Fasciculation

A fasciculation is a small, local, involuntary muscle contraction visible under the skin arising from the spontaneous discharge of a bundle of skeletal muscle fibers. Fasciculations have a variety of causes, the majority of which are benign, but can also be due to disease of the motor neurons. (From the Wikpedia article Fasciculation.)

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Recent Publications on Fasciculation:
Unilateral hypoglossal nerve palsy due to neurovascular conflict in a child. A neurovascular conflict (NC) consists of a pathological contact between a...	30th September, 2008	Department of Pediatrics, University of Padova, Via Giustiniani, 3, 35128	Brain Dev. 2008 Sep 24. DOI Direct Link
Development of Isaacs' syndrome following complete recovery of voltage-gated potassium channel antibody-associated limbic encephalitis. Autoantibodies against voltage-gated potassium channels (VGKC-Abs) are...	20th September, 2008	Department of Neurology, Graduate School of Medicine, Chiba University,	J Neurol Sci. 2008 Sep 16. DOI Direct Link
Loss of short dystrophin isoform Dp71 in olfactory ensheathing cells causes vomeronasal nerve defasciculation in mouse olfactory system. The Duchenne muscular dystrophy (DMD) gene encodes dystrophin, which is a...	16th September, 2008	Laboratory of Molecular Embryology, Department of Bioscience, Kitasato	Exp Neurol. 2008 Sep;213(1):36-47. Epub 2008 May 16. DOI Direct Link
A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation. We have investigated the role of N-methyl-d-aspartate receptors (NMDARs)...	16th September, 2008	Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences,	Exp Cell Res. 2008 Aug 15;314(14):2603-17. Epub 2008 Jun 14. DOI Direct Link
Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes. The cell adhesion molecule TAG-1 is expressed by neurons and glial cells...	2nd September, 2008	Department of Basic Science, University of Crete Medical School, and	Mol Cell Neurosci. 2008 Aug 9. DOI Direct Link
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Fasciculation Clinical Trials:
EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS)	Amyotrophic Lateral Sclerosis;   Cerebrospinal Fluid;   Neurodegenerative Disease;   Motor Neuron Disease

Fasciculation Patents:
US Patent No.	Title
7189529	PRO792 nucleic acids
7211602	Treatment of neurodegenerative disorders through the modulation of the polyamine pathway
7214656	PRO792 polypeptides
7220835	Secreted and transmembrane polypeptides and nucleic acids encoding the same
7226908	Use of VEGF and homologues to treat neuron disorders
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