Recent Publications on Fatty Acid Synthetase Complex: |  |
Site-specific incorporation of chemical probes into proteins for NMR.
The ability to incorporate chemical probes into peptides is of great...
Direct Link | 11th October, 2008
| Department of Chemistry, Massachusetts Institute of Technology, Cambridge,
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Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells.
PURPOSE: For many tumor cells, de novo lipogenesis is a requirement for...
Direct Link | 9th October, 2008
| Department of Cancer Biology and Therapeutics, Merck Research
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Inhibition of the fungal fatty acid synthase type I multienzyme complex.
Fatty acids are among the major building blocks of living cells, making...
Direct Link | 7th October, 2008
| Department of Membrane Biochemistry, Max Planck Institute of Biochemistry,
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Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance.
Insulin resistance is a characteristic feature of type 2 diabetes and...
Direct Link | 7th October, 2008
| Division of Diabetes, Univ. of Texas Health Science Center, San Antonio,
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Dietary polyunsaturated fatty acids (C18:2 omega6 and C18:3 omega3) do not suppress hepatic lipogenesis.
Omega 3 polyunsaturated fatty acids are promoted as beneficial in the...
Direct Link | 4th October, 2008
| Center for Metabolic Disease, Ordway Research Institute, Albany Medical
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A novel paradigm of fatty acid beta-oxidation exemplified by the thioesterase-dependent partial degradation of conjugated linoleic acid that fully supports growth of Escherichia coli.
An alternative pathway of beta-oxidation for unsaturated fatty acids was...
Direct Link | 26th September, 2008
| Department of Chemistry, City College and Graduate School of the City
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Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma.
PURPOSE: Fatty acid synthase is a key enzyme in the de novo biosynthesis...
Direct Link | 19th September, 2008
| Department of Urology, National Defense Medical College, Tokorozawa-City,
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Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.
The identification of potential new anti-tubercular chemotherapeutics is...
Direct Link | 18th September, 2008
| University of Birmingham, School of Biosciences, Edgbaston, Birmingham B15
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| Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase.
| 16th September, 2008
| The Urological Diseases Research Center and Department of Surgery,
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Novel intermolecular iterative mechanism for biosynthesis of mycoketide catalyzed by a bimodular polyketide synthase.
In recent years, remarkable versatility of polyketide synthases (PKSs) has...
Direct Link | 11th September, 2008
| National Institute of Immunology, New Delhi, India.
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The crystal structure of a mammalian fatty acid synthase.
Mammalian fatty acid synthase is a large multienzyme that catalyzes all...
Direct Link | 10th September, 2008
| Institute of Molecular Biology and Biophysics, ETH Zurich, 8092 Zurich,
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Biochemistry. An enzyme assembly line.
Mammalian fatty acid synthase is a large multienzyme that catalyzes all...
Direct Link | 10th September, 2008
| Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
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Structural basis for the selectivity of the external thioesterase of the surfactin synthetase.
Non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS)...
Direct Link | 4th September, 2008
| Institute of Biophysical Chemistry and Center for Biomolecular Magnetic
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In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy.
In vivo incorporation of isotopically labeled unnatural amino acids into...
Direct Link | 3rd September, 2008
| Genomics Institute of the Novartis Research Foundation, 10675 John Jay
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Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells.
PURPOSE: Fatty acid synthase has been shown to be over expressed in a wide...
Direct Link | 3rd September, 2008
| Department of Urology, National Defense Medical College, Tokorozawa-City,
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