Galactosylceramidase

Galactosylceramidase is an enzyme which removes galactose from ceramide derivatives . (From the Wikpedia article Galactosylceramidase.)

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Recent Publications on Galactosylceramidase:
Clinical and immunopathologic alterations in rhesus macaques affected with globoid cell leukodystrophy. Globoid cell leukodystrophy, or Krabbe's disease, is a severe disorder of...	3rd April, 2008	DVM, PhD, Division of Comparative Pathology, Tulane National Primate	Am J Pathol. 2008 Jan;172(1):98-111. Epub 2007 Dec 28. DOI Direct Link
Central nervous system-directed AAV2/5-mediated gene therapy synergizes with bone marrow transplantation in the murine model of globoid-cell leukodystrophy. Globoid-cell leukodystrophy (GLD) is a rapidly progressing inherited...	1st April, 2008	Department of Internal Medicine, Washington University School of Medicine,	Mol Ther. 2007 Jan;15(1):44-52. DOI Direct Link
Cellular uptake and lysosomal delivery of galactocerebrosidase tagged with the HIV Tat protein transduction domain. A number of studies have shown that a short peptide, the protein...	15th February, 2008	Department of Medicine, Louisiana State University Health Sciences Center,	J Neurochem. 2008 Feb;104(4):1055-64. Epub 2007 Nov 6. DOI Direct Link
Autonomic denervation of lymphoid organs leads to epigenetic immune atrophy in a mouse model of Krabbe disease. Lysosomal beta-galactosylceramidase deficiency results in demyelination...	23rd January, 2008	Department of Anatomy, College of Medicine, University of Illinois at	J Neurosci. 2007 Dec 12;27(50):13730-8. DOI Direct Link
Peripheral neuropathy in the twitcher mouse: accumulation of extracellular matrix in the endoneurium and aberrant expression of ion channels. Globoid cell leukodystrophy (GLD; Krabbe's disease), caused by a genetic...	4th January, 2008	Department of Pathology and Laboratory Medicine, University of North	Acta Neuropathol. 2008 May;115(5):577-87. Epub 2008 Jan 3. DOI Direct Link
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Galactosylceramidase Patents:
US Patent No.	Title
5716614	Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-conjugated polycationic carrier
6566099	Nucleic acid encoding a chimeric polypeptide
6670194	Rapid quantitative analysis of proteins or protein function in complex mixtures
6706867	DNA array sequence selection
6730297	Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders
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