Floxuridine

Floxuridine is an oncology drug that belongs to the class known as antimetabolites. The drug is most often used in the treatment of colorectal cancer. (From the Wikpedia article Floxuridine.)

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Recent Publications on Floxuridine:
Regional chemotherapy for unresectable primary liver cancer: results of a phase II clinical trial and assessment of DCE-MRI as a biomarker of survival. BACKGROUND: This study reports the results of hepatic arterial infusion...	10th November, 2009	Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York,	Ann Oncol. 2009 Sep;20(9):1589-95. Epub 2009 Jun 2. DOI Direct Link
Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Peroxisome proliferator-activated receptor gamma coactivator-1alpha...	5th November, 2009	National Laboratory of Medical Molecular Biology, Institute of Basic	Mol Pharmacol. 2009 Oct;76(4):854-60. Epub 2009 Jul 14. DOI Direct Link
Hepatic arterial infusion for unresectable colorectal liver metastases combined or not with systemic chemotherapy. BACKGROUND: The hypothesis was tested that systemic chemotherapy might...	23rd October, 2009	Clinica Chirurgica II, Department of Oncological and Surgical Sciences,	Anticancer Res. 2009 Oct;29(10):4139-44.
Substrate specificity of lipase from Burkholderia cepacia in the synthesis of 3'-arylaliphatic acid esters of floxuridine. Among the five vinyl esters bearing phenyl ring in acyl moiety, the lipase...	16th October, 2009	State Key Laboratory of Pulp and Paper Engineering, South China University	J Biotechnol. 2009 Jul 15;142(3-4):267-70. Epub 2009 Jun 17. DOI Direct Link
Selective internal radiation therapy for liver metastases from colorectal cancer. BACKGROUND: Liver metastases are often the dominant site of metastatic...	13th October, 2009	The Queen Elizabeth Hospital, 28 Woodville Road,, Woodville, SA,	Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007045. DOI Direct Link
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Press Releases About Floxuridine:
Celator(R) Pharmaceuticals Presents New Data on CPX-351 And CPX-1 at the American Association for Cancer Research	22nd April, 2009	Celator Pharmaceuticals	PRINCETON, N.J., April 22 /PRNewswire/ -- Celator Pharmaceuticals today announced that new data from animal studies of CPX-351 (Cytarabine:Daunorubicin) Liposome Injection in consolidation treatment

Floxuridine Patents:
US Patent No.	Title
7589125	2,4-dihydroxybenzoic acid derivatives
7598043	Use of vascular endothelial growth factor receptor 1+ cells in treating and monitoring cancer and in screening for chemotherapeutics
7598052	Expression profile of thyroid cancer
7598261	Spirocyclic heterocyclic derivatives and methods of their use
7598348	Adiponectin receptor variant, AdipoR2v2
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