Farnesyltranstransferase

In enzymology, a farnesyltranstransferase is an enzyme that catalyzes the chemical reaction:trans,trans-farnesyl diphosphate + isopentenyl diphosphate $ightleftharpoons$ diphosphate + geranylgeranyl diphosphateThus, the two substrates of this enzyme are trans,trans-farnesyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and geranylgeranyl diphosphate.This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase. Other names in common use include geranylgeranyl-diphosphate synthase, geranylgeranyl pyrophosphate synthetase, geranylgeranyl-PP synthetase, farnesyltransferase, and geranylgeranyl pyrophosphate synthase. This enzyme participates in biosynthesis of steroids and terpenoid biosynthesis. (From the Wikpedia article Farnesyltranstransferase.)

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Recent Publications on Farnesyltranstransferase:
Current status of clinical trials for glioblastoma. Glioblastoma, the most highly aggressive and lethal form of brain cancer,...	11th June, 2008	Toucan Capital Corp,	Rev Recent Clin Trials. 2006 Sep;1(3):265-81.
Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs. Protein prenyl transferases have been a focus of anti-cancer drug...	10th June, 2008	Department of Medicinal Chemistry and Molecular Pharmacology, School of	Bioorg Med Chem Lett. 2008 Mar 15;18(6):1889-92. Epub 2008 Feb 12. DOI Direct Link
Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007. Glioblastoma, the most highly aggressive and lethal form of brain cancer,...	23rd May, 2008	Department of Pediatrics, Division of Medical Genetics, University of	Am J Med Genet A. 2008 May 1;146A(9):1205-17. DOI Direct Link
Characterization of a PRL protein tyrosine phosphatase from Plasmodium falciparum. Isoprenylated proteins have important functions in cell growth and...	23rd April, 2008	Department of Molecular Biology and Microbiology, University of Central	Mol Biochem Parasitol. 2008 Mar;158(1):1-10. Epub 2007 Nov 17. DOI Direct Link
Expression of signaling mediators downstream of EGF-receptor predict sensitivity to small molecule inhibitors directed against the EGF-receptor pathway. The EGF-receptor (EGFR) and downstream signaling molecules have emerged as...	17th April, 2008	Department I of Internal Medicine, Center of Integrated Oncology,	J Thorac Oncol. 2008 Feb;3(2):170-3. DOI Direct Link
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Farnesyltranstransferase Clinical Trials:
Tipifarnib Versus Best Supportive Care in the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML)	Myeloid Leukemia;   Acute Disease
Letrozole With or Without Tipifarnib in Treating Women With Locally Advanced, Locally Recurrent, or Metastatic Breast Cancer	Breast Cancer
Tipifarnib in Preventing Cancer in Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas	Neurofibromatosis Type 1 (nf1);   Precancerous/Nonmalignant Condition;   Sarcoma
BMS-214662 in Treating Patients With Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myeloid Leukemia	Leukemia;   Myelodysplastic Syndromes
Study of ZARNESTRA™ as Postconsolidation Therapy for Acute Myeloid Leukemia in Subjects 60 Years & Older	Acute Myeloid Leukemia
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Farnesyltranstransferase Patents:
US Patent No.	Title
7291482	Mutations affecting plasmid copy number
6969595	Carotenoid production from a single carbon substrate
7064196	Genes encoding carotenoid compounds
7070952	Genes encoding carotenoid compounds
7173120	Regulatory sequences for regulation of gene expression in plants and other organisms, and compositions, products and methods related thereto
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