
Direct Link | 30th August, 2008
| Department of Biological Chemistry and Molecular Pharmacology, Harvard
|
K45R variant of squalene synthase increases total cholesterol levels in two study samples from a French Canadian population.
Squalene synthase is an important component of the cholesterol...
Direct Link | 22nd August, 2008
| Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
|
Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.
Cholesterol metabolism is deregulated in carcinogenesis, and cancer cells...
Direct Link | 6th August, 2008
| Liver Unit and Centro de Investigaciones Biomedicas Esther Koplowitz,
|
Genetics and molecular biology: a cholesterol-lowering drug with antibacterial properties.
BACKGROUND: Lapaquistat was the only squalene synthase inhibitor in Phase...
Direct Link | 6th August, 2008
|
|
Emerging lipid-lowering drugs: squalene synthase inhibitors.
BACKGROUND: Lapaquistat was the only squalene synthase inhibitor in Phase...
Direct Link | 5th August, 2008
| University of Louisiana at Monroe, Department of Clinical and
|
Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis.
The destiny and activity of sterol regulatory element-binding proteins...
Direct Link | 18th July, 2008
| Department of Applied Biological Chemistry, Graduate School of
|
Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver.
Mice were subjected to different dietary manipulations to selectively...
Direct Link | 17th July, 2008
| Department of Molecular Biology and Biochemistry, School of Biological
|
Removing the golden coat of Staphylococcus aureus.
Farmer''s lung incidence in Ireland was constant until 1996, even though...
Direct Link | 9th July, 2008
| Department of Pediatrics, Section of Infectious Diseases, University of
|
Cloning, solubilization, and characterization of squalene synthase from Thermosynechococcus elongatus BP-1.
Squalene synthase (SQS) is a bifunctional enzyme that catalyzes the...
Direct Link | 4th July, 2008
| Department of Chemistry, University of Utah, 315 South 1400 East, Salt
|
Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase.
Saccharomyces cerevisiae utilizes several regulatory mechanisms to...
Direct Link | 28th June, 2008
| Department of Chemical Engineering, University of California, Berkeley,
|
The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome.
In humans, the brain represents only about 2% of the body's mass but...
Direct Link | 24th June, 2008
| Institute of Mass Spectrometry, School of Medicine, Swansea University,
|
| Isolation and structural determination of squalene synthase inhibitor from Prunus mume fruit.
| 26th March, 2008
| Department of Food and Culinary Art, Osan College, Osan 447-749, Korea.
|
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.
Staphylococcus aureus produces hospital- and community-acquired...
Direct Link | 22nd March, 2008
| Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 11529,
|
