Genetics

, the molecular basis for inheritance. Each strand of DNA is a chain of nucleotides, matching each other in the center to form what look like rungs on a twisted ladder.Genetics is the science of heredity and variation in living organisms. Knowledge of the inheritance of characteristics has been implicitly used since prehistoric times for improving crop plants and animals through selective breeding. However, the modern science of genetics, which seeks to understand the mechanisms of inheritance, only began with the work of Gregor Mendel in the mid-1800s. Although he did not know the physical basis for heredity, Mendel observed that inheritance is fundamentally a discrete process with specific traits that are inherited in an independent manner — these basic units of inheritance are now called genes.Following the rediscovery of Mendel's observations in the early 1900s, research in 1910s yielded the first physical understanding of inheritance — that genes are arranged linearly along large cellular structures called chromosomes. By the 1950s it was understood that the core of a chromosome was a long molecule called DNA and genes existed as linear sections within the molecule. A single strand of DNA is a chain of four types of nucleotides; hereditary information is contained within the sequence of these nucleotides. Solved by Watson, Wilkins, and Crick in 1953, DNA's three-dimensional structure is a double-stranded helix, with the nucleotides on each strand physically matched to each other. Each strand acts as a template for synthesis of a new partner strand, providing the physical mechanism for the inheritance of information.The sequence of nucleotides in DNA is used to produce specific sequences of amino acids, creating proteins — a correspondence known as the "genetic code". This sequence of amino acids in a protein determines how it folds into a three-dimensional structure, this structure is in turn responsible for the protein's function. Proteins are responsible for almost all functional roles in the cell. A change to DNA sequence can change a protein's structure and behavior, and this can have dramatic consequences in the cell and on the organism as a whole.Although genetics plays a large role in determining the appearance and behavior of organisms, it is the interaction of genetics with the environment an organism experiences that determines the ultimate outcome. For example, while genes play a role in determining a person's height, the nutrition and health that person experiences in childhood also have a large effect. (From the Wikpedia article Genetics.)

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Recent Publications on Genetics:
Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines. In defining the genetic profiles in cancer, cytogenetically aberrant cell...	21st November, 2009	Section of Cancer Genomics, Genetics Branch, Center for Cancer Research,	Genes Chromosomes Cancer. 2009 Nov 19. DOI Direct Link
AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia. We report a case of childhood acute lymphoblastic leukemia (ALL) with both...	21st November, 2009	Medical Genetics Department, Medical Faculty, Uludag University, Bursa,	J Clin Lab Anal. 2009 Nov 19;23(6):368-371. DOI Direct Link
General lessons from large-scale studies to identify human cancer predisposition genes. There are now about 100 genes known to cause Mendelian inherited cancer...	21st November, 2009	Molecular and Population Genetics Laboratory, Wellcome Trust Centre for	J Pathol. 2009 Nov 19. DOI Direct Link
A systematic association mapping on chromosome 6q in bipolar affective disorder-evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder. Strong evidence of linkage between chromosomal region 6q16-q22 and bipolar...	21st November, 2009	Institute of Human Genetics, University of Bonn, Bonn, Germany.	Am J Med Genet B Neuropsychiatr Genet. 2009 Nov 19. DOI Direct Link
Regulation of aging by unc-13 and sbt-1 in Caenorhabditis elegans is temperature-dependent. Objective To investigate the role of environmental factor - temperature in...	21st November, 2009	Key Laboratory of Developmental Genes and Human Disease in Ministry of	Neurosci Bull. 2009 Dec;25(6):335-342.
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Press Releases About Genetics:
deCODE Receives Delisting Notice From Nasdaq, Plans to Appeal	24th November, 2009	deCODE Genetics Inc	REYKJAVIK, Iceland, November 24 /PRNewswire-FirstCall/ -- deCODE genetics, Inc. (Nasdaq:DCGN) today announced that it has received notice from the Nasdaq Stock Market that trading in the company
deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court	24th November, 2009	DeCODE Genetics Inc	REYKJAVIK, Iceland, November 24 /PRNewswire-FirstCall/ -- deCODE genetics, Inc. (Nasdaq:DCGN) today announced the approval of all of its "first day" motions by the U.S. Bankruptcy Court
5AM Solutions Launches Family Helix Community	24th November, 2009	5AM Solutions	RESTON, Va., Nov. 24 /PRNewswire/ -- Today, 5AM Solutions announced the launch of the Family Helix Community, an interactive web-based portal designed to facilitate collaboration and communication
Richard T. Crowder Joins Neogen's Board of Directors	23rd November, 2009	Neogen Corporation	LANSING, Mich., Nov. 23 /PRNewswire-FirstCall/ -- Neogen Corporation (Nasdaq: NEOG) announced today that Richard T. Crowder, Ph.D., was elected to Neogen's Board of Directors at the company&apos
Knome Launches First Platform-Agnostic Human Genome Sequencing and Analysis Service for Researchers	18th November, 2009	Knome, Inc.	-- Clinically trained researchers with extensive expertise in specific diseases, for whom mass sequencing approaches are novel and unfamiliar tools - Knome's expertise in

BioNews Results for Genetics:
Tremor Genetics: New tremor genetics study results from La Trobe University described	NewsRX:  Nov 21 2009 5:48AM Matching: genetics
Life Sciences: Research from University of Oxford, Wellcome Trust Center for Human Genetics yields new findings on life sciences	NewsRX:  Nov 21 2009 5:48AM Matching: genetics
Researchers identify role of gene in tumor development, growth and progression	PhysOrg.com:  Nov 21 2009 3:50AM Matching: genetics
Senior Statistical Genetics in High-throughput Sequencing Analysis	Nature:  Nov 20 2009 2:08AM Matching: genetics
Campylobacter: Research from University of Leicester, Department of Genetics has provided new data on campylobacter	NewsRX:  Nov 20 2009 2:14PM Matching: genetics
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Genetics Patents:
US Patent No.	Title
7618808	Remote control video incubation and reaction chamber
7619001	Utilization of dialkylfumarates
7619061	Antigen constructs useful in the detection and differentiation of antibodies to HIV
7619062	PRO214 polypeptides
7619064	Bacillus thuringiensis gene with coleopteran activity
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Companies working in the area of Genetics from Bioportfolio's Biocorporate database :
Company Name
Avalon Pharmaceuticals Avalon Pharmaceuticals' primary mission is to discover and develop innovative small molecule therapeutics using cutting-edge genomic technologies. Through its comprehensive genomics approach, Avalon... www.avalonrx.com/        View full profile
BioRobotics Limited BioRobotics was founded as a privately funded venture with the aim of providing quality solutions to automation and robotics in the field of molecular biology. The BioPick, the company’s first product... www.biorobotics.co.uk/        View full profile
Clingenix Incorporated Clingenix, Inc. was founded in 1998 by leading scientists from Harvard, Stanford, and private industry to provide pharmacogenomic as well as conventional research, development and application services... www.clingenix.com/        View full profile
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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org