Farnesyltranstransferase

In enzymology, a farnesyltranstransferase is an enzyme that catalyzes the chemical reaction:trans,trans-farnesyl diphosphate + isopentenyl diphosphate $ightleftharpoons$ diphosphate + geranylgeranyl diphosphateThus, the two substrates of this enzyme are trans,trans-farnesyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and geranylgeranyl diphosphate.This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase. Other names in common use include geranylgeranyl-diphosphate synthase, geranylgeranyl pyrophosphate synthetase, geranylgeranyl-PP synthetase, farnesyltransferase, and geranylgeranyl pyrophosphate synthase. This enzyme participates in biosynthesis of steroids and terpenoid biosynthesis. (From the Wikpedia article Farnesyltranstransferase.)

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Recent Publications on Farnesyltranstransferase:
ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders. ZMPSTE24 is an integral membrane zinc metalloprotease originally...	3rd November, 2009	Department of Cell Biology, The Johns Hopkins University School of	Biol Chem. 2009 Aug;390(8):761-73. DOI Direct Link
Overproduction of geranylgeraniol by metabolically engineered Saccharomyces cerevisiae. (E, E, E)-Geranylgeraniol (GGOH) is a valuable starting material for...	23rd October, 2009	Biotechnology Laboratory, Toyota Central R&D Laboratories, Inc., Nagakute,	Appl Environ Microbiol. 2009 Sep;75(17):5536-43. Epub 2009 Jul 10. DOI Direct Link
3D-QSAR with the aid of pharmacophore search and docking-based alignments for farnesyltransferase inhibitors. Farnesyltransferase is a potential drug target for treating various types...	15th October, 2009	Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121	Eur J Med Chem. 2009 Oct;44(10):4070-82. Epub 2009 May 8. DOI Direct Link
Farnesylation of pex19p is required for its structural integrity and function in peroxisome biogenesis. The conserved CaaX box peroxin Pex19p is known to be modified by...	15th October, 2009	Department for Systems Biochemistry, Institute for Physiological	J Biol Chem. 2009 Jul 31;284(31):20885-96. Epub 2009 May 18. DOI Direct Link
The posttranslational processing of prelamin A and disease. Human geneticists have shown that some progeroid syndromes are caused by...	14th October, 2009	Department of Medicine, University of California, Los Angeles, California	Annu Rev Genomics Hum Genet. 2009;10:153-74. DOI Direct Link
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Farnesyltranstransferase Patents:
US Patent No.	Title
7291482	Mutations affecting plasmid copy number
6969595	Carotenoid production from a single carbon substrate
7064196	Genes encoding carotenoid compounds
7070952	Genes encoding carotenoid compounds
7173120	Regulatory sequences for regulation of gene expression in plants and other organisms, and compositions, products and methods related thereto
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